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Night‐Time Apomorphine Infusion: Who Are the Best Candidates?

BACKGROUND: We recently demonstrated in a randomized controlled trial (APOMORPHEE, NCT02940912) that night‐time only subcutaneous apomorphine infusion improves sleep disturbances and insomnia in patients with advanced Parkinson's disease and moderate to severe insomnia. OBJECTIVES: To identify...

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Autores principales: Cochen De Cock, Valérie, Dodet, Pauline, Leu‐Semenescu, Smaranda, Aerts, Cécile, Abril, Beatriz, Castelnovo, Giovanni, Landragin, Nicolas, Drapier, Sophie, Olivet, Hélène, Corbillé, Anne‐Gaëlle, Leclair‐Visonneau, Laurène, Anheim, Mathieu, Vidailhet, Marie, Arnulf, Isabelle, Doulazmi, Mohamed, Roze, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450238/
https://www.ncbi.nlm.nih.gov/pubmed/37635769
http://dx.doi.org/10.1002/mdc3.13799
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author Cochen De Cock, Valérie
Dodet, Pauline
Leu‐Semenescu, Smaranda
Aerts, Cécile
Abril, Beatriz
Castelnovo, Giovanni
Landragin, Nicolas
Drapier, Sophie
Olivet, Hélène
Corbillé, Anne‐Gaëlle
Leclair‐Visonneau, Laurène
Anheim, Mathieu
Vidailhet, Marie
Arnulf, Isabelle
Doulazmi, Mohamed
Roze, Emmanuel
author_facet Cochen De Cock, Valérie
Dodet, Pauline
Leu‐Semenescu, Smaranda
Aerts, Cécile
Abril, Beatriz
Castelnovo, Giovanni
Landragin, Nicolas
Drapier, Sophie
Olivet, Hélène
Corbillé, Anne‐Gaëlle
Leclair‐Visonneau, Laurène
Anheim, Mathieu
Vidailhet, Marie
Arnulf, Isabelle
Doulazmi, Mohamed
Roze, Emmanuel
author_sort Cochen De Cock, Valérie
collection PubMed
description BACKGROUND: We recently demonstrated in a randomized controlled trial (APOMORPHEE, NCT02940912) that night‐time only subcutaneous apomorphine infusion improves sleep disturbances and insomnia in patients with advanced Parkinson's disease and moderate to severe insomnia. OBJECTIVES: To identify the best candidates for receiving night‐time only subcutaneous apomorphine infusion in routine care. METHODS: In this post‐hoc analysis of APOMORPHEE, we compared the characteristics of patients according to whether they chose to continue night‐time only subcutaneous apomorphine infusion at the end of the study period or not. RESULTS: Half of the patients (22/42) chose to continue the treatment. Off duration (day or night), painful Off dystonia, and insomnia severity at baseline were associated with night‐time only apomorphine continuation. Multivariate analysis retained only Off duration as an independent predictor of continuation. CONCLUSIONS: The best candidates for night‐time only apomorphine are patients with severe and prolonged Off periods (day or night) and severe insomnia.
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spelling pubmed-104502382023-08-26 Night‐Time Apomorphine Infusion: Who Are the Best Candidates? Cochen De Cock, Valérie Dodet, Pauline Leu‐Semenescu, Smaranda Aerts, Cécile Abril, Beatriz Castelnovo, Giovanni Landragin, Nicolas Drapier, Sophie Olivet, Hélène Corbillé, Anne‐Gaëlle Leclair‐Visonneau, Laurène Anheim, Mathieu Vidailhet, Marie Arnulf, Isabelle Doulazmi, Mohamed Roze, Emmanuel Mov Disord Clin Pract Brief Reports BACKGROUND: We recently demonstrated in a randomized controlled trial (APOMORPHEE, NCT02940912) that night‐time only subcutaneous apomorphine infusion improves sleep disturbances and insomnia in patients with advanced Parkinson's disease and moderate to severe insomnia. OBJECTIVES: To identify the best candidates for receiving night‐time only subcutaneous apomorphine infusion in routine care. METHODS: In this post‐hoc analysis of APOMORPHEE, we compared the characteristics of patients according to whether they chose to continue night‐time only subcutaneous apomorphine infusion at the end of the study period or not. RESULTS: Half of the patients (22/42) chose to continue the treatment. Off duration (day or night), painful Off dystonia, and insomnia severity at baseline were associated with night‐time only apomorphine continuation. Multivariate analysis retained only Off duration as an independent predictor of continuation. CONCLUSIONS: The best candidates for night‐time only apomorphine are patients with severe and prolonged Off periods (day or night) and severe insomnia. John Wiley & Sons, Inc. 2023-06-13 /pmc/articles/PMC10450238/ /pubmed/37635769 http://dx.doi.org/10.1002/mdc3.13799 Text en © 2023 The Authors. Movement Disorders Clinical Practice published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Reports
Cochen De Cock, Valérie
Dodet, Pauline
Leu‐Semenescu, Smaranda
Aerts, Cécile
Abril, Beatriz
Castelnovo, Giovanni
Landragin, Nicolas
Drapier, Sophie
Olivet, Hélène
Corbillé, Anne‐Gaëlle
Leclair‐Visonneau, Laurène
Anheim, Mathieu
Vidailhet, Marie
Arnulf, Isabelle
Doulazmi, Mohamed
Roze, Emmanuel
Night‐Time Apomorphine Infusion: Who Are the Best Candidates?
title Night‐Time Apomorphine Infusion: Who Are the Best Candidates?
title_full Night‐Time Apomorphine Infusion: Who Are the Best Candidates?
title_fullStr Night‐Time Apomorphine Infusion: Who Are the Best Candidates?
title_full_unstemmed Night‐Time Apomorphine Infusion: Who Are the Best Candidates?
title_short Night‐Time Apomorphine Infusion: Who Are the Best Candidates?
title_sort night‐time apomorphine infusion: who are the best candidates?
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450238/
https://www.ncbi.nlm.nih.gov/pubmed/37635769
http://dx.doi.org/10.1002/mdc3.13799
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