Cargando…

Animal model for tendinopathy

BACKGROUND: Tendinopathy is a common motor system disease that leads to pain and reduced function. Despite its prevalence, our mechanistic understanding is incomplete, leading to limited efficacy of treatment options. Animal models contribute significantly to our understanding of tendinopathy and so...

Descripción completa

Detalles Bibliográficos
Autores principales: Luo, Junchao, Wang, Zetao, Tang, Chenqi, Yin, Zi, Huang, Jiayun, Ruan, Dengfeng, Fei, Yang, Wang, Canlong, Mo, Xianan, Li, Jiajin, Zhang, Jun, Fang, Cailian, Li, Jianyou, Chen, Xiao, Shen, Weiliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Speaking Orthopaedic Society 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450357/
https://www.ncbi.nlm.nih.gov/pubmed/37637777
http://dx.doi.org/10.1016/j.jot.2023.06.005
_version_ 1785095180222726144
author Luo, Junchao
Wang, Zetao
Tang, Chenqi
Yin, Zi
Huang, Jiayun
Ruan, Dengfeng
Fei, Yang
Wang, Canlong
Mo, Xianan
Li, Jiajin
Zhang, Jun
Fang, Cailian
Li, Jianyou
Chen, Xiao
Shen, Weiliang
author_facet Luo, Junchao
Wang, Zetao
Tang, Chenqi
Yin, Zi
Huang, Jiayun
Ruan, Dengfeng
Fei, Yang
Wang, Canlong
Mo, Xianan
Li, Jiajin
Zhang, Jun
Fang, Cailian
Li, Jianyou
Chen, Xiao
Shen, Weiliang
author_sort Luo, Junchao
collection PubMed
description BACKGROUND: Tendinopathy is a common motor system disease that leads to pain and reduced function. Despite its prevalence, our mechanistic understanding is incomplete, leading to limited efficacy of treatment options. Animal models contribute significantly to our understanding of tendinopathy and some therapeutic options. However, the inadequacies of animal models are also evident, largely due to differences in anatomical structure and the complexity of human tendinopathy. Different animal models reproduce different aspects of human tendinopathy and are therefore suitable for different scenarios. This review aims to summarize the existing animal models of tendinopathy and to determine the situations in which each model is appropriate for use, including exploring disease mechanisms and evaluating therapeutic effects. METHODS: We reviewed relevant literature in the PubMed database from January 2000 to December 2022 using the specific terms ((tendinopathy) OR (tendinitis)) AND (model) AND ((mice) OR (rat) OR (rabbit) OR (lapin) OR (dog) OR (canine) OR (sheep) OR (goat) OR (horse) OR (equine) OR (pig) OR (swine) OR (primate)). This review summarized different methods for establishing animal models of tendinopathy and classified them according to the pathogenesis they simulate. We then discussed the advantages and disadvantages of each model, and based on this, identified the situations in which each model was suitable for application. RESULTS: For studies that aim to study the pathophysiology of tendinopathy, naturally occurring models, treadmill models, subacromial impingement models and metabolic models are ideal. They are closest to the natural process of tendinopathy in humans. For studies that aim to evaluate the efficacy of possible treatments, the selection should be made according to the pathogenesis simulated by the modeling method. Existing tendinopathy models can be classified into six types according to the pathogenesis they simulate: extracellular matrix synthesis-decomposition imbalance, inflammation, oxidative stress, metabolic disorder, traumatism and mechanical load. CONCLUSIONS: The critical factor affecting the translational value of research results is whether the selected model is matched with the research purpose. There is no single optimal model for inducing tendinopathy, and researchers must select the model that is most appropriate for the study they are conducting. THE TRANSLATIONAL POTENTIAL OF THIS ARTICLE: The critical factor affecting the translational value of research results is whether the animal model used is compatible with the research purpose. This paper provides a rationale and practical guide for the establishment and selection of animal models of tendinopathy, which is helpful to improve the clinical transformation ability of existing models and develop new models.
format Online
Article
Text
id pubmed-10450357
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Chinese Speaking Orthopaedic Society
record_format MEDLINE/PubMed
spelling pubmed-104503572023-08-26 Animal model for tendinopathy Luo, Junchao Wang, Zetao Tang, Chenqi Yin, Zi Huang, Jiayun Ruan, Dengfeng Fei, Yang Wang, Canlong Mo, Xianan Li, Jiajin Zhang, Jun Fang, Cailian Li, Jianyou Chen, Xiao Shen, Weiliang J Orthop Translat Review Article BACKGROUND: Tendinopathy is a common motor system disease that leads to pain and reduced function. Despite its prevalence, our mechanistic understanding is incomplete, leading to limited efficacy of treatment options. Animal models contribute significantly to our understanding of tendinopathy and some therapeutic options. However, the inadequacies of animal models are also evident, largely due to differences in anatomical structure and the complexity of human tendinopathy. Different animal models reproduce different aspects of human tendinopathy and are therefore suitable for different scenarios. This review aims to summarize the existing animal models of tendinopathy and to determine the situations in which each model is appropriate for use, including exploring disease mechanisms and evaluating therapeutic effects. METHODS: We reviewed relevant literature in the PubMed database from January 2000 to December 2022 using the specific terms ((tendinopathy) OR (tendinitis)) AND (model) AND ((mice) OR (rat) OR (rabbit) OR (lapin) OR (dog) OR (canine) OR (sheep) OR (goat) OR (horse) OR (equine) OR (pig) OR (swine) OR (primate)). This review summarized different methods for establishing animal models of tendinopathy and classified them according to the pathogenesis they simulate. We then discussed the advantages and disadvantages of each model, and based on this, identified the situations in which each model was suitable for application. RESULTS: For studies that aim to study the pathophysiology of tendinopathy, naturally occurring models, treadmill models, subacromial impingement models and metabolic models are ideal. They are closest to the natural process of tendinopathy in humans. For studies that aim to evaluate the efficacy of possible treatments, the selection should be made according to the pathogenesis simulated by the modeling method. Existing tendinopathy models can be classified into six types according to the pathogenesis they simulate: extracellular matrix synthesis-decomposition imbalance, inflammation, oxidative stress, metabolic disorder, traumatism and mechanical load. CONCLUSIONS: The critical factor affecting the translational value of research results is whether the selected model is matched with the research purpose. There is no single optimal model for inducing tendinopathy, and researchers must select the model that is most appropriate for the study they are conducting. THE TRANSLATIONAL POTENTIAL OF THIS ARTICLE: The critical factor affecting the translational value of research results is whether the animal model used is compatible with the research purpose. This paper provides a rationale and practical guide for the establishment and selection of animal models of tendinopathy, which is helpful to improve the clinical transformation ability of existing models and develop new models. Chinese Speaking Orthopaedic Society 2023-08-14 /pmc/articles/PMC10450357/ /pubmed/37637777 http://dx.doi.org/10.1016/j.jot.2023.06.005 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Luo, Junchao
Wang, Zetao
Tang, Chenqi
Yin, Zi
Huang, Jiayun
Ruan, Dengfeng
Fei, Yang
Wang, Canlong
Mo, Xianan
Li, Jiajin
Zhang, Jun
Fang, Cailian
Li, Jianyou
Chen, Xiao
Shen, Weiliang
Animal model for tendinopathy
title Animal model for tendinopathy
title_full Animal model for tendinopathy
title_fullStr Animal model for tendinopathy
title_full_unstemmed Animal model for tendinopathy
title_short Animal model for tendinopathy
title_sort animal model for tendinopathy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450357/
https://www.ncbi.nlm.nih.gov/pubmed/37637777
http://dx.doi.org/10.1016/j.jot.2023.06.005
work_keys_str_mv AT luojunchao animalmodelfortendinopathy
AT wangzetao animalmodelfortendinopathy
AT tangchenqi animalmodelfortendinopathy
AT yinzi animalmodelfortendinopathy
AT huangjiayun animalmodelfortendinopathy
AT ruandengfeng animalmodelfortendinopathy
AT feiyang animalmodelfortendinopathy
AT wangcanlong animalmodelfortendinopathy
AT moxianan animalmodelfortendinopathy
AT lijiajin animalmodelfortendinopathy
AT zhangjun animalmodelfortendinopathy
AT fangcailian animalmodelfortendinopathy
AT lijianyou animalmodelfortendinopathy
AT chenxiao animalmodelfortendinopathy
AT shenweiliang animalmodelfortendinopathy