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Evaluation of childhood developing via optical coherence tomography-angiography in Qamdo, Tibet, China: A prospective cross-sectional, school-based study

BACKGROUND: Optical coherence tomography angiography (OCTA) is a new and reliable machine used to evaluate retinal structure and macular perfusion in children. The use of OCTA under bad condition such as high altitude, low atmospheric oxygen, and low humidity, in children is rarely. AIM: To quantify...

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Autores principales: Sun, Ke-Xin, Xiang, Yong-Guo, Zhang, Tong, Yi, Sheng-Lan, Xia, Jiu-Yi, Yang, Xin, Zheng, Shi-Jie, Ji, Yan, Wan, Wen-Juan, Hu, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450379/
https://www.ncbi.nlm.nih.gov/pubmed/37637695
http://dx.doi.org/10.12998/wjcc.v11.i23.5479
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author Sun, Ke-Xin
Xiang, Yong-Guo
Zhang, Tong
Yi, Sheng-Lan
Xia, Jiu-Yi
Yang, Xin
Zheng, Shi-Jie
Ji, Yan
Wan, Wen-Juan
Hu, Ke
author_facet Sun, Ke-Xin
Xiang, Yong-Guo
Zhang, Tong
Yi, Sheng-Lan
Xia, Jiu-Yi
Yang, Xin
Zheng, Shi-Jie
Ji, Yan
Wan, Wen-Juan
Hu, Ke
author_sort Sun, Ke-Xin
collection PubMed
description BACKGROUND: Optical coherence tomography angiography (OCTA) is a new and reliable machine used to evaluate retinal structure and macular perfusion in children. The use of OCTA under bad condition such as high altitude, low atmospheric oxygen, and low humidity, in children is rarely. AIM: To quantify the macular micro-vasculature in healthy children of various ages using OCTA in Qamdo. METHODS: Design: Prospective cross-sectional, school-based study. Three hundred and forty-seven normal students from 9 schools in 4 different areas in Qamdo were included. OCTA was performed on a 3 mm × 3 mm area centered on the macular region and macular cube 512 × 128 showed details in macular. Early treatment of diabetic retinopathy study Vessel Flow Density (VD) of the macular central vascular plexus density (CVD), inner vascular plexus density (IVD), full vascular plexus density (FVD), and the size of the foveal avascular zone (FAZ) were measured. All these results corrected by t/s = 3.382 × 0.01306 × (axial length-1.82). The differences were compared among various ages, sexes and living environments. RESULTS: The mean FAZ area in all eyes was 0.27 mm(2) ± 0.12 mm(2). The mean foveal thickness (MFT) in the macular cube was 227.64 μm ± 23.51 μm. Compared with girls, boys had a lager FAZ (P = 0.0029). Among the different age groups, MFT (P < 0.001) and FVD (P < 0.0001), IVD (P < 0.0001), and CVD (P = 0.0050) increased with age. FAZ areas were not correlated with age (P = 0.8853) or others (MFT, area). CONCLUSION: OCTA can use to evaluate macular perfusion in children. Our data bridge the gap between structural OCT and perfusion density in children in high altitude. Even though these were not a longitudinal study, it may provide us with hints about retina development during puberty and clinical implications of OCTA in children.
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spelling pubmed-104503792023-08-26 Evaluation of childhood developing via optical coherence tomography-angiography in Qamdo, Tibet, China: A prospective cross-sectional, school-based study Sun, Ke-Xin Xiang, Yong-Guo Zhang, Tong Yi, Sheng-Lan Xia, Jiu-Yi Yang, Xin Zheng, Shi-Jie Ji, Yan Wan, Wen-Juan Hu, Ke World J Clin Cases Prospective Study BACKGROUND: Optical coherence tomography angiography (OCTA) is a new and reliable machine used to evaluate retinal structure and macular perfusion in children. The use of OCTA under bad condition such as high altitude, low atmospheric oxygen, and low humidity, in children is rarely. AIM: To quantify the macular micro-vasculature in healthy children of various ages using OCTA in Qamdo. METHODS: Design: Prospective cross-sectional, school-based study. Three hundred and forty-seven normal students from 9 schools in 4 different areas in Qamdo were included. OCTA was performed on a 3 mm × 3 mm area centered on the macular region and macular cube 512 × 128 showed details in macular. Early treatment of diabetic retinopathy study Vessel Flow Density (VD) of the macular central vascular plexus density (CVD), inner vascular plexus density (IVD), full vascular plexus density (FVD), and the size of the foveal avascular zone (FAZ) were measured. All these results corrected by t/s = 3.382 × 0.01306 × (axial length-1.82). The differences were compared among various ages, sexes and living environments. RESULTS: The mean FAZ area in all eyes was 0.27 mm(2) ± 0.12 mm(2). The mean foveal thickness (MFT) in the macular cube was 227.64 μm ± 23.51 μm. Compared with girls, boys had a lager FAZ (P = 0.0029). Among the different age groups, MFT (P < 0.001) and FVD (P < 0.0001), IVD (P < 0.0001), and CVD (P = 0.0050) increased with age. FAZ areas were not correlated with age (P = 0.8853) or others (MFT, area). CONCLUSION: OCTA can use to evaluate macular perfusion in children. Our data bridge the gap between structural OCT and perfusion density in children in high altitude. Even though these were not a longitudinal study, it may provide us with hints about retina development during puberty and clinical implications of OCTA in children. Baishideng Publishing Group Inc 2023-08-16 2023-08-16 /pmc/articles/PMC10450379/ /pubmed/37637695 http://dx.doi.org/10.12998/wjcc.v11.i23.5479 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Prospective Study
Sun, Ke-Xin
Xiang, Yong-Guo
Zhang, Tong
Yi, Sheng-Lan
Xia, Jiu-Yi
Yang, Xin
Zheng, Shi-Jie
Ji, Yan
Wan, Wen-Juan
Hu, Ke
Evaluation of childhood developing via optical coherence tomography-angiography in Qamdo, Tibet, China: A prospective cross-sectional, school-based study
title Evaluation of childhood developing via optical coherence tomography-angiography in Qamdo, Tibet, China: A prospective cross-sectional, school-based study
title_full Evaluation of childhood developing via optical coherence tomography-angiography in Qamdo, Tibet, China: A prospective cross-sectional, school-based study
title_fullStr Evaluation of childhood developing via optical coherence tomography-angiography in Qamdo, Tibet, China: A prospective cross-sectional, school-based study
title_full_unstemmed Evaluation of childhood developing via optical coherence tomography-angiography in Qamdo, Tibet, China: A prospective cross-sectional, school-based study
title_short Evaluation of childhood developing via optical coherence tomography-angiography in Qamdo, Tibet, China: A prospective cross-sectional, school-based study
title_sort evaluation of childhood developing via optical coherence tomography-angiography in qamdo, tibet, china: a prospective cross-sectional, school-based study
topic Prospective Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450379/
https://www.ncbi.nlm.nih.gov/pubmed/37637695
http://dx.doi.org/10.12998/wjcc.v11.i23.5479
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