Gene signature reveals decreased SOX10-dependent transcripts in malignant cells from immune checkpoint inhibitor-resistant cutaneous melanomas

Evidence is mounting for cross-resistance between immune checkpoint and targeted kinase inhibitor therapies in cutaneous melanoma patients. Since the loss of the transcription factor, SOX10, causes tolerance to MAPK pathway inhibitors, we used bioinformatic techniques to determine if reduced SOX10 e...

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Detalles Bibliográficos
Autores principales: Purwin, Timothy J., Caksa, Signe, Sacan, Ahmet, Capparelli, Claudia, Aplin, Andrew E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450419/
https://www.ncbi.nlm.nih.gov/pubmed/37636077
http://dx.doi.org/10.1016/j.isci.2023.107472

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