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Phosphate-induced activation of VEGFR2 leads to caspase-9-mediated apoptosis of hypertrophic chondrocytes

Low circulating phosphate (Pi) leads to rickets, characterized by expansion of the hypertrophic chondrocytes (HCs) in the growth plate due to impaired HC apoptosis. Studies in HCs demonstrate that Pi activates the Raf/MEK/ERK1/2 and mitochondrial apoptotic pathways. To determine how Pi activates the...

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Detalles Bibliográficos
Autores principales:	Yadav, Prem Swaroop, Papaioannou, Garyfallia, Kobelski, Margaret M., Demay, Marie B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450517/ https://www.ncbi.nlm.nih.gov/pubmed/37636062 http://dx.doi.org/10.1016/j.isci.2023.107548

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