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The peroxidation-derived DNA adduct, 6-oxo-M(1)dG, is a strong block to replication by human DNA polymerase η

The DNA adduct 6-oxo-M(1)dG, (3-(2′-deoxy-β-D-erythro-pentofuranosyl)-6-oxo-pyrimido(1,2alpha)purin-10(3H)-one) is formed in the genome via oxidation of the peroxidation-derived adduct M(1)dG. However, the effect of 6-oxo-M(1)dG adducts on subsequent DNA replication is unclear. Here we investigated...

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Detalles Bibliográficos
Autores principales:	Richie-Jannetta, Robyn, Pallan, Pradeep, Kingsley, Philip J., Kamdar, Nikhil, Egli, Martin, Marnett, Lawrence J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450521/ https://www.ncbi.nlm.nih.gov/pubmed/37468099 http://dx.doi.org/10.1016/j.jbc.2023.105067

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