Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer

Clonal hematopoiesis (CH) is defined as clonal expansion of mutant hematopoietic stem cells absent diagnosis of a hematologic malignancy. Presence of CH in solid tumor patients, including colon cancer, correlates with shorter survival. We hypothesized that bone marrow–derived cells with heterozygous...

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Detalles Bibliográficos
Autores principales: Feng, Yang, Yuan, Qingchen, Newsome, Rachel C., Robinson, Troy, Bowman, Robert L., Zuniga, Ashley N., Hall, Kendra N., Bernsten, Cassandra M., Shabashvili, Daniil E., Krajcik, Kathryn I., Gunaratne, Chamara, Zaroogian, Zachary J., Venugopal, Kartika, Casellas Roman, Heidi L., Levine, Ross L., Chatila, Walid K., Yaeger, Rona, Riva, Alberto, Jobin, Christian, Kopinke, Daniel, Avram, Dorina, Guryanova, Olga A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450614/
https://www.ncbi.nlm.nih.gov/pubmed/37615936
http://dx.doi.org/10.1084/jem.20230011

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