Cargando…

BRCA1 heterozygosity promotes DNA damage-induced senescence in a sex-specific manner following repeated mild traumatic brain injury

Emerging evidence suggests cellular senescence, as a consequence of excess DNA damage and deficient repair, to be a driver of brain dysfunction following repeated mild traumatic brain injury (rmTBI). This study aimed to further investigate the role of deficient DNA repair, specifically BRCA1-related...

Descripción completa

Detalles Bibliográficos
Autores principales:	Leung, Emily, Taskina, Daria, Schwab, Nicole, Hazrati, Lili-Naz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450634/ https://www.ncbi.nlm.nih.gov/pubmed/37638313 http://dx.doi.org/10.3389/fnins.2023.1225226

Ejemplares similares

Neurons and glial cells acquire a senescent signature after repeated mild traumatic brain injury in a sex-dependent manner
por: Schwab, Nicole, et al.
Publicado: (2022)

Cellular Senescence in Traumatic Brain Injury: Evidence and Perspectives
por: Schwab, Nicole, et al.
Publicado: (2021)

Early onset senescence and cognitive impairment in a murine model of repeated mTBI
por: Schwab, Nicole, et al.
Publicado: (2021)

The pathological potential of ependymal cells in mild traumatic brain injury
por: Nelles, Diana G., et al.
Publicado: (2023)

Temporal patterns of microglial activation in white matter following experimental mild traumatic brain injury: a systematic literature review
por: Velayudhan, Prashanth S., et al.
Publicado: (2021)

DNA repair deficiency and senescence in concussed professional athletes involved in contact sports
por: Schwab, Nicole, et al.
Publicado: (2019)

BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers
por: Maxwell, Kara N., et al.
Publicado: (2017)

Repeated Mild Traumatic Brain Injury: Potential Mechanisms of Damage
por: Fehily, Brooke, et al.
Publicado: (2017)

Association of Position Played and Career Duration and Chronic Traumatic Encephalopathy at Autopsy in Elite Football and Hockey Players
por: Schwab, Nicole, et al.
Publicado: (2021)

Value of the loss of heterozygosity to BRCA1 variant classification
por: Santana dos Santos, Elizabeth, et al.
Publicado: (2022)

BRCA2 Heterozygosity Delays Cytokinesis in Primary Human Fibroblasts
por: Jonsdottir, Asta Björk, et al.
Publicado: (2009)

Breast cancer type 1 and neurodegeneration: consequences of deficient DNA repair
por: Leung, Emily, et al.
Publicado: (2021)

Clinical impact of detection of loss of heterozygosity of BRCA1 and BRCA2 markers in sporadic breast cancer.
por: Beckmann, M. W., et al.
Publicado: (1996)

Clinicopathological Characterization of Double Heterozygosity for BRCA1 and BRCA2 Variants in Korean Breast Cancer Patients
por: Bang, Yoon Ju, et al.
Publicado: (2022)

Prognostic value of loss of heterozygosity at BRCA2 in human breast carcinoma.
por: BiÃ¨che, I., et al.
Publicado: (1997)

Mechanisms of increased risk of tumorigenesis in Atm and Brca1 double heterozygosity
por: Wang, Jufang, et al.
Publicado: (2011)

Double Heterozygosity for Rare Deleterious Variants in the BRCA1 and BRCA2 Genes in a Hungarian Patient with Breast Cancer
por: Madar, László, et al.
Publicado: (2023)

Pan-Cancer Analysis of BRCA1 and BRCA2 Genomic Alterations and Their Association With Genomic Instability as Measured by Genome-Wide Loss of Heterozygosity
por: Sokol, Ethan S., et al.
Publicado: (2020)

Mapping loss of heterozygosity in normal human breast cells from BRCA1/2 carriers
por: Clarke, C L, et al.
Publicado: (2006)

Double Heterozygosity of BRCA2 and STK11 in Familial Breast Cancer Detected by Exome Sequencing
por: ATAEI-KACHOUEI, Mojgan, et al.
Publicado: (2015)

Repeated mild traumatic brain injury causes sex-specific increases in cell proliferation and inflammation in juvenile rats
por: Neale, Katie J., et al.
Publicado: (2023)

Detection of loss of heterozygosity at RAD51, RAD52, RAD54 and BRCA1 and BRCA2 loci in breast cancer: pathological correlations
por: Gonzalez, R, et al.
Publicado: (1999)

Loss of heterozygosity in sporadic breast tumours at the BRCA2 locus on chromosome 13q12-q13.
por: Cleton-Jansen, A. M., et al.
Publicado: (1995)

BRCA1/Trp53 heterozygosity and replication stress drive esophageal cancer development in a mouse model
por: He, Ye, et al.
Publicado: (2021)

Repeated mild traumatic brain injury can cause acute neurologic impairment without overt structural damage in juvenile rats
por: Meconi, Alicia, et al.
Publicado: (2018)

Ependymal cells and neurodegenerative disease: outcomes of compromised ependymal barrier function
por: Nelles, Diana G, et al.
Publicado: (2022)

Chronic traumatic encephalopathy and other neurodegenerative proteinopathies
por: Tartaglia, Maria Carmela, et al.
Publicado: (2014)

Curcumin induces senescence of primary human cells building the vasculature in a DNA damage and ATM-independent manner
por: Grabowska, Wioleta, et al.
Publicado: (2015)

Iron overload induces cerebral endothelial senescence in aged mice and in primary culture in a sex‐dependent manner
por: Noh, Brian, et al.
Publicado: (2023)

Double Heterozygosity for BRCA1 Pathogenic Variant and BRCA2 Polymorphic Stop Codon K3326X: A Case Report in a Southern Italian Family
por: Palmirotta, Raffaele, et al.
Publicado: (2018)

Chromatin remodeling, BRCA1, SAHF and cellular senescence
por: Tu, Zhigang, et al.
Publicado: (2013)

Exo70 intracellular redistribution after repeated mild traumatic brain injury
por: Lira, Matías, et al.
Publicado: (2021)

Repeated mild traumatic brain injury impairs fracture healing in male mice
por: Kesavan, Chandrasekhar, et al.
Publicado: (2022)

Mild and Moderate Traumatic Brain Injury and Repeated Stress Affect Corticosterone in the Rat
por: Rowe, Rachel K., et al.
Publicado: (2020)

Sex and manners : female emancipation in the West, 1890-2000 /
por: Wouters, Cas
Publicado: (2004)

Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivity
por: Chatterjee, Gouri, et al.
Publicado: (2016)

A new method to detect loss of heterozygosity using cohort heterozygosity comparisons
por: Green, Michael R, et al.
Publicado: (2010)

Sex matters: repetitive mild traumatic brain injury in adolescent rats
por: Wright, David K., et al.
Publicado: (2017)

Mitochondrial Dysfunction After Repeated Mild Blast Traumatic Brain Injury Is Attenuated by a Mild Mitochondrial Uncoupling Prodrug
por: Hubbard, W. Brad, et al.
Publicado: (2023)

Repeated mild traumatic brain injury causes focal response in lateral septum and hippocampus
por: Acabchuk, Rebecca, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_pf3fgmolnjuubvuruu6u9drcfb