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Exploring cuproptosis as a mechanism and potential intervention target in cardiovascular diseases
Copper (Cu) is a vital trace element for maintaining human health. Current evidence suggests that genes responsible for regulating copper influx and detoxification help preserve its homeostasis. Adequate Cu levels sustain normal cardiac and blood vessel activity by maintaining mitochondrial function...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450925/ https://www.ncbi.nlm.nih.gov/pubmed/37637426 http://dx.doi.org/10.3389/fphar.2023.1229297 |
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author | Yang, Yang Feng, Qi Luan, Ying Liu, Hui Jiao, Yuxue Hao, Huijie Yu, Bo Luan, Yi Ren, Kaidi |
author_facet | Yang, Yang Feng, Qi Luan, Ying Liu, Hui Jiao, Yuxue Hao, Huijie Yu, Bo Luan, Yi Ren, Kaidi |
author_sort | Yang, Yang |
collection | PubMed |
description | Copper (Cu) is a vital trace element for maintaining human health. Current evidence suggests that genes responsible for regulating copper influx and detoxification help preserve its homeostasis. Adequate Cu levels sustain normal cardiac and blood vessel activity by maintaining mitochondrial function. Cuproptosis, unlike other forms of cell death, is characterized by alterations in mitochondrial enzymes. Therapeutics targeting cuproptosis in cardiovascular diseases (CVDs) mainly include copper chelators, inhibitors of copper chaperone proteins, and copper ionophores. In this review, we expound on the primary mechanisms, critical proteins, and signaling pathways involved in cuproptosis, along with its impact on CVDs and the role it plays in different types of cells. Additionally, we explored the influence of key regulatory proteins and signaling pathways associated with cuproptosis on CVDs and determined whether intervening in copper metabolism and cuproptosis can enhance the outcomes of CVDs. The insights from this review provide a fresh perspective on the pathogenesis of CVDs and new targets for intervention in these diseases. |
format | Online Article Text |
id | pubmed-10450925 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104509252023-08-26 Exploring cuproptosis as a mechanism and potential intervention target in cardiovascular diseases Yang, Yang Feng, Qi Luan, Ying Liu, Hui Jiao, Yuxue Hao, Huijie Yu, Bo Luan, Yi Ren, Kaidi Front Pharmacol Pharmacology Copper (Cu) is a vital trace element for maintaining human health. Current evidence suggests that genes responsible for regulating copper influx and detoxification help preserve its homeostasis. Adequate Cu levels sustain normal cardiac and blood vessel activity by maintaining mitochondrial function. Cuproptosis, unlike other forms of cell death, is characterized by alterations in mitochondrial enzymes. Therapeutics targeting cuproptosis in cardiovascular diseases (CVDs) mainly include copper chelators, inhibitors of copper chaperone proteins, and copper ionophores. In this review, we expound on the primary mechanisms, critical proteins, and signaling pathways involved in cuproptosis, along with its impact on CVDs and the role it plays in different types of cells. Additionally, we explored the influence of key regulatory proteins and signaling pathways associated with cuproptosis on CVDs and determined whether intervening in copper metabolism and cuproptosis can enhance the outcomes of CVDs. The insights from this review provide a fresh perspective on the pathogenesis of CVDs and new targets for intervention in these diseases. Frontiers Media S.A. 2023-08-11 /pmc/articles/PMC10450925/ /pubmed/37637426 http://dx.doi.org/10.3389/fphar.2023.1229297 Text en Copyright © 2023 Yang, Feng, Luan, Liu, Jiao, Hao, Yu, Luan and Ren. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Yang, Yang Feng, Qi Luan, Ying Liu, Hui Jiao, Yuxue Hao, Huijie Yu, Bo Luan, Yi Ren, Kaidi Exploring cuproptosis as a mechanism and potential intervention target in cardiovascular diseases |
title | Exploring cuproptosis as a mechanism and potential intervention target in cardiovascular diseases |
title_full | Exploring cuproptosis as a mechanism and potential intervention target in cardiovascular diseases |
title_fullStr | Exploring cuproptosis as a mechanism and potential intervention target in cardiovascular diseases |
title_full_unstemmed | Exploring cuproptosis as a mechanism and potential intervention target in cardiovascular diseases |
title_short | Exploring cuproptosis as a mechanism and potential intervention target in cardiovascular diseases |
title_sort | exploring cuproptosis as a mechanism and potential intervention target in cardiovascular diseases |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450925/ https://www.ncbi.nlm.nih.gov/pubmed/37637426 http://dx.doi.org/10.3389/fphar.2023.1229297 |
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