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Cellular heterogeneity and plasticity during NAFLD progression

Nonalcoholic fatty liver disease (NAFLD) is a progressive liver disease that can progress to nonalcoholic steatohepatitis (NASH), NASH-related cirrhosis, and hepatocellular carcinoma (HCC). NAFLD ranges from simple steatosis (or nonalcoholic fatty liver [NAFL]) to NASH as a progressive form of NAFL,...

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Autores principales: Park, Hyun-Ju, Choi, Juyoung, Kim, Hyunmi, Yang, Da-Yeon, An, Tae Hyeon, Lee, Eun-Woo, Han, Baek-Soo, Lee, Sang Chul, Kim, Won Kon, Bae, Kwang-Hee, Oh, Kyoung-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450943/
https://www.ncbi.nlm.nih.gov/pubmed/37635938
http://dx.doi.org/10.3389/fmolb.2023.1221669
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author Park, Hyun-Ju
Choi, Juyoung
Kim, Hyunmi
Yang, Da-Yeon
An, Tae Hyeon
Lee, Eun-Woo
Han, Baek-Soo
Lee, Sang Chul
Kim, Won Kon
Bae, Kwang-Hee
Oh, Kyoung-Jin
author_facet Park, Hyun-Ju
Choi, Juyoung
Kim, Hyunmi
Yang, Da-Yeon
An, Tae Hyeon
Lee, Eun-Woo
Han, Baek-Soo
Lee, Sang Chul
Kim, Won Kon
Bae, Kwang-Hee
Oh, Kyoung-Jin
author_sort Park, Hyun-Ju
collection PubMed
description Nonalcoholic fatty liver disease (NAFLD) is a progressive liver disease that can progress to nonalcoholic steatohepatitis (NASH), NASH-related cirrhosis, and hepatocellular carcinoma (HCC). NAFLD ranges from simple steatosis (or nonalcoholic fatty liver [NAFL]) to NASH as a progressive form of NAFL, which is characterized by steatosis, lobular inflammation, and hepatocellular ballooning with or without fibrosis. Because of the complex pathophysiological mechanism and the heterogeneity of NAFLD, including its wide spectrum of clinical and histological characteristics, no specific therapeutic drugs have been approved for NAFLD. The heterogeneity of NAFLD is closely associated with cellular plasticity, which describes the ability of cells to acquire new identities or change their phenotypes in response to environmental stimuli. The liver consists of parenchymal cells including hepatocytes and cholangiocytes and nonparenchymal cells including Kupffer cells, hepatic stellate cells, and endothelial cells, all of which have specialized functions. This heterogeneous cell population has cellular plasticity to adapt to environmental changes. During NAFLD progression, these cells can exert diverse and complex responses at multiple levels following exposure to a variety of stimuli, including fatty acids, inflammation, and oxidative stress. Therefore, this review provides insights into NAFLD heterogeneity by addressing the cellular plasticity and metabolic adaptation of hepatocytes, cholangiocytes, hepatic stellate cells, and Kupffer cells during NAFLD progression.
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spelling pubmed-104509432023-08-26 Cellular heterogeneity and plasticity during NAFLD progression Park, Hyun-Ju Choi, Juyoung Kim, Hyunmi Yang, Da-Yeon An, Tae Hyeon Lee, Eun-Woo Han, Baek-Soo Lee, Sang Chul Kim, Won Kon Bae, Kwang-Hee Oh, Kyoung-Jin Front Mol Biosci Molecular Biosciences Nonalcoholic fatty liver disease (NAFLD) is a progressive liver disease that can progress to nonalcoholic steatohepatitis (NASH), NASH-related cirrhosis, and hepatocellular carcinoma (HCC). NAFLD ranges from simple steatosis (or nonalcoholic fatty liver [NAFL]) to NASH as a progressive form of NAFL, which is characterized by steatosis, lobular inflammation, and hepatocellular ballooning with or without fibrosis. Because of the complex pathophysiological mechanism and the heterogeneity of NAFLD, including its wide spectrum of clinical and histological characteristics, no specific therapeutic drugs have been approved for NAFLD. The heterogeneity of NAFLD is closely associated with cellular plasticity, which describes the ability of cells to acquire new identities or change their phenotypes in response to environmental stimuli. The liver consists of parenchymal cells including hepatocytes and cholangiocytes and nonparenchymal cells including Kupffer cells, hepatic stellate cells, and endothelial cells, all of which have specialized functions. This heterogeneous cell population has cellular plasticity to adapt to environmental changes. During NAFLD progression, these cells can exert diverse and complex responses at multiple levels following exposure to a variety of stimuli, including fatty acids, inflammation, and oxidative stress. Therefore, this review provides insights into NAFLD heterogeneity by addressing the cellular plasticity and metabolic adaptation of hepatocytes, cholangiocytes, hepatic stellate cells, and Kupffer cells during NAFLD progression. Frontiers Media S.A. 2023-08-11 /pmc/articles/PMC10450943/ /pubmed/37635938 http://dx.doi.org/10.3389/fmolb.2023.1221669 Text en Copyright © 2023 Park, Choi, Kim, Yang, An, Lee, Han, Lee, Kim, Bae and Oh. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Park, Hyun-Ju
Choi, Juyoung
Kim, Hyunmi
Yang, Da-Yeon
An, Tae Hyeon
Lee, Eun-Woo
Han, Baek-Soo
Lee, Sang Chul
Kim, Won Kon
Bae, Kwang-Hee
Oh, Kyoung-Jin
Cellular heterogeneity and plasticity during NAFLD progression
title Cellular heterogeneity and plasticity during NAFLD progression
title_full Cellular heterogeneity and plasticity during NAFLD progression
title_fullStr Cellular heterogeneity and plasticity during NAFLD progression
title_full_unstemmed Cellular heterogeneity and plasticity during NAFLD progression
title_short Cellular heterogeneity and plasticity during NAFLD progression
title_sort cellular heterogeneity and plasticity during nafld progression
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450943/
https://www.ncbi.nlm.nih.gov/pubmed/37635938
http://dx.doi.org/10.3389/fmolb.2023.1221669
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