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Microbial Landscape and Antibiotic-Susceptibility Profiles of Microorganisms in Patients with Bacterial Pneumonia: A Comparative Cross-Sectional Study of COVID-19 and Non-COVID-19 Cases in Aktobe, Kazakhstan

This cross-sectional study investigated the microbial landscape and antibiotic-resistance patterns in patients with bacterial pneumonia, with a focus on the impact of COVID-19. Sputum samples from individuals with bacterial pneumonia, including coronavirus disease 2019-positive polymerase chain reac...

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Autores principales: Ablakimova, Nurgul, Mussina, Aigul Z., Smagulova, Gaziza A., Rachina, Svetlana, Kurmangazin, Meirambek S., Balapasheva, Aigerim, Karimoldayeva, Dinara, Zare, Afshin, Mahdipour, Mahdi, Rahmanifar, Farhad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451206/
https://www.ncbi.nlm.nih.gov/pubmed/37627717
http://dx.doi.org/10.3390/antibiotics12081297
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author Ablakimova, Nurgul
Mussina, Aigul Z.
Smagulova, Gaziza A.
Rachina, Svetlana
Kurmangazin, Meirambek S.
Balapasheva, Aigerim
Karimoldayeva, Dinara
Zare, Afshin
Mahdipour, Mahdi
Rahmanifar, Farhad
author_facet Ablakimova, Nurgul
Mussina, Aigul Z.
Smagulova, Gaziza A.
Rachina, Svetlana
Kurmangazin, Meirambek S.
Balapasheva, Aigerim
Karimoldayeva, Dinara
Zare, Afshin
Mahdipour, Mahdi
Rahmanifar, Farhad
author_sort Ablakimova, Nurgul
collection PubMed
description This cross-sectional study investigated the microbial landscape and antibiotic-resistance patterns in patients with bacterial pneumonia, with a focus on the impact of COVID-19. Sputum samples from individuals with bacterial pneumonia, including coronavirus disease 2019-positive polymerase chain reaction (COVID-19-PCR+), COVID-19-PCR− and non-COVID-19 patients, were analyzed. Surprisingly, the classic etiological factor of bacterial pneumonia, Streptococcus pneumoniae, was rarely isolated from the sputum samples. Furthermore, the frequency of multidrug-resistant pathogens was found to be higher in non-COVID-19 patients, highlighting the potential impact of the pandemic on antimicrobial resistance. Strains obtained from COVID-19-PCR+ patients exhibited significant resistance to commonly used antibiotics, including fluoroquinolones and cephalosporins. Notably, the ESKAPE pathogens, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterobacter cloacae, and Enterobacter aerogenes, were identified among the isolated microorganisms. Our findings underscore the urgent need for infection control measures and responsible antibiotic use in healthcare settings, as well as the importance of enhancing pneumonia diagnostics and implementing standardized laboratory protocols.
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spelling pubmed-104512062023-08-26 Microbial Landscape and Antibiotic-Susceptibility Profiles of Microorganisms in Patients with Bacterial Pneumonia: A Comparative Cross-Sectional Study of COVID-19 and Non-COVID-19 Cases in Aktobe, Kazakhstan Ablakimova, Nurgul Mussina, Aigul Z. Smagulova, Gaziza A. Rachina, Svetlana Kurmangazin, Meirambek S. Balapasheva, Aigerim Karimoldayeva, Dinara Zare, Afshin Mahdipour, Mahdi Rahmanifar, Farhad Antibiotics (Basel) Article This cross-sectional study investigated the microbial landscape and antibiotic-resistance patterns in patients with bacterial pneumonia, with a focus on the impact of COVID-19. Sputum samples from individuals with bacterial pneumonia, including coronavirus disease 2019-positive polymerase chain reaction (COVID-19-PCR+), COVID-19-PCR− and non-COVID-19 patients, were analyzed. Surprisingly, the classic etiological factor of bacterial pneumonia, Streptococcus pneumoniae, was rarely isolated from the sputum samples. Furthermore, the frequency of multidrug-resistant pathogens was found to be higher in non-COVID-19 patients, highlighting the potential impact of the pandemic on antimicrobial resistance. Strains obtained from COVID-19-PCR+ patients exhibited significant resistance to commonly used antibiotics, including fluoroquinolones and cephalosporins. Notably, the ESKAPE pathogens, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterobacter cloacae, and Enterobacter aerogenes, were identified among the isolated microorganisms. Our findings underscore the urgent need for infection control measures and responsible antibiotic use in healthcare settings, as well as the importance of enhancing pneumonia diagnostics and implementing standardized laboratory protocols. MDPI 2023-08-08 /pmc/articles/PMC10451206/ /pubmed/37627717 http://dx.doi.org/10.3390/antibiotics12081297 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ablakimova, Nurgul
Mussina, Aigul Z.
Smagulova, Gaziza A.
Rachina, Svetlana
Kurmangazin, Meirambek S.
Balapasheva, Aigerim
Karimoldayeva, Dinara
Zare, Afshin
Mahdipour, Mahdi
Rahmanifar, Farhad
Microbial Landscape and Antibiotic-Susceptibility Profiles of Microorganisms in Patients with Bacterial Pneumonia: A Comparative Cross-Sectional Study of COVID-19 and Non-COVID-19 Cases in Aktobe, Kazakhstan
title Microbial Landscape and Antibiotic-Susceptibility Profiles of Microorganisms in Patients with Bacterial Pneumonia: A Comparative Cross-Sectional Study of COVID-19 and Non-COVID-19 Cases in Aktobe, Kazakhstan
title_full Microbial Landscape and Antibiotic-Susceptibility Profiles of Microorganisms in Patients with Bacterial Pneumonia: A Comparative Cross-Sectional Study of COVID-19 and Non-COVID-19 Cases in Aktobe, Kazakhstan
title_fullStr Microbial Landscape and Antibiotic-Susceptibility Profiles of Microorganisms in Patients with Bacterial Pneumonia: A Comparative Cross-Sectional Study of COVID-19 and Non-COVID-19 Cases in Aktobe, Kazakhstan
title_full_unstemmed Microbial Landscape and Antibiotic-Susceptibility Profiles of Microorganisms in Patients with Bacterial Pneumonia: A Comparative Cross-Sectional Study of COVID-19 and Non-COVID-19 Cases in Aktobe, Kazakhstan
title_short Microbial Landscape and Antibiotic-Susceptibility Profiles of Microorganisms in Patients with Bacterial Pneumonia: A Comparative Cross-Sectional Study of COVID-19 and Non-COVID-19 Cases in Aktobe, Kazakhstan
title_sort microbial landscape and antibiotic-susceptibility profiles of microorganisms in patients with bacterial pneumonia: a comparative cross-sectional study of covid-19 and non-covid-19 cases in aktobe, kazakhstan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451206/
https://www.ncbi.nlm.nih.gov/pubmed/37627717
http://dx.doi.org/10.3390/antibiotics12081297
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