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Cross-Talk of NADPH Oxidases and Inflammation in Obesity

Obesity is a major risk factor for cardiovascular and metabolic diseases. Multiple experimental and clinical studies have shown increased oxidative stress and inflammation linked to obesity. NADPH oxidases are major sources of reactive oxygen species in the cardiovascular system and in metabolically...

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Autores principales: Morawietz, Henning, Brendel, Heike, Diaba-Nuhoho, Patrick, Catar, Rusan, Perakakis, Nikolaos, Wolfrum, Christian, Bornstein, Stefan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451527/
https://www.ncbi.nlm.nih.gov/pubmed/37627585
http://dx.doi.org/10.3390/antiox12081589
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author Morawietz, Henning
Brendel, Heike
Diaba-Nuhoho, Patrick
Catar, Rusan
Perakakis, Nikolaos
Wolfrum, Christian
Bornstein, Stefan R.
author_facet Morawietz, Henning
Brendel, Heike
Diaba-Nuhoho, Patrick
Catar, Rusan
Perakakis, Nikolaos
Wolfrum, Christian
Bornstein, Stefan R.
author_sort Morawietz, Henning
collection PubMed
description Obesity is a major risk factor for cardiovascular and metabolic diseases. Multiple experimental and clinical studies have shown increased oxidative stress and inflammation linked to obesity. NADPH oxidases are major sources of reactive oxygen species in the cardiovascular system and in metabolically active cells and organs. An impaired balance due to the increased formation of reactive oxygen species and a reduced antioxidative capacity contributes to the pathophysiology of cardiovascular and metabolic diseases and is linked to inflammation as a major pathomechanism in cardiometabolic diseases. Non-alcoholic fatty liver disease is particularly characterized by increased oxidative stress and inflammation. In recent years, COVID-19 infections have also increased oxidative stress and inflammation in infected cells and tissues. Increasing evidence supports the idea of an increased risk for severe clinical complications of cardiometabolic diseases after COVID-19. In this review, we discuss the role of oxidative stress and inflammation in experimental models and clinical studies of obesity, cardiovascular diseases, COVID-19 infections and potential therapeutic strategies.
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spelling pubmed-104515272023-08-26 Cross-Talk of NADPH Oxidases and Inflammation in Obesity Morawietz, Henning Brendel, Heike Diaba-Nuhoho, Patrick Catar, Rusan Perakakis, Nikolaos Wolfrum, Christian Bornstein, Stefan R. Antioxidants (Basel) Review Obesity is a major risk factor for cardiovascular and metabolic diseases. Multiple experimental and clinical studies have shown increased oxidative stress and inflammation linked to obesity. NADPH oxidases are major sources of reactive oxygen species in the cardiovascular system and in metabolically active cells and organs. An impaired balance due to the increased formation of reactive oxygen species and a reduced antioxidative capacity contributes to the pathophysiology of cardiovascular and metabolic diseases and is linked to inflammation as a major pathomechanism in cardiometabolic diseases. Non-alcoholic fatty liver disease is particularly characterized by increased oxidative stress and inflammation. In recent years, COVID-19 infections have also increased oxidative stress and inflammation in infected cells and tissues. Increasing evidence supports the idea of an increased risk for severe clinical complications of cardiometabolic diseases after COVID-19. In this review, we discuss the role of oxidative stress and inflammation in experimental models and clinical studies of obesity, cardiovascular diseases, COVID-19 infections and potential therapeutic strategies. MDPI 2023-08-09 /pmc/articles/PMC10451527/ /pubmed/37627585 http://dx.doi.org/10.3390/antiox12081589 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Morawietz, Henning
Brendel, Heike
Diaba-Nuhoho, Patrick
Catar, Rusan
Perakakis, Nikolaos
Wolfrum, Christian
Bornstein, Stefan R.
Cross-Talk of NADPH Oxidases and Inflammation in Obesity
title Cross-Talk of NADPH Oxidases and Inflammation in Obesity
title_full Cross-Talk of NADPH Oxidases and Inflammation in Obesity
title_fullStr Cross-Talk of NADPH Oxidases and Inflammation in Obesity
title_full_unstemmed Cross-Talk of NADPH Oxidases and Inflammation in Obesity
title_short Cross-Talk of NADPH Oxidases and Inflammation in Obesity
title_sort cross-talk of nadph oxidases and inflammation in obesity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451527/
https://www.ncbi.nlm.nih.gov/pubmed/37627585
http://dx.doi.org/10.3390/antiox12081589
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