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The Silent Threat to Women’s Fertility: Uncovering the Devastating Effects of Oxidative Stress

Oxidative stress (OS), which arises through an imbalance between the formation of reactive oxygen species (ROS) and antioxidant defenses, plays a key role in the pathophysiology of female infertility, with the latter constituting just one of a number of diseases linked to OS as a potential cause. Th...

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Autores principales: Kaltsas, Aris, Zikopoulos, Athanasios, Moustakli, Efthalia, Zachariou, Athanasios, Tsirka, Georgia, Tsiampali, Chara, Palapela, Natalia, Sofikitis, Nikolaos, Dimitriadis, Fotios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451552/
https://www.ncbi.nlm.nih.gov/pubmed/37627485
http://dx.doi.org/10.3390/antiox12081490
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author Kaltsas, Aris
Zikopoulos, Athanasios
Moustakli, Efthalia
Zachariou, Athanasios
Tsirka, Georgia
Tsiampali, Chara
Palapela, Natalia
Sofikitis, Nikolaos
Dimitriadis, Fotios
author_facet Kaltsas, Aris
Zikopoulos, Athanasios
Moustakli, Efthalia
Zachariou, Athanasios
Tsirka, Georgia
Tsiampali, Chara
Palapela, Natalia
Sofikitis, Nikolaos
Dimitriadis, Fotios
author_sort Kaltsas, Aris
collection PubMed
description Oxidative stress (OS), which arises through an imbalance between the formation of reactive oxygen species (ROS) and antioxidant defenses, plays a key role in the pathophysiology of female infertility, with the latter constituting just one of a number of diseases linked to OS as a potential cause. The aim of the present article is to review the literature regarding the association between OS and female infertility. Among the reproductive diseases considered are endometriosis and polycystic ovary syndrome (PCOS), while environmental pollutants, lifestyle variables, and underlying medical conditions possibly resulting in OS are additionally examined. Current evidence points to OS likely contributing to the pathophysiology of the above reproductive disorders, with the amount of damage done by OS being influenced by such variables as duration and severity of exposure and the individual’s age and genetic predisposition. Also discussed are the processes via which OS may affect female fertility, these including DNA damage and mitochondrial dysfunction. Finally, the last section of the manuscript contains an evaluation of treatment options, including antioxidants and lifestyle modification, capable of minimizing OS in infertile women. The prime message underlined by this review is the importance of considering OS in the diagnosis and treatment of female infertility. Further studies are, nevertheless required to identify the best treatment regimen and its ideal duration.
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spelling pubmed-104515522023-08-26 The Silent Threat to Women’s Fertility: Uncovering the Devastating Effects of Oxidative Stress Kaltsas, Aris Zikopoulos, Athanasios Moustakli, Efthalia Zachariou, Athanasios Tsirka, Georgia Tsiampali, Chara Palapela, Natalia Sofikitis, Nikolaos Dimitriadis, Fotios Antioxidants (Basel) Review Oxidative stress (OS), which arises through an imbalance between the formation of reactive oxygen species (ROS) and antioxidant defenses, plays a key role in the pathophysiology of female infertility, with the latter constituting just one of a number of diseases linked to OS as a potential cause. The aim of the present article is to review the literature regarding the association between OS and female infertility. Among the reproductive diseases considered are endometriosis and polycystic ovary syndrome (PCOS), while environmental pollutants, lifestyle variables, and underlying medical conditions possibly resulting in OS are additionally examined. Current evidence points to OS likely contributing to the pathophysiology of the above reproductive disorders, with the amount of damage done by OS being influenced by such variables as duration and severity of exposure and the individual’s age and genetic predisposition. Also discussed are the processes via which OS may affect female fertility, these including DNA damage and mitochondrial dysfunction. Finally, the last section of the manuscript contains an evaluation of treatment options, including antioxidants and lifestyle modification, capable of minimizing OS in infertile women. The prime message underlined by this review is the importance of considering OS in the diagnosis and treatment of female infertility. Further studies are, nevertheless required to identify the best treatment regimen and its ideal duration. MDPI 2023-07-26 /pmc/articles/PMC10451552/ /pubmed/37627485 http://dx.doi.org/10.3390/antiox12081490 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kaltsas, Aris
Zikopoulos, Athanasios
Moustakli, Efthalia
Zachariou, Athanasios
Tsirka, Georgia
Tsiampali, Chara
Palapela, Natalia
Sofikitis, Nikolaos
Dimitriadis, Fotios
The Silent Threat to Women’s Fertility: Uncovering the Devastating Effects of Oxidative Stress
title The Silent Threat to Women’s Fertility: Uncovering the Devastating Effects of Oxidative Stress
title_full The Silent Threat to Women’s Fertility: Uncovering the Devastating Effects of Oxidative Stress
title_fullStr The Silent Threat to Women’s Fertility: Uncovering the Devastating Effects of Oxidative Stress
title_full_unstemmed The Silent Threat to Women’s Fertility: Uncovering the Devastating Effects of Oxidative Stress
title_short The Silent Threat to Women’s Fertility: Uncovering the Devastating Effects of Oxidative Stress
title_sort silent threat to women’s fertility: uncovering the devastating effects of oxidative stress
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451552/
https://www.ncbi.nlm.nih.gov/pubmed/37627485
http://dx.doi.org/10.3390/antiox12081490
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