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Computational Biomechanics of Sleep: A Systematic Mapping Review

Biomechanical studies play an important role in understanding the pathophysiology of sleep disorders and providing insights to maintain sleep health. Computational methods facilitate a versatile platform to analyze various biomechanical factors in silico, which would otherwise be difficult through i...

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Autores principales: Cheng, Ethan Shiu-Wang, Lai, Derek Ka-Hei, Mao, Ye-Jiao, Lee, Timothy Tin-Yan, Lam, Wing-Kai, Cheung, James Chung-Wai, Wong, Duo Wai-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451553/
https://www.ncbi.nlm.nih.gov/pubmed/37627802
http://dx.doi.org/10.3390/bioengineering10080917
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author Cheng, Ethan Shiu-Wang
Lai, Derek Ka-Hei
Mao, Ye-Jiao
Lee, Timothy Tin-Yan
Lam, Wing-Kai
Cheung, James Chung-Wai
Wong, Duo Wai-Chi
author_facet Cheng, Ethan Shiu-Wang
Lai, Derek Ka-Hei
Mao, Ye-Jiao
Lee, Timothy Tin-Yan
Lam, Wing-Kai
Cheung, James Chung-Wai
Wong, Duo Wai-Chi
author_sort Cheng, Ethan Shiu-Wang
collection PubMed
description Biomechanical studies play an important role in understanding the pathophysiology of sleep disorders and providing insights to maintain sleep health. Computational methods facilitate a versatile platform to analyze various biomechanical factors in silico, which would otherwise be difficult through in vivo experiments. The objective of this review is to examine and map the applications of computational biomechanics to sleep-related research topics, including sleep medicine and sleep ergonomics. A systematic search was conducted on PubMed, Scopus, and Web of Science. Research gaps were identified through data synthesis on variants, outcomes, and highlighted features, as well as evidence maps on basic modeling considerations and modeling components of the eligible studies. Twenty-seven studies (n = 27) were categorized into sleep ergonomics (n = 2 on pillow; n = 3 on mattress), sleep-related breathing disorders (n = 19 on obstructive sleep apnea), and sleep-related movement disorders (n = 3 on sleep bruxism). The effects of pillow height and mattress stiffness on spinal curvature were explored. Stress on the temporomandibular joint, and therefore its disorder, was the primary focus of investigations on sleep bruxism. Using finite element morphometry and fluid–structure interaction, studies on obstructive sleep apnea investigated the effects of anatomical variations, muscle activation of the tongue and soft palate, and gravitational direction on the collapse and blockade of the upper airway, in addition to the airflow pressure distribution. Model validation has been one of the greatest hurdles, while single-subject design and surrogate techniques have led to concerns about external validity. Future research might endeavor to reconstruct patient-specific models with patient-specific loading profiles in a larger cohort. Studies on sleep ergonomics research may pave the way for determining ideal spine curvature, in addition to simulating side-lying sleep postures. Sleep bruxism studies may analyze the accumulated dental damage and wear. Research on OSA treatments using computational approaches warrants further investigation.
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spelling pubmed-104515532023-08-26 Computational Biomechanics of Sleep: A Systematic Mapping Review Cheng, Ethan Shiu-Wang Lai, Derek Ka-Hei Mao, Ye-Jiao Lee, Timothy Tin-Yan Lam, Wing-Kai Cheung, James Chung-Wai Wong, Duo Wai-Chi Bioengineering (Basel) Review Biomechanical studies play an important role in understanding the pathophysiology of sleep disorders and providing insights to maintain sleep health. Computational methods facilitate a versatile platform to analyze various biomechanical factors in silico, which would otherwise be difficult through in vivo experiments. The objective of this review is to examine and map the applications of computational biomechanics to sleep-related research topics, including sleep medicine and sleep ergonomics. A systematic search was conducted on PubMed, Scopus, and Web of Science. Research gaps were identified through data synthesis on variants, outcomes, and highlighted features, as well as evidence maps on basic modeling considerations and modeling components of the eligible studies. Twenty-seven studies (n = 27) were categorized into sleep ergonomics (n = 2 on pillow; n = 3 on mattress), sleep-related breathing disorders (n = 19 on obstructive sleep apnea), and sleep-related movement disorders (n = 3 on sleep bruxism). The effects of pillow height and mattress stiffness on spinal curvature were explored. Stress on the temporomandibular joint, and therefore its disorder, was the primary focus of investigations on sleep bruxism. Using finite element morphometry and fluid–structure interaction, studies on obstructive sleep apnea investigated the effects of anatomical variations, muscle activation of the tongue and soft palate, and gravitational direction on the collapse and blockade of the upper airway, in addition to the airflow pressure distribution. Model validation has been one of the greatest hurdles, while single-subject design and surrogate techniques have led to concerns about external validity. Future research might endeavor to reconstruct patient-specific models with patient-specific loading profiles in a larger cohort. Studies on sleep ergonomics research may pave the way for determining ideal spine curvature, in addition to simulating side-lying sleep postures. Sleep bruxism studies may analyze the accumulated dental damage and wear. Research on OSA treatments using computational approaches warrants further investigation. MDPI 2023-08-02 /pmc/articles/PMC10451553/ /pubmed/37627802 http://dx.doi.org/10.3390/bioengineering10080917 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cheng, Ethan Shiu-Wang
Lai, Derek Ka-Hei
Mao, Ye-Jiao
Lee, Timothy Tin-Yan
Lam, Wing-Kai
Cheung, James Chung-Wai
Wong, Duo Wai-Chi
Computational Biomechanics of Sleep: A Systematic Mapping Review
title Computational Biomechanics of Sleep: A Systematic Mapping Review
title_full Computational Biomechanics of Sleep: A Systematic Mapping Review
title_fullStr Computational Biomechanics of Sleep: A Systematic Mapping Review
title_full_unstemmed Computational Biomechanics of Sleep: A Systematic Mapping Review
title_short Computational Biomechanics of Sleep: A Systematic Mapping Review
title_sort computational biomechanics of sleep: a systematic mapping review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451553/
https://www.ncbi.nlm.nih.gov/pubmed/37627802
http://dx.doi.org/10.3390/bioengineering10080917
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