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AI-Based Cancer Detection Model for Contrast-Enhanced Mammography

Background: The recent development of deep neural network models for the analysis of breast images has been a breakthrough in computer-aided diagnostics (CAD). Contrast-enhanced mammography (CEM) is a recent mammography modality providing anatomical and functional imaging of the breast. Despite the...

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Autores principales: Jailin, Clément, Mohamed, Sara, Iordache, Razvan, Milioni De Carvalho, Pablo, Ahmed, Salwa Yehia, Abdel Sattar, Engy Abdullah, Moustafa, Amr Farouk Ibrahim, Gomaa, Mohammed Mohammed, Kamal, Rashaa Mohammed, Vancamberg, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451612/
https://www.ncbi.nlm.nih.gov/pubmed/37627859
http://dx.doi.org/10.3390/bioengineering10080974
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author Jailin, Clément
Mohamed, Sara
Iordache, Razvan
Milioni De Carvalho, Pablo
Ahmed, Salwa Yehia
Abdel Sattar, Engy Abdullah
Moustafa, Amr Farouk Ibrahim
Gomaa, Mohammed Mohammed
Kamal, Rashaa Mohammed
Vancamberg, Laurence
author_facet Jailin, Clément
Mohamed, Sara
Iordache, Razvan
Milioni De Carvalho, Pablo
Ahmed, Salwa Yehia
Abdel Sattar, Engy Abdullah
Moustafa, Amr Farouk Ibrahim
Gomaa, Mohammed Mohammed
Kamal, Rashaa Mohammed
Vancamberg, Laurence
author_sort Jailin, Clément
collection PubMed
description Background: The recent development of deep neural network models for the analysis of breast images has been a breakthrough in computer-aided diagnostics (CAD). Contrast-enhanced mammography (CEM) is a recent mammography modality providing anatomical and functional imaging of the breast. Despite the clinical benefits it could bring, only a few research studies have been conducted around deep-learning (DL) based CAD for CEM, especially because the access to large databases is still limited. This study presents the development and evaluation of a CEM-CAD for enhancing lesion detection and breast classification. Materials & Methods: A deep learning enhanced cancer detection model based on a YOLO architecture has been optimized and trained on a large CEM dataset of 1673 patients (7443 images) with biopsy-proven lesions from various hospitals and acquisition systems. The evaluation was conducted using metrics derived from the free receiver operating characteristic (FROC) for the lesion detection and the receiver operating characteristic (ROC) to evaluate the overall breast classification performance. The performances were evaluated for different types of image input and for each patient background parenchymal enhancement (BPE) level. Results: The optimized model achieved an area under the curve (AUROC) of 0.964 for breast classification. Using both low-energy and recombined image as inputs for the DL model shows greater performance than using only the recombined image. For the lesion detection, the model was able to detect 90% of all cancers with a false positive (non-cancer) rate of 0.128 per image. This study demonstrates a high impact of BPE on classification and detection performance. Conclusion: The developed CEM CAD outperforms previously published papers and its performance is comparable to radiologist-reported classification and detection capability.
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spelling pubmed-104516122023-08-26 AI-Based Cancer Detection Model for Contrast-Enhanced Mammography Jailin, Clément Mohamed, Sara Iordache, Razvan Milioni De Carvalho, Pablo Ahmed, Salwa Yehia Abdel Sattar, Engy Abdullah Moustafa, Amr Farouk Ibrahim Gomaa, Mohammed Mohammed Kamal, Rashaa Mohammed Vancamberg, Laurence Bioengineering (Basel) Article Background: The recent development of deep neural network models for the analysis of breast images has been a breakthrough in computer-aided diagnostics (CAD). Contrast-enhanced mammography (CEM) is a recent mammography modality providing anatomical and functional imaging of the breast. Despite the clinical benefits it could bring, only a few research studies have been conducted around deep-learning (DL) based CAD for CEM, especially because the access to large databases is still limited. This study presents the development and evaluation of a CEM-CAD for enhancing lesion detection and breast classification. Materials & Methods: A deep learning enhanced cancer detection model based on a YOLO architecture has been optimized and trained on a large CEM dataset of 1673 patients (7443 images) with biopsy-proven lesions from various hospitals and acquisition systems. The evaluation was conducted using metrics derived from the free receiver operating characteristic (FROC) for the lesion detection and the receiver operating characteristic (ROC) to evaluate the overall breast classification performance. The performances were evaluated for different types of image input and for each patient background parenchymal enhancement (BPE) level. Results: The optimized model achieved an area under the curve (AUROC) of 0.964 for breast classification. Using both low-energy and recombined image as inputs for the DL model shows greater performance than using only the recombined image. For the lesion detection, the model was able to detect 90% of all cancers with a false positive (non-cancer) rate of 0.128 per image. This study demonstrates a high impact of BPE on classification and detection performance. Conclusion: The developed CEM CAD outperforms previously published papers and its performance is comparable to radiologist-reported classification and detection capability. MDPI 2023-08-17 /pmc/articles/PMC10451612/ /pubmed/37627859 http://dx.doi.org/10.3390/bioengineering10080974 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jailin, Clément
Mohamed, Sara
Iordache, Razvan
Milioni De Carvalho, Pablo
Ahmed, Salwa Yehia
Abdel Sattar, Engy Abdullah
Moustafa, Amr Farouk Ibrahim
Gomaa, Mohammed Mohammed
Kamal, Rashaa Mohammed
Vancamberg, Laurence
AI-Based Cancer Detection Model for Contrast-Enhanced Mammography
title AI-Based Cancer Detection Model for Contrast-Enhanced Mammography
title_full AI-Based Cancer Detection Model for Contrast-Enhanced Mammography
title_fullStr AI-Based Cancer Detection Model for Contrast-Enhanced Mammography
title_full_unstemmed AI-Based Cancer Detection Model for Contrast-Enhanced Mammography
title_short AI-Based Cancer Detection Model for Contrast-Enhanced Mammography
title_sort ai-based cancer detection model for contrast-enhanced mammography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451612/
https://www.ncbi.nlm.nih.gov/pubmed/37627859
http://dx.doi.org/10.3390/bioengineering10080974
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