Cargando…
AI-Based Cancer Detection Model for Contrast-Enhanced Mammography
Background: The recent development of deep neural network models for the analysis of breast images has been a breakthrough in computer-aided diagnostics (CAD). Contrast-enhanced mammography (CEM) is a recent mammography modality providing anatomical and functional imaging of the breast. Despite the...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451612/ https://www.ncbi.nlm.nih.gov/pubmed/37627859 http://dx.doi.org/10.3390/bioengineering10080974 |
_version_ | 1785095453074784256 |
---|---|
author | Jailin, Clément Mohamed, Sara Iordache, Razvan Milioni De Carvalho, Pablo Ahmed, Salwa Yehia Abdel Sattar, Engy Abdullah Moustafa, Amr Farouk Ibrahim Gomaa, Mohammed Mohammed Kamal, Rashaa Mohammed Vancamberg, Laurence |
author_facet | Jailin, Clément Mohamed, Sara Iordache, Razvan Milioni De Carvalho, Pablo Ahmed, Salwa Yehia Abdel Sattar, Engy Abdullah Moustafa, Amr Farouk Ibrahim Gomaa, Mohammed Mohammed Kamal, Rashaa Mohammed Vancamberg, Laurence |
author_sort | Jailin, Clément |
collection | PubMed |
description | Background: The recent development of deep neural network models for the analysis of breast images has been a breakthrough in computer-aided diagnostics (CAD). Contrast-enhanced mammography (CEM) is a recent mammography modality providing anatomical and functional imaging of the breast. Despite the clinical benefits it could bring, only a few research studies have been conducted around deep-learning (DL) based CAD for CEM, especially because the access to large databases is still limited. This study presents the development and evaluation of a CEM-CAD for enhancing lesion detection and breast classification. Materials & Methods: A deep learning enhanced cancer detection model based on a YOLO architecture has been optimized and trained on a large CEM dataset of 1673 patients (7443 images) with biopsy-proven lesions from various hospitals and acquisition systems. The evaluation was conducted using metrics derived from the free receiver operating characteristic (FROC) for the lesion detection and the receiver operating characteristic (ROC) to evaluate the overall breast classification performance. The performances were evaluated for different types of image input and for each patient background parenchymal enhancement (BPE) level. Results: The optimized model achieved an area under the curve (AUROC) of 0.964 for breast classification. Using both low-energy and recombined image as inputs for the DL model shows greater performance than using only the recombined image. For the lesion detection, the model was able to detect 90% of all cancers with a false positive (non-cancer) rate of 0.128 per image. This study demonstrates a high impact of BPE on classification and detection performance. Conclusion: The developed CEM CAD outperforms previously published papers and its performance is comparable to radiologist-reported classification and detection capability. |
format | Online Article Text |
id | pubmed-10451612 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104516122023-08-26 AI-Based Cancer Detection Model for Contrast-Enhanced Mammography Jailin, Clément Mohamed, Sara Iordache, Razvan Milioni De Carvalho, Pablo Ahmed, Salwa Yehia Abdel Sattar, Engy Abdullah Moustafa, Amr Farouk Ibrahim Gomaa, Mohammed Mohammed Kamal, Rashaa Mohammed Vancamberg, Laurence Bioengineering (Basel) Article Background: The recent development of deep neural network models for the analysis of breast images has been a breakthrough in computer-aided diagnostics (CAD). Contrast-enhanced mammography (CEM) is a recent mammography modality providing anatomical and functional imaging of the breast. Despite the clinical benefits it could bring, only a few research studies have been conducted around deep-learning (DL) based CAD for CEM, especially because the access to large databases is still limited. This study presents the development and evaluation of a CEM-CAD for enhancing lesion detection and breast classification. Materials & Methods: A deep learning enhanced cancer detection model based on a YOLO architecture has been optimized and trained on a large CEM dataset of 1673 patients (7443 images) with biopsy-proven lesions from various hospitals and acquisition systems. The evaluation was conducted using metrics derived from the free receiver operating characteristic (FROC) for the lesion detection and the receiver operating characteristic (ROC) to evaluate the overall breast classification performance. The performances were evaluated for different types of image input and for each patient background parenchymal enhancement (BPE) level. Results: The optimized model achieved an area under the curve (AUROC) of 0.964 for breast classification. Using both low-energy and recombined image as inputs for the DL model shows greater performance than using only the recombined image. For the lesion detection, the model was able to detect 90% of all cancers with a false positive (non-cancer) rate of 0.128 per image. This study demonstrates a high impact of BPE on classification and detection performance. Conclusion: The developed CEM CAD outperforms previously published papers and its performance is comparable to radiologist-reported classification and detection capability. MDPI 2023-08-17 /pmc/articles/PMC10451612/ /pubmed/37627859 http://dx.doi.org/10.3390/bioengineering10080974 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jailin, Clément Mohamed, Sara Iordache, Razvan Milioni De Carvalho, Pablo Ahmed, Salwa Yehia Abdel Sattar, Engy Abdullah Moustafa, Amr Farouk Ibrahim Gomaa, Mohammed Mohammed Kamal, Rashaa Mohammed Vancamberg, Laurence AI-Based Cancer Detection Model for Contrast-Enhanced Mammography |
title | AI-Based Cancer Detection Model for Contrast-Enhanced Mammography |
title_full | AI-Based Cancer Detection Model for Contrast-Enhanced Mammography |
title_fullStr | AI-Based Cancer Detection Model for Contrast-Enhanced Mammography |
title_full_unstemmed | AI-Based Cancer Detection Model for Contrast-Enhanced Mammography |
title_short | AI-Based Cancer Detection Model for Contrast-Enhanced Mammography |
title_sort | ai-based cancer detection model for contrast-enhanced mammography |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451612/ https://www.ncbi.nlm.nih.gov/pubmed/37627859 http://dx.doi.org/10.3390/bioengineering10080974 |
work_keys_str_mv | AT jailinclement aibasedcancerdetectionmodelforcontrastenhancedmammography AT mohamedsara aibasedcancerdetectionmodelforcontrastenhancedmammography AT iordacherazvan aibasedcancerdetectionmodelforcontrastenhancedmammography AT milionidecarvalhopablo aibasedcancerdetectionmodelforcontrastenhancedmammography AT ahmedsalwayehia aibasedcancerdetectionmodelforcontrastenhancedmammography AT abdelsattarengyabdullah aibasedcancerdetectionmodelforcontrastenhancedmammography AT moustafaamrfaroukibrahim aibasedcancerdetectionmodelforcontrastenhancedmammography AT gomaamohammedmohammed aibasedcancerdetectionmodelforcontrastenhancedmammography AT kamalrashaamohammed aibasedcancerdetectionmodelforcontrastenhancedmammography AT vancamberglaurence aibasedcancerdetectionmodelforcontrastenhancedmammography |