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A Review on the Impact of Oxidative Stress and Medicinal Plants on Leydig Cells
Leydig cells are essential for steroidogenesis and spermatogenesis. An imbalance in the production of reactive oxygen species (ROS) and the cellular antioxidant level brings about oxidative stress. Oxidative stress (OS) results in the dysfunction of Leydig cells, thereby impairing steroidogenesis, s...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451682/ https://www.ncbi.nlm.nih.gov/pubmed/37627554 http://dx.doi.org/10.3390/antiox12081559 |
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author | Monageng, Elizabeth Offor, Ugochukwu Takalani, Ndivhuho Beauty Mohlala, Kutullo Opuwari, Chinyerum Sylvia |
author_facet | Monageng, Elizabeth Offor, Ugochukwu Takalani, Ndivhuho Beauty Mohlala, Kutullo Opuwari, Chinyerum Sylvia |
author_sort | Monageng, Elizabeth |
collection | PubMed |
description | Leydig cells are essential for steroidogenesis and spermatogenesis. An imbalance in the production of reactive oxygen species (ROS) and the cellular antioxidant level brings about oxidative stress. Oxidative stress (OS) results in the dysfunction of Leydig cells, thereby impairing steroidogenesis, spermatogenesis, and ultimately, male infertility. To prevent Leydig cells from oxidative insults, there needs to be a balance between the ROS production and the cellular protective capacity of antioxidants. Evidence indicates that medicinal plants could improve Leydig cell function at specific concentrations under basal or OS conditions. The increased usage of medicinal plants has been considered a possible alternative treatment for male infertility. This review aims to provide an overview of the impact of oxidative stress on Leydig cells as well as the effects of various medicinal plant extracts on TM3 Leydig cells. The medicinal plants of interest include Aspalathus linearis, Camellia sinensis, Moringa oleifera, Morinda officinale, Taraxacum officinale, Trichilia emetica, Terminalia sambesiaca, Peltophorum africanum, Ximenia caffra, Serenoa repens, Zingiber officinale, Eugenia jambolana, and a combination of dandelion and fermented rooibos (CRS-10). According to the findings obtained from studies conducted on the evaluated medicinal plants, it can, therefore, be concluded that the medicinal plants maintain the antioxidant profile of Leydig cells under basal conditions and have protective or restorative effects following exposure to oxidative stress. The available data suggest that the protective role exhibited by the evaluated plants may be attributed to their antioxidant content. Additionally, the use of the optimal dosage or concentration of the extracts in the management of oxidative stress is of the utmost importance, and the measurement of their oxidation reduction potential is recommended. |
format | Online Article Text |
id | pubmed-10451682 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104516822023-08-26 A Review on the Impact of Oxidative Stress and Medicinal Plants on Leydig Cells Monageng, Elizabeth Offor, Ugochukwu Takalani, Ndivhuho Beauty Mohlala, Kutullo Opuwari, Chinyerum Sylvia Antioxidants (Basel) Review Leydig cells are essential for steroidogenesis and spermatogenesis. An imbalance in the production of reactive oxygen species (ROS) and the cellular antioxidant level brings about oxidative stress. Oxidative stress (OS) results in the dysfunction of Leydig cells, thereby impairing steroidogenesis, spermatogenesis, and ultimately, male infertility. To prevent Leydig cells from oxidative insults, there needs to be a balance between the ROS production and the cellular protective capacity of antioxidants. Evidence indicates that medicinal plants could improve Leydig cell function at specific concentrations under basal or OS conditions. The increased usage of medicinal plants has been considered a possible alternative treatment for male infertility. This review aims to provide an overview of the impact of oxidative stress on Leydig cells as well as the effects of various medicinal plant extracts on TM3 Leydig cells. The medicinal plants of interest include Aspalathus linearis, Camellia sinensis, Moringa oleifera, Morinda officinale, Taraxacum officinale, Trichilia emetica, Terminalia sambesiaca, Peltophorum africanum, Ximenia caffra, Serenoa repens, Zingiber officinale, Eugenia jambolana, and a combination of dandelion and fermented rooibos (CRS-10). According to the findings obtained from studies conducted on the evaluated medicinal plants, it can, therefore, be concluded that the medicinal plants maintain the antioxidant profile of Leydig cells under basal conditions and have protective or restorative effects following exposure to oxidative stress. The available data suggest that the protective role exhibited by the evaluated plants may be attributed to their antioxidant content. Additionally, the use of the optimal dosage or concentration of the extracts in the management of oxidative stress is of the utmost importance, and the measurement of their oxidation reduction potential is recommended. MDPI 2023-08-04 /pmc/articles/PMC10451682/ /pubmed/37627554 http://dx.doi.org/10.3390/antiox12081559 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Monageng, Elizabeth Offor, Ugochukwu Takalani, Ndivhuho Beauty Mohlala, Kutullo Opuwari, Chinyerum Sylvia A Review on the Impact of Oxidative Stress and Medicinal Plants on Leydig Cells |
title | A Review on the Impact of Oxidative Stress and Medicinal Plants on Leydig Cells |
title_full | A Review on the Impact of Oxidative Stress and Medicinal Plants on Leydig Cells |
title_fullStr | A Review on the Impact of Oxidative Stress and Medicinal Plants on Leydig Cells |
title_full_unstemmed | A Review on the Impact of Oxidative Stress and Medicinal Plants on Leydig Cells |
title_short | A Review on the Impact of Oxidative Stress and Medicinal Plants on Leydig Cells |
title_sort | review on the impact of oxidative stress and medicinal plants on leydig cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451682/ https://www.ncbi.nlm.nih.gov/pubmed/37627554 http://dx.doi.org/10.3390/antiox12081559 |
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