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A Review on the Impact of Oxidative Stress and Medicinal Plants on Leydig Cells

Leydig cells are essential for steroidogenesis and spermatogenesis. An imbalance in the production of reactive oxygen species (ROS) and the cellular antioxidant level brings about oxidative stress. Oxidative stress (OS) results in the dysfunction of Leydig cells, thereby impairing steroidogenesis, s...

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Autores principales: Monageng, Elizabeth, Offor, Ugochukwu, Takalani, Ndivhuho Beauty, Mohlala, Kutullo, Opuwari, Chinyerum Sylvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451682/
https://www.ncbi.nlm.nih.gov/pubmed/37627554
http://dx.doi.org/10.3390/antiox12081559
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author Monageng, Elizabeth
Offor, Ugochukwu
Takalani, Ndivhuho Beauty
Mohlala, Kutullo
Opuwari, Chinyerum Sylvia
author_facet Monageng, Elizabeth
Offor, Ugochukwu
Takalani, Ndivhuho Beauty
Mohlala, Kutullo
Opuwari, Chinyerum Sylvia
author_sort Monageng, Elizabeth
collection PubMed
description Leydig cells are essential for steroidogenesis and spermatogenesis. An imbalance in the production of reactive oxygen species (ROS) and the cellular antioxidant level brings about oxidative stress. Oxidative stress (OS) results in the dysfunction of Leydig cells, thereby impairing steroidogenesis, spermatogenesis, and ultimately, male infertility. To prevent Leydig cells from oxidative insults, there needs to be a balance between the ROS production and the cellular protective capacity of antioxidants. Evidence indicates that medicinal plants could improve Leydig cell function at specific concentrations under basal or OS conditions. The increased usage of medicinal plants has been considered a possible alternative treatment for male infertility. This review aims to provide an overview of the impact of oxidative stress on Leydig cells as well as the effects of various medicinal plant extracts on TM3 Leydig cells. The medicinal plants of interest include Aspalathus linearis, Camellia sinensis, Moringa oleifera, Morinda officinale, Taraxacum officinale, Trichilia emetica, Terminalia sambesiaca, Peltophorum africanum, Ximenia caffra, Serenoa repens, Zingiber officinale, Eugenia jambolana, and a combination of dandelion and fermented rooibos (CRS-10). According to the findings obtained from studies conducted on the evaluated medicinal plants, it can, therefore, be concluded that the medicinal plants maintain the antioxidant profile of Leydig cells under basal conditions and have protective or restorative effects following exposure to oxidative stress. The available data suggest that the protective role exhibited by the evaluated plants may be attributed to their antioxidant content. Additionally, the use of the optimal dosage or concentration of the extracts in the management of oxidative stress is of the utmost importance, and the measurement of their oxidation reduction potential is recommended.
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spelling pubmed-104516822023-08-26 A Review on the Impact of Oxidative Stress and Medicinal Plants on Leydig Cells Monageng, Elizabeth Offor, Ugochukwu Takalani, Ndivhuho Beauty Mohlala, Kutullo Opuwari, Chinyerum Sylvia Antioxidants (Basel) Review Leydig cells are essential for steroidogenesis and spermatogenesis. An imbalance in the production of reactive oxygen species (ROS) and the cellular antioxidant level brings about oxidative stress. Oxidative stress (OS) results in the dysfunction of Leydig cells, thereby impairing steroidogenesis, spermatogenesis, and ultimately, male infertility. To prevent Leydig cells from oxidative insults, there needs to be a balance between the ROS production and the cellular protective capacity of antioxidants. Evidence indicates that medicinal plants could improve Leydig cell function at specific concentrations under basal or OS conditions. The increased usage of medicinal plants has been considered a possible alternative treatment for male infertility. This review aims to provide an overview of the impact of oxidative stress on Leydig cells as well as the effects of various medicinal plant extracts on TM3 Leydig cells. The medicinal plants of interest include Aspalathus linearis, Camellia sinensis, Moringa oleifera, Morinda officinale, Taraxacum officinale, Trichilia emetica, Terminalia sambesiaca, Peltophorum africanum, Ximenia caffra, Serenoa repens, Zingiber officinale, Eugenia jambolana, and a combination of dandelion and fermented rooibos (CRS-10). According to the findings obtained from studies conducted on the evaluated medicinal plants, it can, therefore, be concluded that the medicinal plants maintain the antioxidant profile of Leydig cells under basal conditions and have protective or restorative effects following exposure to oxidative stress. The available data suggest that the protective role exhibited by the evaluated plants may be attributed to their antioxidant content. Additionally, the use of the optimal dosage or concentration of the extracts in the management of oxidative stress is of the utmost importance, and the measurement of their oxidation reduction potential is recommended. MDPI 2023-08-04 /pmc/articles/PMC10451682/ /pubmed/37627554 http://dx.doi.org/10.3390/antiox12081559 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Monageng, Elizabeth
Offor, Ugochukwu
Takalani, Ndivhuho Beauty
Mohlala, Kutullo
Opuwari, Chinyerum Sylvia
A Review on the Impact of Oxidative Stress and Medicinal Plants on Leydig Cells
title A Review on the Impact of Oxidative Stress and Medicinal Plants on Leydig Cells
title_full A Review on the Impact of Oxidative Stress and Medicinal Plants on Leydig Cells
title_fullStr A Review on the Impact of Oxidative Stress and Medicinal Plants on Leydig Cells
title_full_unstemmed A Review on the Impact of Oxidative Stress and Medicinal Plants on Leydig Cells
title_short A Review on the Impact of Oxidative Stress and Medicinal Plants on Leydig Cells
title_sort review on the impact of oxidative stress and medicinal plants on leydig cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451682/
https://www.ncbi.nlm.nih.gov/pubmed/37627554
http://dx.doi.org/10.3390/antiox12081559
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