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Advances in Understanding the Role of NRF2 in Liver Pathophysiology and Its Relationship with Hepatic-Specific Cyclooxygenase-2 Expression

Oxidative stress and inflammation play an important role in the pathophysiological changes of liver diseases. Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that positively regulates the basal and inducible expression of a large battery of cytoprotective genes, thus pla...

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Autores principales: Fuertes-Agudo, Marina, Luque-Tévar, María, Cucarella, Carme, Martín-Sanz, Paloma, Casado, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451723/
https://www.ncbi.nlm.nih.gov/pubmed/37627486
http://dx.doi.org/10.3390/antiox12081491
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author Fuertes-Agudo, Marina
Luque-Tévar, María
Cucarella, Carme
Martín-Sanz, Paloma
Casado, Marta
author_facet Fuertes-Agudo, Marina
Luque-Tévar, María
Cucarella, Carme
Martín-Sanz, Paloma
Casado, Marta
author_sort Fuertes-Agudo, Marina
collection PubMed
description Oxidative stress and inflammation play an important role in the pathophysiological changes of liver diseases. Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that positively regulates the basal and inducible expression of a large battery of cytoprotective genes, thus playing a key role in protecting against oxidative damage. Cyclooxygenase-2 (COX-2) is a key enzyme in prostaglandin biosynthesis. Its expression has always been associated with the induction of inflammation, but we have shown that, in addition to possessing other benefits, the constitutive expression of COX-2 in hepatocytes is beneficial in reducing inflammation and oxidative stress in multiple liver diseases. In this review, we summarized the role of NRF2 as a main agent in the resolution of oxidative stress, the crucial role of NRF2 signaling pathways during the development of chronic liver diseases, and, finally we related its action to that of COX-2, where it appears to operate as its partner in providing a hepatoprotective effect.
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spelling pubmed-104517232023-08-26 Advances in Understanding the Role of NRF2 in Liver Pathophysiology and Its Relationship with Hepatic-Specific Cyclooxygenase-2 Expression Fuertes-Agudo, Marina Luque-Tévar, María Cucarella, Carme Martín-Sanz, Paloma Casado, Marta Antioxidants (Basel) Review Oxidative stress and inflammation play an important role in the pathophysiological changes of liver diseases. Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that positively regulates the basal and inducible expression of a large battery of cytoprotective genes, thus playing a key role in protecting against oxidative damage. Cyclooxygenase-2 (COX-2) is a key enzyme in prostaglandin biosynthesis. Its expression has always been associated with the induction of inflammation, but we have shown that, in addition to possessing other benefits, the constitutive expression of COX-2 in hepatocytes is beneficial in reducing inflammation and oxidative stress in multiple liver diseases. In this review, we summarized the role of NRF2 as a main agent in the resolution of oxidative stress, the crucial role of NRF2 signaling pathways during the development of chronic liver diseases, and, finally we related its action to that of COX-2, where it appears to operate as its partner in providing a hepatoprotective effect. MDPI 2023-07-26 /pmc/articles/PMC10451723/ /pubmed/37627486 http://dx.doi.org/10.3390/antiox12081491 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fuertes-Agudo, Marina
Luque-Tévar, María
Cucarella, Carme
Martín-Sanz, Paloma
Casado, Marta
Advances in Understanding the Role of NRF2 in Liver Pathophysiology and Its Relationship with Hepatic-Specific Cyclooxygenase-2 Expression
title Advances in Understanding the Role of NRF2 in Liver Pathophysiology and Its Relationship with Hepatic-Specific Cyclooxygenase-2 Expression
title_full Advances in Understanding the Role of NRF2 in Liver Pathophysiology and Its Relationship with Hepatic-Specific Cyclooxygenase-2 Expression
title_fullStr Advances in Understanding the Role of NRF2 in Liver Pathophysiology and Its Relationship with Hepatic-Specific Cyclooxygenase-2 Expression
title_full_unstemmed Advances in Understanding the Role of NRF2 in Liver Pathophysiology and Its Relationship with Hepatic-Specific Cyclooxygenase-2 Expression
title_short Advances in Understanding the Role of NRF2 in Liver Pathophysiology and Its Relationship with Hepatic-Specific Cyclooxygenase-2 Expression
title_sort advances in understanding the role of nrf2 in liver pathophysiology and its relationship with hepatic-specific cyclooxygenase-2 expression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451723/
https://www.ncbi.nlm.nih.gov/pubmed/37627486
http://dx.doi.org/10.3390/antiox12081491
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