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Updated Review on Clinically-Relevant Properties of Delafloxacin

The extensive use of fluoroquinolones has been consequently accompanied by the emergence of bacterial resistance, which triggers the necessity to discover new compounds. Delafloxacin is a brand-new anionic non-zwitterionic fluoroquinolone with some structural particularities that give it attractive...

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Autores principales: Turban, Adrien, Guérin, François, Dinh, Aurélien, Cattoir, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451745/
https://www.ncbi.nlm.nih.gov/pubmed/37627661
http://dx.doi.org/10.3390/antibiotics12081241
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author Turban, Adrien
Guérin, François
Dinh, Aurélien
Cattoir, Vincent
author_facet Turban, Adrien
Guérin, François
Dinh, Aurélien
Cattoir, Vincent
author_sort Turban, Adrien
collection PubMed
description The extensive use of fluoroquinolones has been consequently accompanied by the emergence of bacterial resistance, which triggers the necessity to discover new compounds. Delafloxacin is a brand-new anionic non-zwitterionic fluoroquinolone with some structural particularities that give it attractive proprieties: high activity under acidic conditions, greater in vitro activity against Gram-positive bacteria—even those showing resistance to currently-used fluoroquinolones—and nearly equivalent affinity for both type-II topoisomerases (i.e., DNA gyrase and topoisomerase IV). During phases II and III clinical trials, delafloxacin showed non-inferiority compared to standard-of-care therapy in the treatment of acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia, which resulted in its approval in 2017 by the Food and Drug Administration for indications. Thanks to its overall good tolerance, its broad-spectrum in vitro activity, and its ease of use, it could represent a promising molecule for the treatment of bacterial infections.
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spelling pubmed-104517452023-08-26 Updated Review on Clinically-Relevant Properties of Delafloxacin Turban, Adrien Guérin, François Dinh, Aurélien Cattoir, Vincent Antibiotics (Basel) Review The extensive use of fluoroquinolones has been consequently accompanied by the emergence of bacterial resistance, which triggers the necessity to discover new compounds. Delafloxacin is a brand-new anionic non-zwitterionic fluoroquinolone with some structural particularities that give it attractive proprieties: high activity under acidic conditions, greater in vitro activity against Gram-positive bacteria—even those showing resistance to currently-used fluoroquinolones—and nearly equivalent affinity for both type-II topoisomerases (i.e., DNA gyrase and topoisomerase IV). During phases II and III clinical trials, delafloxacin showed non-inferiority compared to standard-of-care therapy in the treatment of acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia, which resulted in its approval in 2017 by the Food and Drug Administration for indications. Thanks to its overall good tolerance, its broad-spectrum in vitro activity, and its ease of use, it could represent a promising molecule for the treatment of bacterial infections. MDPI 2023-07-28 /pmc/articles/PMC10451745/ /pubmed/37627661 http://dx.doi.org/10.3390/antibiotics12081241 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Turban, Adrien
Guérin, François
Dinh, Aurélien
Cattoir, Vincent
Updated Review on Clinically-Relevant Properties of Delafloxacin
title Updated Review on Clinically-Relevant Properties of Delafloxacin
title_full Updated Review on Clinically-Relevant Properties of Delafloxacin
title_fullStr Updated Review on Clinically-Relevant Properties of Delafloxacin
title_full_unstemmed Updated Review on Clinically-Relevant Properties of Delafloxacin
title_short Updated Review on Clinically-Relevant Properties of Delafloxacin
title_sort updated review on clinically-relevant properties of delafloxacin
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451745/
https://www.ncbi.nlm.nih.gov/pubmed/37627661
http://dx.doi.org/10.3390/antibiotics12081241
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