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The Role of Lifestyle and Dietary Factors in the Development of Premature Ovarian Insufficiency

Premature ovarian insufficiency (POI) is a condition that arises from dysfunction or early depletion of the ovarian follicle pool accompanied by an earlier-than-normal loss of fertility in young women. Oxidative stress has been suggested as an important factor in the decline of fertility in women an...

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Autores principales: Shelling, Andrew N., Ahmed Nasef, Noha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451748/
https://www.ncbi.nlm.nih.gov/pubmed/37627595
http://dx.doi.org/10.3390/antiox12081601
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author Shelling, Andrew N.
Ahmed Nasef, Noha
author_facet Shelling, Andrew N.
Ahmed Nasef, Noha
author_sort Shelling, Andrew N.
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description Premature ovarian insufficiency (POI) is a condition that arises from dysfunction or early depletion of the ovarian follicle pool accompanied by an earlier-than-normal loss of fertility in young women. Oxidative stress has been suggested as an important factor in the decline of fertility in women and POI. In this review, we discuss the mechanisms of oxidative stress implicated in ovarian ageing and dysfunction in relation to POI, in particular mitochondrial dysfunction, apoptosis and inflammation. Genetic defects, autoimmunity and chemotherapy, are some of the reviewed hallmarks of POI that can lead to increased oxidative stress. Additionally, we highlight lifestyle factors, including diet, low energy availability and BMI, that can increase the risk of POI. The final section of this review discusses dietary factors associated with POI, including consumption of oily fish, mitochondria nutrient therapy, melatonin, dairy and vitamins that can be targeted as potential interventions, especially for at-risk women and in combination with personalised nutrition. Understanding the impact of lifestyle and its implications for POI and oxidative stress holds great promise in reducing the burden of this condition.
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spelling pubmed-104517482023-08-26 The Role of Lifestyle and Dietary Factors in the Development of Premature Ovarian Insufficiency Shelling, Andrew N. Ahmed Nasef, Noha Antioxidants (Basel) Review Premature ovarian insufficiency (POI) is a condition that arises from dysfunction or early depletion of the ovarian follicle pool accompanied by an earlier-than-normal loss of fertility in young women. Oxidative stress has been suggested as an important factor in the decline of fertility in women and POI. In this review, we discuss the mechanisms of oxidative stress implicated in ovarian ageing and dysfunction in relation to POI, in particular mitochondrial dysfunction, apoptosis and inflammation. Genetic defects, autoimmunity and chemotherapy, are some of the reviewed hallmarks of POI that can lead to increased oxidative stress. Additionally, we highlight lifestyle factors, including diet, low energy availability and BMI, that can increase the risk of POI. The final section of this review discusses dietary factors associated with POI, including consumption of oily fish, mitochondria nutrient therapy, melatonin, dairy and vitamins that can be targeted as potential interventions, especially for at-risk women and in combination with personalised nutrition. Understanding the impact of lifestyle and its implications for POI and oxidative stress holds great promise in reducing the burden of this condition. MDPI 2023-08-11 /pmc/articles/PMC10451748/ /pubmed/37627595 http://dx.doi.org/10.3390/antiox12081601 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shelling, Andrew N.
Ahmed Nasef, Noha
The Role of Lifestyle and Dietary Factors in the Development of Premature Ovarian Insufficiency
title The Role of Lifestyle and Dietary Factors in the Development of Premature Ovarian Insufficiency
title_full The Role of Lifestyle and Dietary Factors in the Development of Premature Ovarian Insufficiency
title_fullStr The Role of Lifestyle and Dietary Factors in the Development of Premature Ovarian Insufficiency
title_full_unstemmed The Role of Lifestyle and Dietary Factors in the Development of Premature Ovarian Insufficiency
title_short The Role of Lifestyle and Dietary Factors in the Development of Premature Ovarian Insufficiency
title_sort role of lifestyle and dietary factors in the development of premature ovarian insufficiency
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451748/
https://www.ncbi.nlm.nih.gov/pubmed/37627595
http://dx.doi.org/10.3390/antiox12081601
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