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Vascular Dysfunctions Contribute to the Long-Term Cognitive Deficits Following COVID-19

SIMPLE SUMMARY: Although SARS-CoV-2 primarily affects the upper respiratory system and the lungs, it can also affect vasculature, leading to the impairment of endothelial and multi-organ function. SARS-CoV-2 can trigger the release of pro-inflammatory cytokines, leading to disruption of tight juncti...

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Autores principales: Shabani, Zahra, Liu, Jialing, Su, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451811/
https://www.ncbi.nlm.nih.gov/pubmed/37626992
http://dx.doi.org/10.3390/biology12081106
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author Shabani, Zahra
Liu, Jialing
Su, Hua
author_facet Shabani, Zahra
Liu, Jialing
Su, Hua
author_sort Shabani, Zahra
collection PubMed
description SIMPLE SUMMARY: Although SARS-CoV-2 primarily affects the upper respiratory system and the lungs, it can also affect vasculature, leading to the impairment of endothelial and multi-organ function. SARS-CoV-2 can trigger the release of pro-inflammatory cytokines, leading to disruption of tight junction proteins between endothelial cells and impairment of the blood-brain barrier (BBB). This process further allows the infiltration of immune cells and other particles into the brain, worsening brain injury. Prolonged neuro-inflammation and disruption of the BBB have been postulated as the potential primary causes of both acute and chronic cognitive dysfunction in COVID-19 patients. This review explores the effects of COVID-19 on vascular dysfunction and consequent cognitive impairment in patients. ABSTRACT: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a single-stranded RNA virus and a member of the corona virus family, primarily affecting the upper respiratory system and the lungs. Like many other respiratory viruses, SARS-CoV-2 can spread to other organ systems. Apart from causing diarrhea, another very common but debilitating complication caused by SARS-CoV-2 is neurological symptoms and cognitive difficulties, which occur in up to two thirds of hospitalized COVID-19 patients and range from shortness of concentration and overall declined cognitive speed to executive or memory function impairment. Neuro-cognitive dysfunction and “brain fog” are frequently present in COVID-19 cases, which can last several months after the infection, leading to disruption of daily life. Cumulative evidence suggests that SARS-CoV-2 affects vasculature in the extra-pulmonary systems directly or indirectly, leading to impairment of endothelial function and even multi-organ damage. The post COVID-19 long-lasting neurocognitive impairments have not been studied fully and their underlying mechanism remains elusive. In this review, we summarize the current understanding of the effects of COVID-19 on vascular dysfunction and how vascular dysfunction leads to cognitive impairment in patients.
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spelling pubmed-104518112023-08-26 Vascular Dysfunctions Contribute to the Long-Term Cognitive Deficits Following COVID-19 Shabani, Zahra Liu, Jialing Su, Hua Biology (Basel) Review SIMPLE SUMMARY: Although SARS-CoV-2 primarily affects the upper respiratory system and the lungs, it can also affect vasculature, leading to the impairment of endothelial and multi-organ function. SARS-CoV-2 can trigger the release of pro-inflammatory cytokines, leading to disruption of tight junction proteins between endothelial cells and impairment of the blood-brain barrier (BBB). This process further allows the infiltration of immune cells and other particles into the brain, worsening brain injury. Prolonged neuro-inflammation and disruption of the BBB have been postulated as the potential primary causes of both acute and chronic cognitive dysfunction in COVID-19 patients. This review explores the effects of COVID-19 on vascular dysfunction and consequent cognitive impairment in patients. ABSTRACT: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a single-stranded RNA virus and a member of the corona virus family, primarily affecting the upper respiratory system and the lungs. Like many other respiratory viruses, SARS-CoV-2 can spread to other organ systems. Apart from causing diarrhea, another very common but debilitating complication caused by SARS-CoV-2 is neurological symptoms and cognitive difficulties, which occur in up to two thirds of hospitalized COVID-19 patients and range from shortness of concentration and overall declined cognitive speed to executive or memory function impairment. Neuro-cognitive dysfunction and “brain fog” are frequently present in COVID-19 cases, which can last several months after the infection, leading to disruption of daily life. Cumulative evidence suggests that SARS-CoV-2 affects vasculature in the extra-pulmonary systems directly or indirectly, leading to impairment of endothelial function and even multi-organ damage. The post COVID-19 long-lasting neurocognitive impairments have not been studied fully and their underlying mechanism remains elusive. In this review, we summarize the current understanding of the effects of COVID-19 on vascular dysfunction and how vascular dysfunction leads to cognitive impairment in patients. MDPI 2023-08-09 /pmc/articles/PMC10451811/ /pubmed/37626992 http://dx.doi.org/10.3390/biology12081106 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shabani, Zahra
Liu, Jialing
Su, Hua
Vascular Dysfunctions Contribute to the Long-Term Cognitive Deficits Following COVID-19
title Vascular Dysfunctions Contribute to the Long-Term Cognitive Deficits Following COVID-19
title_full Vascular Dysfunctions Contribute to the Long-Term Cognitive Deficits Following COVID-19
title_fullStr Vascular Dysfunctions Contribute to the Long-Term Cognitive Deficits Following COVID-19
title_full_unstemmed Vascular Dysfunctions Contribute to the Long-Term Cognitive Deficits Following COVID-19
title_short Vascular Dysfunctions Contribute to the Long-Term Cognitive Deficits Following COVID-19
title_sort vascular dysfunctions contribute to the long-term cognitive deficits following covid-19
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451811/
https://www.ncbi.nlm.nih.gov/pubmed/37626992
http://dx.doi.org/10.3390/biology12081106
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