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Molecular Interactions between Neuroglobin and Cytochrome c: Possible Mechanisms of Antiapoptotic Defense in Neuronal Cells

Neuroglobin, which is a heme protein from the globin family that is predominantly expressed in nervous tissue, can promote a neuronal survivor. However, the molecular mechanisms underlying the neuroprotective function of Ngb remain poorly understood to this day. The interactions between neuroglobin...

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Autores principales: Semenova, Marina A., Chertkova, Rita V., Kirpichnikov, Mikhail P., Dolgikh, Dmitry A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452090/
https://www.ncbi.nlm.nih.gov/pubmed/37627298
http://dx.doi.org/10.3390/biom13081233
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author Semenova, Marina A.
Chertkova, Rita V.
Kirpichnikov, Mikhail P.
Dolgikh, Dmitry A.
author_facet Semenova, Marina A.
Chertkova, Rita V.
Kirpichnikov, Mikhail P.
Dolgikh, Dmitry A.
author_sort Semenova, Marina A.
collection PubMed
description Neuroglobin, which is a heme protein from the globin family that is predominantly expressed in nervous tissue, can promote a neuronal survivor. However, the molecular mechanisms underlying the neuroprotective function of Ngb remain poorly understood to this day. The interactions between neuroglobin and mitochondrial cytochrome c may serve as at least one of the mechanisms of neuroglobin-mediated neuroprotection. Interestingly, neuroglobin and cytochrome c possibly can interact with or without electron transfer both in the cytoplasm and within the mitochondria. This review provides a general picture of molecular interactions between neuroglobin and cytochrome c based on the recent experimental and computational work on neuroglobin and cytochrome c interactions.
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spelling pubmed-104520902023-08-26 Molecular Interactions between Neuroglobin and Cytochrome c: Possible Mechanisms of Antiapoptotic Defense in Neuronal Cells Semenova, Marina A. Chertkova, Rita V. Kirpichnikov, Mikhail P. Dolgikh, Dmitry A. Biomolecules Review Neuroglobin, which is a heme protein from the globin family that is predominantly expressed in nervous tissue, can promote a neuronal survivor. However, the molecular mechanisms underlying the neuroprotective function of Ngb remain poorly understood to this day. The interactions between neuroglobin and mitochondrial cytochrome c may serve as at least one of the mechanisms of neuroglobin-mediated neuroprotection. Interestingly, neuroglobin and cytochrome c possibly can interact with or without electron transfer both in the cytoplasm and within the mitochondria. This review provides a general picture of molecular interactions between neuroglobin and cytochrome c based on the recent experimental and computational work on neuroglobin and cytochrome c interactions. MDPI 2023-08-10 /pmc/articles/PMC10452090/ /pubmed/37627298 http://dx.doi.org/10.3390/biom13081233 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Semenova, Marina A.
Chertkova, Rita V.
Kirpichnikov, Mikhail P.
Dolgikh, Dmitry A.
Molecular Interactions between Neuroglobin and Cytochrome c: Possible Mechanisms of Antiapoptotic Defense in Neuronal Cells
title Molecular Interactions between Neuroglobin and Cytochrome c: Possible Mechanisms of Antiapoptotic Defense in Neuronal Cells
title_full Molecular Interactions between Neuroglobin and Cytochrome c: Possible Mechanisms of Antiapoptotic Defense in Neuronal Cells
title_fullStr Molecular Interactions between Neuroglobin and Cytochrome c: Possible Mechanisms of Antiapoptotic Defense in Neuronal Cells
title_full_unstemmed Molecular Interactions between Neuroglobin and Cytochrome c: Possible Mechanisms of Antiapoptotic Defense in Neuronal Cells
title_short Molecular Interactions between Neuroglobin and Cytochrome c: Possible Mechanisms of Antiapoptotic Defense in Neuronal Cells
title_sort molecular interactions between neuroglobin and cytochrome c: possible mechanisms of antiapoptotic defense in neuronal cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452090/
https://www.ncbi.nlm.nih.gov/pubmed/37627298
http://dx.doi.org/10.3390/biom13081233
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