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Chronic Hepatitis B Infection: New Approaches towards Cure

Chronic hepatitis B virus (HBV) infection leads to the development of cirrhosis and hepatocellular carcinoma. Lifelong treatment with nucleotides/nucleoside antiviral agents is effective at suppressing HBV replication, however, adherence to daily therapy can be challenging. This review discusses rec...

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Detalles Bibliográficos
Autores principales: Ogunnaike, Mojisola, Das, Srijanee, Raut, Samiksha S., Sultana, Ashrafi, Nayan, Mohammad Ullah, Ganesan, Murali, Edagwa, Benson J., Osna, Natalia A., Poluektova, Larisa Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452112/
https://www.ncbi.nlm.nih.gov/pubmed/37627273
http://dx.doi.org/10.3390/biom13081208
Descripción
Sumario:Chronic hepatitis B virus (HBV) infection leads to the development of cirrhosis and hepatocellular carcinoma. Lifelong treatment with nucleotides/nucleoside antiviral agents is effective at suppressing HBV replication, however, adherence to daily therapy can be challenging. This review discusses recent advances in the development of long-acting formulations for HBV treatment and prevention, which could potentially improve adherence. Promising new compounds that target distinct steps of the virus life cycle are summarized. In addition to treatments that suppress viral replication, curative strategies are focused on the elimination of covalently closed circular DNA and the inactivation of the integrated viral DNA from infected hepatocytes. We highlight promising long-acting antivirals and genome editing strategies for the elimination or deactivation of persistent viral DNA products in development.