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Oxidative Stress in Healthy and Pathological Red Blood Cells
Red cell diseases encompass a group of inherited or acquired erythrocyte disorders that affect the structure, function, or production of red blood cells (RBCs). These disorders can lead to various clinical manifestations, including anemia, hemolysis, inflammation, and impaired oxygen-carrying capaci...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452114/ https://www.ncbi.nlm.nih.gov/pubmed/37627327 http://dx.doi.org/10.3390/biom13081262 |
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author | Orrico, Florencia Laurance, Sandrine Lopez, Ana C. Lefevre, Sophie D. Thomson, Leonor Möller, Matias N. Ostuni, Mariano A. |
author_facet | Orrico, Florencia Laurance, Sandrine Lopez, Ana C. Lefevre, Sophie D. Thomson, Leonor Möller, Matias N. Ostuni, Mariano A. |
author_sort | Orrico, Florencia |
collection | PubMed |
description | Red cell diseases encompass a group of inherited or acquired erythrocyte disorders that affect the structure, function, or production of red blood cells (RBCs). These disorders can lead to various clinical manifestations, including anemia, hemolysis, inflammation, and impaired oxygen-carrying capacity. Oxidative stress, characterized by an imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense mechanisms, plays a significant role in the pathophysiology of red cell diseases. In this review, we discuss the most relevant oxidant species involved in RBC damage, the enzymatic and low molecular weight antioxidant systems that protect RBCs against oxidative injury, and finally, the role of oxidative stress in different red cell diseases, including sickle cell disease, glucose 6-phosphate dehydrogenase deficiency, and pyruvate kinase deficiency, highlighting the underlying mechanisms leading to pathological RBC phenotypes. |
format | Online Article Text |
id | pubmed-10452114 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104521142023-08-26 Oxidative Stress in Healthy and Pathological Red Blood Cells Orrico, Florencia Laurance, Sandrine Lopez, Ana C. Lefevre, Sophie D. Thomson, Leonor Möller, Matias N. Ostuni, Mariano A. Biomolecules Review Red cell diseases encompass a group of inherited or acquired erythrocyte disorders that affect the structure, function, or production of red blood cells (RBCs). These disorders can lead to various clinical manifestations, including anemia, hemolysis, inflammation, and impaired oxygen-carrying capacity. Oxidative stress, characterized by an imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense mechanisms, plays a significant role in the pathophysiology of red cell diseases. In this review, we discuss the most relevant oxidant species involved in RBC damage, the enzymatic and low molecular weight antioxidant systems that protect RBCs against oxidative injury, and finally, the role of oxidative stress in different red cell diseases, including sickle cell disease, glucose 6-phosphate dehydrogenase deficiency, and pyruvate kinase deficiency, highlighting the underlying mechanisms leading to pathological RBC phenotypes. MDPI 2023-08-18 /pmc/articles/PMC10452114/ /pubmed/37627327 http://dx.doi.org/10.3390/biom13081262 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Orrico, Florencia Laurance, Sandrine Lopez, Ana C. Lefevre, Sophie D. Thomson, Leonor Möller, Matias N. Ostuni, Mariano A. Oxidative Stress in Healthy and Pathological Red Blood Cells |
title | Oxidative Stress in Healthy and Pathological Red Blood Cells |
title_full | Oxidative Stress in Healthy and Pathological Red Blood Cells |
title_fullStr | Oxidative Stress in Healthy and Pathological Red Blood Cells |
title_full_unstemmed | Oxidative Stress in Healthy and Pathological Red Blood Cells |
title_short | Oxidative Stress in Healthy and Pathological Red Blood Cells |
title_sort | oxidative stress in healthy and pathological red blood cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452114/ https://www.ncbi.nlm.nih.gov/pubmed/37627327 http://dx.doi.org/10.3390/biom13081262 |
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