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Differences in the EEG Power Spectrum and Cross-Frequency Coupling Patterns between Young and Elderly Patients during Sevoflurane Anesthesia

Electroencephalography (EEG) is widely used for monitoring the depth of anesthesia in surgical patients. Distinguishing age-related EEG features under general anesthesia will help to optimize anesthetic depth monitoring during surgery for elderly patients. This retrospective cohort study included 41...

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Autores principales: Zhang, Xinxin, Li, Ao, Wang, Sa, Wang, Tingting, Liu, Tiantian, Wang, Yonghui, Fu, Jingwen, Zhao, Guangchao, Yang, Qianzi, Dong, Hailong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452117/
https://www.ncbi.nlm.nih.gov/pubmed/37626505
http://dx.doi.org/10.3390/brainsci13081149
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author Zhang, Xinxin
Li, Ao
Wang, Sa
Wang, Tingting
Liu, Tiantian
Wang, Yonghui
Fu, Jingwen
Zhao, Guangchao
Yang, Qianzi
Dong, Hailong
author_facet Zhang, Xinxin
Li, Ao
Wang, Sa
Wang, Tingting
Liu, Tiantian
Wang, Yonghui
Fu, Jingwen
Zhao, Guangchao
Yang, Qianzi
Dong, Hailong
author_sort Zhang, Xinxin
collection PubMed
description Electroencephalography (EEG) is widely used for monitoring the depth of anesthesia in surgical patients. Distinguishing age-related EEG features under general anesthesia will help to optimize anesthetic depth monitoring during surgery for elderly patients. This retrospective cohort study included 41 patients aged from 18 to 79 years undergoing noncardiac surgery under general anesthesia. We compared the power spectral signatures and phase–amplitude coupling patterns of the young and elderly groups under baseline and surgical anesthetic depth. General anesthesia by sevoflurane significantly increased the spectral power of delta, theta, alpha, and beta bands and strengthened the cross-frequency coupling both in young and elderly patients. However, the variation in EEG power spectral density and the modulation of alpha amplitudes on delta phases was relatively weaker in elderly patients. In conclusion, the EEG under general anesthesia using sevoflurane exhibited similar dynamic features between young and elderly patients, and the weakened alteration of spectral power and cross-frequency coupling patterns could be utilized to precisely quantify the depth of anesthesia in elderly patients.
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spelling pubmed-104521172023-08-26 Differences in the EEG Power Spectrum and Cross-Frequency Coupling Patterns between Young and Elderly Patients during Sevoflurane Anesthesia Zhang, Xinxin Li, Ao Wang, Sa Wang, Tingting Liu, Tiantian Wang, Yonghui Fu, Jingwen Zhao, Guangchao Yang, Qianzi Dong, Hailong Brain Sci Article Electroencephalography (EEG) is widely used for monitoring the depth of anesthesia in surgical patients. Distinguishing age-related EEG features under general anesthesia will help to optimize anesthetic depth monitoring during surgery for elderly patients. This retrospective cohort study included 41 patients aged from 18 to 79 years undergoing noncardiac surgery under general anesthesia. We compared the power spectral signatures and phase–amplitude coupling patterns of the young and elderly groups under baseline and surgical anesthetic depth. General anesthesia by sevoflurane significantly increased the spectral power of delta, theta, alpha, and beta bands and strengthened the cross-frequency coupling both in young and elderly patients. However, the variation in EEG power spectral density and the modulation of alpha amplitudes on delta phases was relatively weaker in elderly patients. In conclusion, the EEG under general anesthesia using sevoflurane exhibited similar dynamic features between young and elderly patients, and the weakened alteration of spectral power and cross-frequency coupling patterns could be utilized to precisely quantify the depth of anesthesia in elderly patients. MDPI 2023-07-31 /pmc/articles/PMC10452117/ /pubmed/37626505 http://dx.doi.org/10.3390/brainsci13081149 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Xinxin
Li, Ao
Wang, Sa
Wang, Tingting
Liu, Tiantian
Wang, Yonghui
Fu, Jingwen
Zhao, Guangchao
Yang, Qianzi
Dong, Hailong
Differences in the EEG Power Spectrum and Cross-Frequency Coupling Patterns between Young and Elderly Patients during Sevoflurane Anesthesia
title Differences in the EEG Power Spectrum and Cross-Frequency Coupling Patterns between Young and Elderly Patients during Sevoflurane Anesthesia
title_full Differences in the EEG Power Spectrum and Cross-Frequency Coupling Patterns between Young and Elderly Patients during Sevoflurane Anesthesia
title_fullStr Differences in the EEG Power Spectrum and Cross-Frequency Coupling Patterns between Young and Elderly Patients during Sevoflurane Anesthesia
title_full_unstemmed Differences in the EEG Power Spectrum and Cross-Frequency Coupling Patterns between Young and Elderly Patients during Sevoflurane Anesthesia
title_short Differences in the EEG Power Spectrum and Cross-Frequency Coupling Patterns between Young and Elderly Patients during Sevoflurane Anesthesia
title_sort differences in the eeg power spectrum and cross-frequency coupling patterns between young and elderly patients during sevoflurane anesthesia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452117/
https://www.ncbi.nlm.nih.gov/pubmed/37626505
http://dx.doi.org/10.3390/brainsci13081149
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