Cargando…

Recent Advances in DNA Nanotechnology-Enabled Biosensors for Virus Detection

Virus-related infectious diseases are serious threats to humans, which makes virus detection of great importance. Traditional virus-detection methods usually suffer from low sensitivity and specificity, are time-consuming, have a high cost, etc. Recently, DNA biosensors based on DNA nanotechnology h...

Descripción completa

Detalles Bibliográficos
Autores principales: Yuwen, Lihui, Zhang, Shifeng, Chao, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452139/
https://www.ncbi.nlm.nih.gov/pubmed/37622908
http://dx.doi.org/10.3390/bios13080822
_version_ 1785095594111401984
author Yuwen, Lihui
Zhang, Shifeng
Chao, Jie
author_facet Yuwen, Lihui
Zhang, Shifeng
Chao, Jie
author_sort Yuwen, Lihui
collection PubMed
description Virus-related infectious diseases are serious threats to humans, which makes virus detection of great importance. Traditional virus-detection methods usually suffer from low sensitivity and specificity, are time-consuming, have a high cost, etc. Recently, DNA biosensors based on DNA nanotechnology have shown great potential in virus detection. DNA nanotechnology, specifically DNA tiles and DNA aptamers, has achieved atomic precision in nanostructure construction. Exploiting the programmable nature of DNA nanostructures, researchers have developed DNA nanobiosensors that outperform traditional virus-detection methods. This paper reviews the history of DNA tiles and DNA aptamers, and it briefly describes the Baltimore classification of virology. Moreover, the advance of virus detection by using DNA nanobiosensors is discussed in detail and compared with traditional virus-detection methods. Finally, challenges faced by DNA nanobiosensors in virus detection are summarized, and a perspective on the future development of DNA nanobiosensors in virus detection is also provided.
format Online
Article
Text
id pubmed-10452139
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104521392023-08-26 Recent Advances in DNA Nanotechnology-Enabled Biosensors for Virus Detection Yuwen, Lihui Zhang, Shifeng Chao, Jie Biosensors (Basel) Review Virus-related infectious diseases are serious threats to humans, which makes virus detection of great importance. Traditional virus-detection methods usually suffer from low sensitivity and specificity, are time-consuming, have a high cost, etc. Recently, DNA biosensors based on DNA nanotechnology have shown great potential in virus detection. DNA nanotechnology, specifically DNA tiles and DNA aptamers, has achieved atomic precision in nanostructure construction. Exploiting the programmable nature of DNA nanostructures, researchers have developed DNA nanobiosensors that outperform traditional virus-detection methods. This paper reviews the history of DNA tiles and DNA aptamers, and it briefly describes the Baltimore classification of virology. Moreover, the advance of virus detection by using DNA nanobiosensors is discussed in detail and compared with traditional virus-detection methods. Finally, challenges faced by DNA nanobiosensors in virus detection are summarized, and a perspective on the future development of DNA nanobiosensors in virus detection is also provided. MDPI 2023-08-15 /pmc/articles/PMC10452139/ /pubmed/37622908 http://dx.doi.org/10.3390/bios13080822 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yuwen, Lihui
Zhang, Shifeng
Chao, Jie
Recent Advances in DNA Nanotechnology-Enabled Biosensors for Virus Detection
title Recent Advances in DNA Nanotechnology-Enabled Biosensors for Virus Detection
title_full Recent Advances in DNA Nanotechnology-Enabled Biosensors for Virus Detection
title_fullStr Recent Advances in DNA Nanotechnology-Enabled Biosensors for Virus Detection
title_full_unstemmed Recent Advances in DNA Nanotechnology-Enabled Biosensors for Virus Detection
title_short Recent Advances in DNA Nanotechnology-Enabled Biosensors for Virus Detection
title_sort recent advances in dna nanotechnology-enabled biosensors for virus detection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452139/
https://www.ncbi.nlm.nih.gov/pubmed/37622908
http://dx.doi.org/10.3390/bios13080822
work_keys_str_mv AT yuwenlihui recentadvancesindnananotechnologyenabledbiosensorsforvirusdetection
AT zhangshifeng recentadvancesindnananotechnologyenabledbiosensorsforvirusdetection
AT chaojie recentadvancesindnananotechnologyenabledbiosensorsforvirusdetection