Cargando…
Porcine Models of Spinal Cord Injury
Large animal models of spinal cord injury may be useful tools in facilitating the development of translational therapies for spinal cord injury (SCI). Porcine models of SCI are of particular interest due to significant anatomic and physiologic similarities to humans. The similar size and functional...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452184/ https://www.ncbi.nlm.nih.gov/pubmed/37626699 http://dx.doi.org/10.3390/biomedicines11082202 |
_version_ | 1785095605627912192 |
---|---|
author | Wathen, Connor A. Ghenbot, Yohannes G. Ozturk, Ali K. Cullen, D. Kacy O’Donnell, John C. Petrov, Dmitriy |
author_facet | Wathen, Connor A. Ghenbot, Yohannes G. Ozturk, Ali K. Cullen, D. Kacy O’Donnell, John C. Petrov, Dmitriy |
author_sort | Wathen, Connor A. |
collection | PubMed |
description | Large animal models of spinal cord injury may be useful tools in facilitating the development of translational therapies for spinal cord injury (SCI). Porcine models of SCI are of particular interest due to significant anatomic and physiologic similarities to humans. The similar size and functional organization of the porcine spinal cord, for instance, may facilitate more accurate evaluation of axonal regeneration across long distances that more closely resemble the realities of clinical SCI. Furthermore, the porcine cardiovascular system closely resembles that of humans, including at the level of the spinal cord vascular supply. These anatomic and physiologic similarities to humans not only enable more representative SCI models with the ability to accurately evaluate the translational potential of novel therapies, especially biologics, they also facilitate the collection of physiologic data to assess response to therapy in a setting similar to those used in the clinical management of SCI. This review summarizes the current landscape of porcine spinal cord injury research, including the available models, outcome measures, and the strengths, limitations, and alternatives to porcine models. As the number of investigational SCI therapies grow, porcine SCI models provide an attractive platform for the evaluation of promising treatments prior to clinical translation. |
format | Online Article Text |
id | pubmed-10452184 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104521842023-08-26 Porcine Models of Spinal Cord Injury Wathen, Connor A. Ghenbot, Yohannes G. Ozturk, Ali K. Cullen, D. Kacy O’Donnell, John C. Petrov, Dmitriy Biomedicines Review Large animal models of spinal cord injury may be useful tools in facilitating the development of translational therapies for spinal cord injury (SCI). Porcine models of SCI are of particular interest due to significant anatomic and physiologic similarities to humans. The similar size and functional organization of the porcine spinal cord, for instance, may facilitate more accurate evaluation of axonal regeneration across long distances that more closely resemble the realities of clinical SCI. Furthermore, the porcine cardiovascular system closely resembles that of humans, including at the level of the spinal cord vascular supply. These anatomic and physiologic similarities to humans not only enable more representative SCI models with the ability to accurately evaluate the translational potential of novel therapies, especially biologics, they also facilitate the collection of physiologic data to assess response to therapy in a setting similar to those used in the clinical management of SCI. This review summarizes the current landscape of porcine spinal cord injury research, including the available models, outcome measures, and the strengths, limitations, and alternatives to porcine models. As the number of investigational SCI therapies grow, porcine SCI models provide an attractive platform for the evaluation of promising treatments prior to clinical translation. MDPI 2023-08-04 /pmc/articles/PMC10452184/ /pubmed/37626699 http://dx.doi.org/10.3390/biomedicines11082202 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wathen, Connor A. Ghenbot, Yohannes G. Ozturk, Ali K. Cullen, D. Kacy O’Donnell, John C. Petrov, Dmitriy Porcine Models of Spinal Cord Injury |
title | Porcine Models of Spinal Cord Injury |
title_full | Porcine Models of Spinal Cord Injury |
title_fullStr | Porcine Models of Spinal Cord Injury |
title_full_unstemmed | Porcine Models of Spinal Cord Injury |
title_short | Porcine Models of Spinal Cord Injury |
title_sort | porcine models of spinal cord injury |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452184/ https://www.ncbi.nlm.nih.gov/pubmed/37626699 http://dx.doi.org/10.3390/biomedicines11082202 |
work_keys_str_mv | AT wathenconnora porcinemodelsofspinalcordinjury AT ghenbotyohannesg porcinemodelsofspinalcordinjury AT ozturkalik porcinemodelsofspinalcordinjury AT cullendkacy porcinemodelsofspinalcordinjury AT odonnelljohnc porcinemodelsofspinalcordinjury AT petrovdmitriy porcinemodelsofspinalcordinjury |