Functional Recovery after the Application of Amniotic Tissues and Methylene Blue during Radical Prostatectomy—A Pilot Study

Amniotic tissues and methylene blue (MB) provide the ability for neuroregeneration, and MB enables intraoperative neurostaining. We first combined the techniques to explore a neuroprotective effect on early functional outcomes in a retrospective proof-of-concept trial of 14 patients undergoing radic...

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Autores principales: Barski, Dimitri, Tsaur, Igor, Boros, Mihaly, Brune, Jan, Otto, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452294/
https://www.ncbi.nlm.nih.gov/pubmed/37626756
http://dx.doi.org/10.3390/biomedicines11082260
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author Barski, Dimitri
Tsaur, Igor
Boros, Mihaly
Brune, Jan
Otto, Thomas
author_facet Barski, Dimitri
Tsaur, Igor
Boros, Mihaly
Brune, Jan
Otto, Thomas
author_sort Barski, Dimitri
collection PubMed
description Amniotic tissues and methylene blue (MB) provide the ability for neuroregeneration, and MB enables intraoperative neurostaining. We first combined the techniques to explore a neuroprotective effect on early functional outcomes in a retrospective proof-of-concept trial of 14 patients undergoing radical prostatectomy (RP). The patients were followed up at a median of 13 months, and the continence and potency rates were reported. Early recovery of continence was found after three months. No effect on potency was detected. The findings indicate the feasibility of this tissue-engineering strategy, and justify prospective comparative studies.
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spelling pubmed-104522942023-08-26 Functional Recovery after the Application of Amniotic Tissues and Methylene Blue during Radical Prostatectomy—A Pilot Study Barski, Dimitri Tsaur, Igor Boros, Mihaly Brune, Jan Otto, Thomas Biomedicines Article Amniotic tissues and methylene blue (MB) provide the ability for neuroregeneration, and MB enables intraoperative neurostaining. We first combined the techniques to explore a neuroprotective effect on early functional outcomes in a retrospective proof-of-concept trial of 14 patients undergoing radical prostatectomy (RP). The patients were followed up at a median of 13 months, and the continence and potency rates were reported. Early recovery of continence was found after three months. No effect on potency was detected. The findings indicate the feasibility of this tissue-engineering strategy, and justify prospective comparative studies. MDPI 2023-08-13 /pmc/articles/PMC10452294/ /pubmed/37626756 http://dx.doi.org/10.3390/biomedicines11082260 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Barski, Dimitri
Tsaur, Igor
Boros, Mihaly
Brune, Jan
Otto, Thomas
Functional Recovery after the Application of Amniotic Tissues and Methylene Blue during Radical Prostatectomy—A Pilot Study
title Functional Recovery after the Application of Amniotic Tissues and Methylene Blue during Radical Prostatectomy—A Pilot Study
title_full Functional Recovery after the Application of Amniotic Tissues and Methylene Blue during Radical Prostatectomy—A Pilot Study
title_fullStr Functional Recovery after the Application of Amniotic Tissues and Methylene Blue during Radical Prostatectomy—A Pilot Study
title_full_unstemmed Functional Recovery after the Application of Amniotic Tissues and Methylene Blue during Radical Prostatectomy—A Pilot Study
title_short Functional Recovery after the Application of Amniotic Tissues and Methylene Blue during Radical Prostatectomy—A Pilot Study
title_sort functional recovery after the application of amniotic tissues and methylene blue during radical prostatectomy—a pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452294/
https://www.ncbi.nlm.nih.gov/pubmed/37626756
http://dx.doi.org/10.3390/biomedicines11082260
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