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Recent Advances in Microbiota-Associated Metabolites in Heart Failure

Heart failure is a risk factor for adverse events such as sudden cardiac arrest, liver and kidney failure and death. The gut microbiota and its metabolites are directly linked to the pathogenesis of heart failure. As emerging studies have increased in the literature on the role of specific gut micro...

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Autores principales: Masenga, Sepiso K., Povia, Joreen P., Lwiindi, Propheria C., Kirabo, Annet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452327/
https://www.ncbi.nlm.nih.gov/pubmed/37626809
http://dx.doi.org/10.3390/biomedicines11082313
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author Masenga, Sepiso K.
Povia, Joreen P.
Lwiindi, Propheria C.
Kirabo, Annet
author_facet Masenga, Sepiso K.
Povia, Joreen P.
Lwiindi, Propheria C.
Kirabo, Annet
author_sort Masenga, Sepiso K.
collection PubMed
description Heart failure is a risk factor for adverse events such as sudden cardiac arrest, liver and kidney failure and death. The gut microbiota and its metabolites are directly linked to the pathogenesis of heart failure. As emerging studies have increased in the literature on the role of specific gut microbiota metabolites in heart failure development, this review highlights and summarizes the current evidence and underlying mechanisms associated with the pathogenesis of heart failure. We found that gut microbiota-derived metabolites such as short chain fatty acids, bile acids, branched-chain amino acids, tryptophan and indole derivatives as well as trimethylamine-derived metabolite, trimethylamine N-oxide, play critical roles in promoting heart failure through various mechanisms. Mainly, they modulate complex signaling pathways such as nuclear factor kappa-light-chain-enhancer of activated B cells, Bcl-2 interacting protein 3, NLR Family Pyrin Domain Containing inflammasome, and Protein kinase RNA-like endoplasmic reticulum kinase. We have also highlighted the beneficial role of other gut metabolites in heart failure and other cardiovascular and metabolic diseases.
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spelling pubmed-104523272023-08-26 Recent Advances in Microbiota-Associated Metabolites in Heart Failure Masenga, Sepiso K. Povia, Joreen P. Lwiindi, Propheria C. Kirabo, Annet Biomedicines Review Heart failure is a risk factor for adverse events such as sudden cardiac arrest, liver and kidney failure and death. The gut microbiota and its metabolites are directly linked to the pathogenesis of heart failure. As emerging studies have increased in the literature on the role of specific gut microbiota metabolites in heart failure development, this review highlights and summarizes the current evidence and underlying mechanisms associated with the pathogenesis of heart failure. We found that gut microbiota-derived metabolites such as short chain fatty acids, bile acids, branched-chain amino acids, tryptophan and indole derivatives as well as trimethylamine-derived metabolite, trimethylamine N-oxide, play critical roles in promoting heart failure through various mechanisms. Mainly, they modulate complex signaling pathways such as nuclear factor kappa-light-chain-enhancer of activated B cells, Bcl-2 interacting protein 3, NLR Family Pyrin Domain Containing inflammasome, and Protein kinase RNA-like endoplasmic reticulum kinase. We have also highlighted the beneficial role of other gut metabolites in heart failure and other cardiovascular and metabolic diseases. MDPI 2023-08-21 /pmc/articles/PMC10452327/ /pubmed/37626809 http://dx.doi.org/10.3390/biomedicines11082313 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Masenga, Sepiso K.
Povia, Joreen P.
Lwiindi, Propheria C.
Kirabo, Annet
Recent Advances in Microbiota-Associated Metabolites in Heart Failure
title Recent Advances in Microbiota-Associated Metabolites in Heart Failure
title_full Recent Advances in Microbiota-Associated Metabolites in Heart Failure
title_fullStr Recent Advances in Microbiota-Associated Metabolites in Heart Failure
title_full_unstemmed Recent Advances in Microbiota-Associated Metabolites in Heart Failure
title_short Recent Advances in Microbiota-Associated Metabolites in Heart Failure
title_sort recent advances in microbiota-associated metabolites in heart failure
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452327/
https://www.ncbi.nlm.nih.gov/pubmed/37626809
http://dx.doi.org/10.3390/biomedicines11082313
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