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Recent Advances in Microbiota-Associated Metabolites in Heart Failure
Heart failure is a risk factor for adverse events such as sudden cardiac arrest, liver and kidney failure and death. The gut microbiota and its metabolites are directly linked to the pathogenesis of heart failure. As emerging studies have increased in the literature on the role of specific gut micro...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452327/ https://www.ncbi.nlm.nih.gov/pubmed/37626809 http://dx.doi.org/10.3390/biomedicines11082313 |
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author | Masenga, Sepiso K. Povia, Joreen P. Lwiindi, Propheria C. Kirabo, Annet |
author_facet | Masenga, Sepiso K. Povia, Joreen P. Lwiindi, Propheria C. Kirabo, Annet |
author_sort | Masenga, Sepiso K. |
collection | PubMed |
description | Heart failure is a risk factor for adverse events such as sudden cardiac arrest, liver and kidney failure and death. The gut microbiota and its metabolites are directly linked to the pathogenesis of heart failure. As emerging studies have increased in the literature on the role of specific gut microbiota metabolites in heart failure development, this review highlights and summarizes the current evidence and underlying mechanisms associated with the pathogenesis of heart failure. We found that gut microbiota-derived metabolites such as short chain fatty acids, bile acids, branched-chain amino acids, tryptophan and indole derivatives as well as trimethylamine-derived metabolite, trimethylamine N-oxide, play critical roles in promoting heart failure through various mechanisms. Mainly, they modulate complex signaling pathways such as nuclear factor kappa-light-chain-enhancer of activated B cells, Bcl-2 interacting protein 3, NLR Family Pyrin Domain Containing inflammasome, and Protein kinase RNA-like endoplasmic reticulum kinase. We have also highlighted the beneficial role of other gut metabolites in heart failure and other cardiovascular and metabolic diseases. |
format | Online Article Text |
id | pubmed-10452327 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104523272023-08-26 Recent Advances in Microbiota-Associated Metabolites in Heart Failure Masenga, Sepiso K. Povia, Joreen P. Lwiindi, Propheria C. Kirabo, Annet Biomedicines Review Heart failure is a risk factor for adverse events such as sudden cardiac arrest, liver and kidney failure and death. The gut microbiota and its metabolites are directly linked to the pathogenesis of heart failure. As emerging studies have increased in the literature on the role of specific gut microbiota metabolites in heart failure development, this review highlights and summarizes the current evidence and underlying mechanisms associated with the pathogenesis of heart failure. We found that gut microbiota-derived metabolites such as short chain fatty acids, bile acids, branched-chain amino acids, tryptophan and indole derivatives as well as trimethylamine-derived metabolite, trimethylamine N-oxide, play critical roles in promoting heart failure through various mechanisms. Mainly, they modulate complex signaling pathways such as nuclear factor kappa-light-chain-enhancer of activated B cells, Bcl-2 interacting protein 3, NLR Family Pyrin Domain Containing inflammasome, and Protein kinase RNA-like endoplasmic reticulum kinase. We have also highlighted the beneficial role of other gut metabolites in heart failure and other cardiovascular and metabolic diseases. MDPI 2023-08-21 /pmc/articles/PMC10452327/ /pubmed/37626809 http://dx.doi.org/10.3390/biomedicines11082313 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Masenga, Sepiso K. Povia, Joreen P. Lwiindi, Propheria C. Kirabo, Annet Recent Advances in Microbiota-Associated Metabolites in Heart Failure |
title | Recent Advances in Microbiota-Associated Metabolites in Heart Failure |
title_full | Recent Advances in Microbiota-Associated Metabolites in Heart Failure |
title_fullStr | Recent Advances in Microbiota-Associated Metabolites in Heart Failure |
title_full_unstemmed | Recent Advances in Microbiota-Associated Metabolites in Heart Failure |
title_short | Recent Advances in Microbiota-Associated Metabolites in Heart Failure |
title_sort | recent advances in microbiota-associated metabolites in heart failure |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452327/ https://www.ncbi.nlm.nih.gov/pubmed/37626809 http://dx.doi.org/10.3390/biomedicines11082313 |
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