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New Series of Zaxinone Mimics (MiZax) for Fundamental and Applied Research

The apocarotenoid zaxinone is a recently discovered regulatory metabolite required for proper rice growth and development. In addition, zaxinone and its two mimics (MiZax3 and MiZax5) were shown to have a remarkable growth-promoting activity on crops and a capability to reduce infestation by the roo...

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Autores principales: Jamil, Muhammad, Lin, Pei-Yu, Berqdar, Lamis, Wang, Jian You, Takahashi, Ikuo, Ota, Tsuyoshi, Alhammad, Noor, Chen, Guan-Ting Erica, Asami, Tadao, Al-Babili, Salim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452442/
https://www.ncbi.nlm.nih.gov/pubmed/37627271
http://dx.doi.org/10.3390/biom13081206
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author Jamil, Muhammad
Lin, Pei-Yu
Berqdar, Lamis
Wang, Jian You
Takahashi, Ikuo
Ota, Tsuyoshi
Alhammad, Noor
Chen, Guan-Ting Erica
Asami, Tadao
Al-Babili, Salim
author_facet Jamil, Muhammad
Lin, Pei-Yu
Berqdar, Lamis
Wang, Jian You
Takahashi, Ikuo
Ota, Tsuyoshi
Alhammad, Noor
Chen, Guan-Ting Erica
Asami, Tadao
Al-Babili, Salim
author_sort Jamil, Muhammad
collection PubMed
description The apocarotenoid zaxinone is a recently discovered regulatory metabolite required for proper rice growth and development. In addition, zaxinone and its two mimics (MiZax3 and MiZax5) were shown to have a remarkable growth-promoting activity on crops and a capability to reduce infestation by the root parasitic plant Striga through decreasing strigolactone (SL) production, suggesting their potential for application in agriculture and horticulture. In the present study, we developed a new series of MiZax via structural modification of the two potent zaxinone mimics (MiZax3 and MiZax5) and evaluated their effect on plant growth and Striga infestation. In general, the structural modifications to MiZax3 and MiZax5 did not additionally improve their overall performance but caused an increase in certain activities. In conclusion, MiZax5 and especially MiZax3 remain the likely most efficient zaxinone mimics for controlling Striga infestation.
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spelling pubmed-104524422023-08-26 New Series of Zaxinone Mimics (MiZax) for Fundamental and Applied Research Jamil, Muhammad Lin, Pei-Yu Berqdar, Lamis Wang, Jian You Takahashi, Ikuo Ota, Tsuyoshi Alhammad, Noor Chen, Guan-Ting Erica Asami, Tadao Al-Babili, Salim Biomolecules Article The apocarotenoid zaxinone is a recently discovered regulatory metabolite required for proper rice growth and development. In addition, zaxinone and its two mimics (MiZax3 and MiZax5) were shown to have a remarkable growth-promoting activity on crops and a capability to reduce infestation by the root parasitic plant Striga through decreasing strigolactone (SL) production, suggesting their potential for application in agriculture and horticulture. In the present study, we developed a new series of MiZax via structural modification of the two potent zaxinone mimics (MiZax3 and MiZax5) and evaluated their effect on plant growth and Striga infestation. In general, the structural modifications to MiZax3 and MiZax5 did not additionally improve their overall performance but caused an increase in certain activities. In conclusion, MiZax5 and especially MiZax3 remain the likely most efficient zaxinone mimics for controlling Striga infestation. MDPI 2023-08-01 /pmc/articles/PMC10452442/ /pubmed/37627271 http://dx.doi.org/10.3390/biom13081206 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jamil, Muhammad
Lin, Pei-Yu
Berqdar, Lamis
Wang, Jian You
Takahashi, Ikuo
Ota, Tsuyoshi
Alhammad, Noor
Chen, Guan-Ting Erica
Asami, Tadao
Al-Babili, Salim
New Series of Zaxinone Mimics (MiZax) for Fundamental and Applied Research
title New Series of Zaxinone Mimics (MiZax) for Fundamental and Applied Research
title_full New Series of Zaxinone Mimics (MiZax) for Fundamental and Applied Research
title_fullStr New Series of Zaxinone Mimics (MiZax) for Fundamental and Applied Research
title_full_unstemmed New Series of Zaxinone Mimics (MiZax) for Fundamental and Applied Research
title_short New Series of Zaxinone Mimics (MiZax) for Fundamental and Applied Research
title_sort new series of zaxinone mimics (mizax) for fundamental and applied research
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452442/
https://www.ncbi.nlm.nih.gov/pubmed/37627271
http://dx.doi.org/10.3390/biom13081206
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