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Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street
Cancer predisposition syndromes are entities determined especially by germinal pathogenic variants, with most of them autosomal dominantly inherited. The risk of a form of cancer is variable throughout life and affects various organs, including the thyroid. Knowing the heterogeneous clinical picture...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452453/ https://www.ncbi.nlm.nih.gov/pubmed/37626640 http://dx.doi.org/10.3390/biomedicines11082143 |
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author | Balinisteanu, Ioana Panzaru, Monica-Cristina Caba, Lavinia Ungureanu, Maria-Christina Florea, Andreea Grigore, Ana Maria Gorduza, Eusebiu Vlad |
author_facet | Balinisteanu, Ioana Panzaru, Monica-Cristina Caba, Lavinia Ungureanu, Maria-Christina Florea, Andreea Grigore, Ana Maria Gorduza, Eusebiu Vlad |
author_sort | Balinisteanu, Ioana |
collection | PubMed |
description | Cancer predisposition syndromes are entities determined especially by germinal pathogenic variants, with most of them autosomal dominantly inherited. The risk of a form of cancer is variable throughout life and affects various organs, including the thyroid. Knowing the heterogeneous clinical picture and the existing genotype–phenotype correlations in some forms of thyroid cancer associated with these syndromes is important for adequate and early management of patients and families. This review synthesizes the current knowledge on genes and proteins involved in cancer predisposition syndromes with thyroid cancer and the phenomena of heterogeneity (locus, allelic, mutational, and clinical). |
format | Online Article Text |
id | pubmed-10452453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104524532023-08-26 Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street Balinisteanu, Ioana Panzaru, Monica-Cristina Caba, Lavinia Ungureanu, Maria-Christina Florea, Andreea Grigore, Ana Maria Gorduza, Eusebiu Vlad Biomedicines Review Cancer predisposition syndromes are entities determined especially by germinal pathogenic variants, with most of them autosomal dominantly inherited. The risk of a form of cancer is variable throughout life and affects various organs, including the thyroid. Knowing the heterogeneous clinical picture and the existing genotype–phenotype correlations in some forms of thyroid cancer associated with these syndromes is important for adequate and early management of patients and families. This review synthesizes the current knowledge on genes and proteins involved in cancer predisposition syndromes with thyroid cancer and the phenomena of heterogeneity (locus, allelic, mutational, and clinical). MDPI 2023-07-29 /pmc/articles/PMC10452453/ /pubmed/37626640 http://dx.doi.org/10.3390/biomedicines11082143 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Balinisteanu, Ioana Panzaru, Monica-Cristina Caba, Lavinia Ungureanu, Maria-Christina Florea, Andreea Grigore, Ana Maria Gorduza, Eusebiu Vlad Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street |
title | Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street |
title_full | Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street |
title_fullStr | Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street |
title_full_unstemmed | Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street |
title_short | Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street |
title_sort | cancer predisposition syndromes and thyroid cancer: keys for a short two-way street |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452453/ https://www.ncbi.nlm.nih.gov/pubmed/37626640 http://dx.doi.org/10.3390/biomedicines11082143 |
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