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Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street

Cancer predisposition syndromes are entities determined especially by germinal pathogenic variants, with most of them autosomal dominantly inherited. The risk of a form of cancer is variable throughout life and affects various organs, including the thyroid. Knowing the heterogeneous clinical picture...

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Autores principales: Balinisteanu, Ioana, Panzaru, Monica-Cristina, Caba, Lavinia, Ungureanu, Maria-Christina, Florea, Andreea, Grigore, Ana Maria, Gorduza, Eusebiu Vlad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452453/
https://www.ncbi.nlm.nih.gov/pubmed/37626640
http://dx.doi.org/10.3390/biomedicines11082143
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author Balinisteanu, Ioana
Panzaru, Monica-Cristina
Caba, Lavinia
Ungureanu, Maria-Christina
Florea, Andreea
Grigore, Ana Maria
Gorduza, Eusebiu Vlad
author_facet Balinisteanu, Ioana
Panzaru, Monica-Cristina
Caba, Lavinia
Ungureanu, Maria-Christina
Florea, Andreea
Grigore, Ana Maria
Gorduza, Eusebiu Vlad
author_sort Balinisteanu, Ioana
collection PubMed
description Cancer predisposition syndromes are entities determined especially by germinal pathogenic variants, with most of them autosomal dominantly inherited. The risk of a form of cancer is variable throughout life and affects various organs, including the thyroid. Knowing the heterogeneous clinical picture and the existing genotype–phenotype correlations in some forms of thyroid cancer associated with these syndromes is important for adequate and early management of patients and families. This review synthesizes the current knowledge on genes and proteins involved in cancer predisposition syndromes with thyroid cancer and the phenomena of heterogeneity (locus, allelic, mutational, and clinical).
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spelling pubmed-104524532023-08-26 Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street Balinisteanu, Ioana Panzaru, Monica-Cristina Caba, Lavinia Ungureanu, Maria-Christina Florea, Andreea Grigore, Ana Maria Gorduza, Eusebiu Vlad Biomedicines Review Cancer predisposition syndromes are entities determined especially by germinal pathogenic variants, with most of them autosomal dominantly inherited. The risk of a form of cancer is variable throughout life and affects various organs, including the thyroid. Knowing the heterogeneous clinical picture and the existing genotype–phenotype correlations in some forms of thyroid cancer associated with these syndromes is important for adequate and early management of patients and families. This review synthesizes the current knowledge on genes and proteins involved in cancer predisposition syndromes with thyroid cancer and the phenomena of heterogeneity (locus, allelic, mutational, and clinical). MDPI 2023-07-29 /pmc/articles/PMC10452453/ /pubmed/37626640 http://dx.doi.org/10.3390/biomedicines11082143 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Balinisteanu, Ioana
Panzaru, Monica-Cristina
Caba, Lavinia
Ungureanu, Maria-Christina
Florea, Andreea
Grigore, Ana Maria
Gorduza, Eusebiu Vlad
Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street
title Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street
title_full Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street
title_fullStr Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street
title_full_unstemmed Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street
title_short Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street
title_sort cancer predisposition syndromes and thyroid cancer: keys for a short two-way street
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452453/
https://www.ncbi.nlm.nih.gov/pubmed/37626640
http://dx.doi.org/10.3390/biomedicines11082143
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