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Micro- and Macrovascular Effects of Inflammation in Peripheral Artery Disease—Pathophysiology and Translational Therapeutic Approaches
Inflammation has a critical role in the development and progression of atherosclerosis. On the molecular level, inflammatory pathways negatively impact endothelial barrier properties and thus, tissue homeostasis. Conformational changes and destruction of the glycocalyx further promote pro-inflammato...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452462/ https://www.ncbi.nlm.nih.gov/pubmed/37626780 http://dx.doi.org/10.3390/biomedicines11082284 |
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author | Poledniczek, Michael Neumayer, Christoph Kopp, Christoph W. Schlager, Oliver Gremmel, Thomas Jozkowicz, Alicja Gschwandtner, Michael E. Koppensteiner, Renate Wadowski, Patricia P. |
author_facet | Poledniczek, Michael Neumayer, Christoph Kopp, Christoph W. Schlager, Oliver Gremmel, Thomas Jozkowicz, Alicja Gschwandtner, Michael E. Koppensteiner, Renate Wadowski, Patricia P. |
author_sort | Poledniczek, Michael |
collection | PubMed |
description | Inflammation has a critical role in the development and progression of atherosclerosis. On the molecular level, inflammatory pathways negatively impact endothelial barrier properties and thus, tissue homeostasis. Conformational changes and destruction of the glycocalyx further promote pro-inflammatory pathways also contributing to pro-coagulability and a prothrombotic state. In addition, changes in the extracellular matrix composition lead to (peri-)vascular remodelling and alterations of the vessel wall, e.g., aneurysm formation. Moreover, progressive fibrosis leads to reduced tissue perfusion due to loss of functional capillaries. The present review aims at discussing the molecular and clinical effects of inflammatory processes on the micro- and macrovasculature with a focus on peripheral artery disease. |
format | Online Article Text |
id | pubmed-10452462 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104524622023-08-26 Micro- and Macrovascular Effects of Inflammation in Peripheral Artery Disease—Pathophysiology and Translational Therapeutic Approaches Poledniczek, Michael Neumayer, Christoph Kopp, Christoph W. Schlager, Oliver Gremmel, Thomas Jozkowicz, Alicja Gschwandtner, Michael E. Koppensteiner, Renate Wadowski, Patricia P. Biomedicines Review Inflammation has a critical role in the development and progression of atherosclerosis. On the molecular level, inflammatory pathways negatively impact endothelial barrier properties and thus, tissue homeostasis. Conformational changes and destruction of the glycocalyx further promote pro-inflammatory pathways also contributing to pro-coagulability and a prothrombotic state. In addition, changes in the extracellular matrix composition lead to (peri-)vascular remodelling and alterations of the vessel wall, e.g., aneurysm formation. Moreover, progressive fibrosis leads to reduced tissue perfusion due to loss of functional capillaries. The present review aims at discussing the molecular and clinical effects of inflammatory processes on the micro- and macrovasculature with a focus on peripheral artery disease. MDPI 2023-08-17 /pmc/articles/PMC10452462/ /pubmed/37626780 http://dx.doi.org/10.3390/biomedicines11082284 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Poledniczek, Michael Neumayer, Christoph Kopp, Christoph W. Schlager, Oliver Gremmel, Thomas Jozkowicz, Alicja Gschwandtner, Michael E. Koppensteiner, Renate Wadowski, Patricia P. Micro- and Macrovascular Effects of Inflammation in Peripheral Artery Disease—Pathophysiology and Translational Therapeutic Approaches |
title | Micro- and Macrovascular Effects of Inflammation in Peripheral Artery Disease—Pathophysiology and Translational Therapeutic Approaches |
title_full | Micro- and Macrovascular Effects of Inflammation in Peripheral Artery Disease—Pathophysiology and Translational Therapeutic Approaches |
title_fullStr | Micro- and Macrovascular Effects of Inflammation in Peripheral Artery Disease—Pathophysiology and Translational Therapeutic Approaches |
title_full_unstemmed | Micro- and Macrovascular Effects of Inflammation in Peripheral Artery Disease—Pathophysiology and Translational Therapeutic Approaches |
title_short | Micro- and Macrovascular Effects of Inflammation in Peripheral Artery Disease—Pathophysiology and Translational Therapeutic Approaches |
title_sort | micro- and macrovascular effects of inflammation in peripheral artery disease—pathophysiology and translational therapeutic approaches |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452462/ https://www.ncbi.nlm.nih.gov/pubmed/37626780 http://dx.doi.org/10.3390/biomedicines11082284 |
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