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Micro- and Macrovascular Effects of Inflammation in Peripheral Artery Disease—Pathophysiology and Translational Therapeutic Approaches

Inflammation has a critical role in the development and progression of atherosclerosis. On the molecular level, inflammatory pathways negatively impact endothelial barrier properties and thus, tissue homeostasis. Conformational changes and destruction of the glycocalyx further promote pro-inflammato...

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Autores principales: Poledniczek, Michael, Neumayer, Christoph, Kopp, Christoph W., Schlager, Oliver, Gremmel, Thomas, Jozkowicz, Alicja, Gschwandtner, Michael E., Koppensteiner, Renate, Wadowski, Patricia P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452462/
https://www.ncbi.nlm.nih.gov/pubmed/37626780
http://dx.doi.org/10.3390/biomedicines11082284
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author Poledniczek, Michael
Neumayer, Christoph
Kopp, Christoph W.
Schlager, Oliver
Gremmel, Thomas
Jozkowicz, Alicja
Gschwandtner, Michael E.
Koppensteiner, Renate
Wadowski, Patricia P.
author_facet Poledniczek, Michael
Neumayer, Christoph
Kopp, Christoph W.
Schlager, Oliver
Gremmel, Thomas
Jozkowicz, Alicja
Gschwandtner, Michael E.
Koppensteiner, Renate
Wadowski, Patricia P.
author_sort Poledniczek, Michael
collection PubMed
description Inflammation has a critical role in the development and progression of atherosclerosis. On the molecular level, inflammatory pathways negatively impact endothelial barrier properties and thus, tissue homeostasis. Conformational changes and destruction of the glycocalyx further promote pro-inflammatory pathways also contributing to pro-coagulability and a prothrombotic state. In addition, changes in the extracellular matrix composition lead to (peri-)vascular remodelling and alterations of the vessel wall, e.g., aneurysm formation. Moreover, progressive fibrosis leads to reduced tissue perfusion due to loss of functional capillaries. The present review aims at discussing the molecular and clinical effects of inflammatory processes on the micro- and macrovasculature with a focus on peripheral artery disease.
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spelling pubmed-104524622023-08-26 Micro- and Macrovascular Effects of Inflammation in Peripheral Artery Disease—Pathophysiology and Translational Therapeutic Approaches Poledniczek, Michael Neumayer, Christoph Kopp, Christoph W. Schlager, Oliver Gremmel, Thomas Jozkowicz, Alicja Gschwandtner, Michael E. Koppensteiner, Renate Wadowski, Patricia P. Biomedicines Review Inflammation has a critical role in the development and progression of atherosclerosis. On the molecular level, inflammatory pathways negatively impact endothelial barrier properties and thus, tissue homeostasis. Conformational changes and destruction of the glycocalyx further promote pro-inflammatory pathways also contributing to pro-coagulability and a prothrombotic state. In addition, changes in the extracellular matrix composition lead to (peri-)vascular remodelling and alterations of the vessel wall, e.g., aneurysm formation. Moreover, progressive fibrosis leads to reduced tissue perfusion due to loss of functional capillaries. The present review aims at discussing the molecular and clinical effects of inflammatory processes on the micro- and macrovasculature with a focus on peripheral artery disease. MDPI 2023-08-17 /pmc/articles/PMC10452462/ /pubmed/37626780 http://dx.doi.org/10.3390/biomedicines11082284 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Poledniczek, Michael
Neumayer, Christoph
Kopp, Christoph W.
Schlager, Oliver
Gremmel, Thomas
Jozkowicz, Alicja
Gschwandtner, Michael E.
Koppensteiner, Renate
Wadowski, Patricia P.
Micro- and Macrovascular Effects of Inflammation in Peripheral Artery Disease—Pathophysiology and Translational Therapeutic Approaches
title Micro- and Macrovascular Effects of Inflammation in Peripheral Artery Disease—Pathophysiology and Translational Therapeutic Approaches
title_full Micro- and Macrovascular Effects of Inflammation in Peripheral Artery Disease—Pathophysiology and Translational Therapeutic Approaches
title_fullStr Micro- and Macrovascular Effects of Inflammation in Peripheral Artery Disease—Pathophysiology and Translational Therapeutic Approaches
title_full_unstemmed Micro- and Macrovascular Effects of Inflammation in Peripheral Artery Disease—Pathophysiology and Translational Therapeutic Approaches
title_short Micro- and Macrovascular Effects of Inflammation in Peripheral Artery Disease—Pathophysiology and Translational Therapeutic Approaches
title_sort micro- and macrovascular effects of inflammation in peripheral artery disease—pathophysiology and translational therapeutic approaches
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452462/
https://www.ncbi.nlm.nih.gov/pubmed/37626780
http://dx.doi.org/10.3390/biomedicines11082284
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