Fatty Acid-Activated Proton Transport by Bisaryl Anion Transporters Depolarises Mitochondria and Reduces the Viability of MDA-MB-231 Breast Cancer Cells

In respiring mitochondria, the proton gradient across the inner mitochondrial membrane is used to drive ATP production. Mitochondrial uncouplers, which are typically weak acid protonophores, can disrupt this process to induce mitochondrial dysfunction and apoptosis in cancer cells. We have shown tha...

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Detalles Bibliográficos
Autores principales: York, Edward, McNaughton, Daniel A., Duman, Meryem-Nur, Gale, Philip A., Rawling, Tristan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452527/
https://www.ncbi.nlm.nih.gov/pubmed/37627266
http://dx.doi.org/10.3390/biom13081202

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