IGF/mTORC1/S6 Signaling Is Potentiated and Prolonged by Acute Loading of Subtoxicological Manganese Ion

The insulin-like growth factor (IGF)/insulin signaling (IIS) pathway is involved in cellular responses against intracellular divalent manganese ion (Mn(2+)) accumulation. As a pathway where multiple nodes utilize Mn(2+) as a metallic co-factor, how the IIS signaling patterns are affected by Mn(2+) o...

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Detalles Bibliográficos
Autores principales: Tang, Xueqi, Balachandran, Rekha C., Aschner, Michael, Bowman, Aaron B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452562/
https://www.ncbi.nlm.nih.gov/pubmed/37627294
http://dx.doi.org/10.3390/biom13081229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452562/
https://www.ncbi.nlm.nih.gov/pubmed/37627294
http://dx.doi.org/10.3390/biom13081229

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