Metamorphic Effect of Angiogenic Switch in Tumor Development: Conundrum of Tumor Angiogenesis Toward Progression and Metastatic Potential

Our understanding of angiogenesis has significantly expanded over the past five decades. More recently, research has focused on this process at a more molecular level, looking at it through the signaling pathways that activate it and its non-direct downstream effects. This review discusses current f...

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Detalles Bibliográficos
Autores principales: Moshe, Daniel Leon, Baghaie, Leili, Leroy, Fleur, Skapinker, Elizabeth, Szewczuk, Myron R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452636/
https://www.ncbi.nlm.nih.gov/pubmed/37626639
http://dx.doi.org/10.3390/biomedicines11082142
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author Moshe, Daniel Leon
Baghaie, Leili
Leroy, Fleur
Skapinker, Elizabeth
Szewczuk, Myron R.
author_facet Moshe, Daniel Leon
Baghaie, Leili
Leroy, Fleur
Skapinker, Elizabeth
Szewczuk, Myron R.
author_sort Moshe, Daniel Leon
collection PubMed
description Our understanding of angiogenesis has significantly expanded over the past five decades. More recently, research has focused on this process at a more molecular level, looking at it through the signaling pathways that activate it and its non-direct downstream effects. This review discusses current findings in molecular angiogenesis, focusing on its impact on the immune system. Moreover, the impairment of this process in cancer progression and metastasis is highlighted, and current anti-angiogenic treatments and their effects on tumor growth are discussed.
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spelling pubmed-104526362023-08-26 Metamorphic Effect of Angiogenic Switch in Tumor Development: Conundrum of Tumor Angiogenesis Toward Progression and Metastatic Potential Moshe, Daniel Leon Baghaie, Leili Leroy, Fleur Skapinker, Elizabeth Szewczuk, Myron R. Biomedicines Review Our understanding of angiogenesis has significantly expanded over the past five decades. More recently, research has focused on this process at a more molecular level, looking at it through the signaling pathways that activate it and its non-direct downstream effects. This review discusses current findings in molecular angiogenesis, focusing on its impact on the immune system. Moreover, the impairment of this process in cancer progression and metastasis is highlighted, and current anti-angiogenic treatments and their effects on tumor growth are discussed. MDPI 2023-07-29 /pmc/articles/PMC10452636/ /pubmed/37626639 http://dx.doi.org/10.3390/biomedicines11082142 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Moshe, Daniel Leon
Baghaie, Leili
Leroy, Fleur
Skapinker, Elizabeth
Szewczuk, Myron R.
Metamorphic Effect of Angiogenic Switch in Tumor Development: Conundrum of Tumor Angiogenesis Toward Progression and Metastatic Potential
title Metamorphic Effect of Angiogenic Switch in Tumor Development: Conundrum of Tumor Angiogenesis Toward Progression and Metastatic Potential
title_full Metamorphic Effect of Angiogenic Switch in Tumor Development: Conundrum of Tumor Angiogenesis Toward Progression and Metastatic Potential
title_fullStr Metamorphic Effect of Angiogenic Switch in Tumor Development: Conundrum of Tumor Angiogenesis Toward Progression and Metastatic Potential
title_full_unstemmed Metamorphic Effect of Angiogenic Switch in Tumor Development: Conundrum of Tumor Angiogenesis Toward Progression and Metastatic Potential
title_short Metamorphic Effect of Angiogenic Switch in Tumor Development: Conundrum of Tumor Angiogenesis Toward Progression and Metastatic Potential
title_sort metamorphic effect of angiogenic switch in tumor development: conundrum of tumor angiogenesis toward progression and metastatic potential
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452636/
https://www.ncbi.nlm.nih.gov/pubmed/37626639
http://dx.doi.org/10.3390/biomedicines11082142
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