Cargando…

AMPKα1 Deficiency in Astrocytes from a Rat Model of ALS Is Associated with an Altered Metabolic Resilience

Alterations in the activity of the regulator of cell metabolism AMP-activated protein kinase (AMPK) have been reported in motor neurons from patients and animal models of amyotrophic lateral sclerosis (ALS). Considering the key role played by astrocytes in modulating energy metabolism in the nervous...

Descripción completa

Detalles Bibliográficos
Autores principales:	Belo do Nascimento, Inês, Ates, Gamze, Desmet, Nathalie, Beckers, Pauline, Massie, Ann, Hermans, Emmanuel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452650/ https://www.ncbi.nlm.nih.gov/pubmed/37627248 http://dx.doi.org/10.3390/biom13081183

Ejemplares similares

AMPK Modulates the Metabolic Adaptation of C6 Glioma Cells in Glucose-Deprived Conditions without Affecting Glutamate Transport
por: Belo do Nascimento, Inês, et al.
Publicado: (2022)

Validation of a System x(c)(–) Functional Assay in Cultured Astrocytes and Nervous Tissue Samples
por: Beckers, Pauline, et al.
Publicado: (2022)

Structural investigation of human cystine/glutamate antiporter system x(c) (−) (Sx(c) (−)) using homology modeling and molecular dynamics
por: Hang, Tran Dieu, et al.
Publicado: (2022)

Differential Regulation of Glutamate Transporter Subtypes by Pro-Inflammatory Cytokine TNF-α in Cortical Astrocytes from a Rat Model of Amyotrophic Lateral Sclerosis
por: Dumont, Amélie O., et al.
Publicado: (2014)

Inflammation-associated regulation of RGS in astrocytes and putative implication in neuropathic pain
por: Doyen, Pierre J., et al.
Publicado: (2017)

Lifespan extension with preservation of hippocampal function in aged system x(c)(−)-deficient male mice
por: Verbruggen, Lise, et al.
Publicado: (2022)

AMPK activation protects astrocytes from hypoxia-induced cell death
por: Barialai, Leli, et al.
Publicado: (2020)

Pancreatic acinar cell fate relies on system x(C)(-) to prevent ferroptosis during stress
por: Pan, Zhaolong, et al.
Publicado: (2023)

Curcumin protects from LPS-induced activation of astrocytes via AMPK pathway
por: Cheng, Jing, et al.
Publicado: (2023)

Lack of estrogen receptor α in astrocytes of progranulin-deficient mice
por: DOKE, Mio, et al.
Publicado: (2016)

Barriers to Family Resilience in Caregivers of People Who Have Schizophrenia
por: Fernandes, Júlio Belo, et al.
Publicado: (2021)

Astrocytic β2 Adrenergic Receptor Gene Deletion Affects Memory in Aged Mice
por: Jensen, Cathy Joanna, et al.
Publicado: (2016)

Bupivacaine reduces GlyT1 expression by potentiating the p-AMPKα/BDNF signalling pathway in spinal astrocytes of rats
por: Lu, Kaimei, et al.
Publicado: (2022)

Stimulation of protein synthesis by optogenetic and chemical induction of excitatory synaptic plasticity in hippocampal somatostatin interneurons
por: Honoré, Ève, et al.
Publicado: (2022)

In Vivo Correction of COX Deficiency by Activation of the AMPK/PGC-1α Axis
por: Viscomi, Carlo, et al.
Publicado: (2011)

Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes
por: Komine, Okiru, et al.
Publicado: (2018)

β‐arrestin2 recruitment at the β2 adrenergic receptor: A luciferase complementation assay adapted for undergraduate training in pharmacology
por: Ferraiolo, Mattia, et al.
Publicado: (2021)

Data in support of metabolic reprogramming in transformed mouse cortical astrocytes: A proteomic study
por: Bentaib, Azeddine, et al.
Publicado: (2014)

AMPK Mediates Glucocorticoids Stress-Induced Downregulation of the Glucocorticoid Receptor in Cultured Rat Prefrontal Cortical Astrocytes
por: Yuan, Shi-Ying, et al.
Publicado: (2016)

Astrocyte Elevated Gene-1 Mediates Glycolysis and Tumorigenesis in Colorectal Carcinoma Cells via AMPK Signaling
por: Song, Hong-tao, et al.
Publicado: (2014)

AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival
por: Muraleedharan, Ranjithmenon, et al.
Publicado: (2020)

Astrocytic TGF-β1: detrimental factor in ALS
por: Endo, Fumito, et al.
Publicado: (2015)

Sporadic ALS Astrocytes Induce Neuronal Degeneration In Vivo
por: Qian, Kun, et al.
Publicado: (2017)

Reactive astrocytes in ALS display diminished intron retention
por: Ziff, Oliver J, et al.
Publicado: (2021)

Cobalamin Deficiency: Effect on Homeostasis of Cultured Human Astrocytes
por: Rzepka, Zuzanna, et al.
Publicado: (2019)

Lymphocyte deficiency alters the transcriptomes of oligodendrocytes, but not astrocytes or microglia
por: Krawczyk, Mitchell C., et al.
Publicado: (2023)

Lonchocarpine Increases Nrf2/ARE-Mediated Antioxidant Enzyme Expression by Modulating AMPK and MAPK Signaling in Brain Astrocytes
por: Jeong, Yeon-Hui, et al.
Publicado: (2016)

Dystrophin deficiency leads to dysfunctional glutamate clearance in iPSC derived astrocytes
por: Patel, Abdulsamie M., et al.
Publicado: (2019)

Inhibitors of Oxidative Phosphorylation Modulate Astrocyte Inflammatory Responses through AMPK-Dependent Ptgs2 mRNA Stabilization
por: Astakhova, Alina, et al.
Publicado: (2019)

Astrocytes and Microglia as Non-cell Autonomous Players in the Pathogenesis of ALS
por: Lee, Junghee, et al.
Publicado: (2016)

Rising Stars: Astrocytes as a Therapeutic Target for ALS Disease
por: Izrael, Michal, et al.
Publicado: (2020)

Dysfunction of RNA/RNA-Binding Proteins in ALS Astrocytes and Microglia
por: Rossi, Simona, et al.
Publicado: (2021)

Synaptojanin1 deficiency upregulates basal autophagosome formation in astrocytes
por: Pan, Ping-Yue, et al.
Publicado: (2021)

Presenilin-Deficient Neurons and Astrocytes Display Normal Mitochondrial Phenotypes
por: Contino, Sabrina, et al.
Publicado: (2021)

The Role of Astrocytic Calcium Signaling in the Aged Prefrontal Cortex
por: Guerra-Gomes, Sónia, et al.
Publicado: (2018)

Human astrocytes in the diseased brain
por: Dossi, Elena, et al.
Publicado: (2018)

N-myristoyltransferase deficiency impairs AMPK activation and promotes synovial tissue inflammation
por: Wen, Zhenke, et al.
Publicado: (2019)

Enpp1 deficiency caused chondrocyte apoptosis by inhibiting AMPK signaling pathway
por: Gao, Zhiqiang, et al.
Publicado: (2023)

Reactive astrocytes as neural stem or progenitor cells: In vivo lineage, In vitro potential, and Genome‐wide expression analysis
por: Götz, Magdalena, et al.
Publicado: (2015)

The AMPK/p27(Kip1) Pathway as a Novel Target to Promote Autophagy and Resilience in Aged Cells
por: McKay, Lauren K., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_kg2cd8e82l8f2d3saq89avb6a3