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SAM-Support-Based Electrochemical Sensor for Aβ Biomarker Detection of Alzheimer’s Disease

Alzheimer’s disease has taken the spotlight as a neurodegenerative disease which has caused crucial issues to both society and the economy. Specifically, aging populations in developed countries face an increasingly serious problem due to the increasing budget for patient care and an inadequate labo...

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Autores principales: Le, Phan Gia, Le, Hien T. Ngoc, Kim, Hee-Eun, Cho, Sungbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452698/
https://www.ncbi.nlm.nih.gov/pubmed/37622895
http://dx.doi.org/10.3390/bios13080809
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author Le, Phan Gia
Le, Hien T. Ngoc
Kim, Hee-Eun
Cho, Sungbo
author_facet Le, Phan Gia
Le, Hien T. Ngoc
Kim, Hee-Eun
Cho, Sungbo
author_sort Le, Phan Gia
collection PubMed
description Alzheimer’s disease has taken the spotlight as a neurodegenerative disease which has caused crucial issues to both society and the economy. Specifically, aging populations in developed countries face an increasingly serious problem due to the increasing budget for patient care and an inadequate labor force, and therefore a solution is urgently needed. Recently, diverse techniques for the detection of Alzheimer’s biomarkers have been researched and developed to support early diagnosis and treatment. Among them, electrochemical biosensors and electrode modification proved their effectiveness in the detection of the Aβ biomarker at appropriately low concentrations for practice and point-of-care application. This review discusses the production and detection ability of amyloid beta, an Alzheimer’s biomarker, by electrochemical biosensors with SAM support for antibody conjugation. In addition, future perspectives on SAM for the improvement of electrochemical biosensors are also proposed and discussed.
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spelling pubmed-104526982023-08-26 SAM-Support-Based Electrochemical Sensor for Aβ Biomarker Detection of Alzheimer’s Disease Le, Phan Gia Le, Hien T. Ngoc Kim, Hee-Eun Cho, Sungbo Biosensors (Basel) Review Alzheimer’s disease has taken the spotlight as a neurodegenerative disease which has caused crucial issues to both society and the economy. Specifically, aging populations in developed countries face an increasingly serious problem due to the increasing budget for patient care and an inadequate labor force, and therefore a solution is urgently needed. Recently, diverse techniques for the detection of Alzheimer’s biomarkers have been researched and developed to support early diagnosis and treatment. Among them, electrochemical biosensors and electrode modification proved their effectiveness in the detection of the Aβ biomarker at appropriately low concentrations for practice and point-of-care application. This review discusses the production and detection ability of amyloid beta, an Alzheimer’s biomarker, by electrochemical biosensors with SAM support for antibody conjugation. In addition, future perspectives on SAM for the improvement of electrochemical biosensors are also proposed and discussed. MDPI 2023-08-11 /pmc/articles/PMC10452698/ /pubmed/37622895 http://dx.doi.org/10.3390/bios13080809 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Le, Phan Gia
Le, Hien T. Ngoc
Kim, Hee-Eun
Cho, Sungbo
SAM-Support-Based Electrochemical Sensor for Aβ Biomarker Detection of Alzheimer’s Disease
title SAM-Support-Based Electrochemical Sensor for Aβ Biomarker Detection of Alzheimer’s Disease
title_full SAM-Support-Based Electrochemical Sensor for Aβ Biomarker Detection of Alzheimer’s Disease
title_fullStr SAM-Support-Based Electrochemical Sensor for Aβ Biomarker Detection of Alzheimer’s Disease
title_full_unstemmed SAM-Support-Based Electrochemical Sensor for Aβ Biomarker Detection of Alzheimer’s Disease
title_short SAM-Support-Based Electrochemical Sensor for Aβ Biomarker Detection of Alzheimer’s Disease
title_sort sam-support-based electrochemical sensor for aβ biomarker detection of alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452698/
https://www.ncbi.nlm.nih.gov/pubmed/37622895
http://dx.doi.org/10.3390/bios13080809
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