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The Radical SAM Heme Synthase AhbD from Methanosarcina barkeri Contains Two Auxiliary [4Fe-4S] Clusters

In archaea and sulfate-reducing bacteria, heme is synthesized via the siroheme-dependent pathway. The last step of this route is catalyzed by the Radical SAM enzyme AhbD and consists of the conversion of iron-coproporphyrin III into heme. AhbD belongs to the subfamily of Radical SAM enzymes containi...

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Detalles Bibliográficos
Autores principales: Fix, Isabelle, Heidinger, Lorenz, Friedrich, Thorsten, Layer, Gunhild
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452713/
https://www.ncbi.nlm.nih.gov/pubmed/37627333
http://dx.doi.org/10.3390/biom13081268