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Effects of Repetitive Transcranial Magnetic Stimulation at the Cerebellum on Working Memory

Transcranial magnetic stimulation is a widely used brain intervention technique in clinical settings. In recent years, the role of the cerebellum in learning and memory has become one of the hotspots in the field of cognitive neuroscience. In this study, we recruited 36 healthy college or graduate s...

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Autores principales: Yao, Jiangnan, Song, Bo, Shi, Jingping, Yin, Kuiying, Du, Wentao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452734/
https://www.ncbi.nlm.nih.gov/pubmed/37626514
http://dx.doi.org/10.3390/brainsci13081158
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author Yao, Jiangnan
Song, Bo
Shi, Jingping
Yin, Kuiying
Du, Wentao
author_facet Yao, Jiangnan
Song, Bo
Shi, Jingping
Yin, Kuiying
Du, Wentao
author_sort Yao, Jiangnan
collection PubMed
description Transcranial magnetic stimulation is a widely used brain intervention technique in clinical settings. In recent years, the role of the cerebellum in learning and memory has become one of the hotspots in the field of cognitive neuroscience. In this study, we recruited 36 healthy college or graduate students as subjects and divided them into groups, with 10 to 14 subjects in each group. We performed 5 Hz and 20 Hz repeated transcranial magnetic stimulation and sham stimulation on the Crus II subregion of the cerebellum in different groups, then let them complete the 2-back working memory task before and after the stimulation. We simultaneously recorded the electroencephalogram in the experiment and analyzed the data. We found that after repeated transcranial magnetic stimulation of the cerebellum at 5 Hz and 20 Hz, the N170 and P300 event-related potential components in the prefrontal cortex showed significant differences compared to those in the sham stimulation group. Using phase-locked values to construct brain networks and conduct further analysis, we discovered that stimulation frequencies of 5 Hz and 20 Hz had significant effects on the local and global efficiency of brain networks in comparison to the sham stimulation group. The results showed that repeated transcranial magnetic stimulation on cerebellar targets can effectively affect the subjects’ working memory tasks. Repeated transcranial magnetic stimulation at 5 Hz and 20 Hz could enhance the excitatory responses of the frontal lobes. After stimulation at 5 Hz and 20 Hz, the efficiency of the brain network significantly improved.
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spelling pubmed-104527342023-08-26 Effects of Repetitive Transcranial Magnetic Stimulation at the Cerebellum on Working Memory Yao, Jiangnan Song, Bo Shi, Jingping Yin, Kuiying Du, Wentao Brain Sci Article Transcranial magnetic stimulation is a widely used brain intervention technique in clinical settings. In recent years, the role of the cerebellum in learning and memory has become one of the hotspots in the field of cognitive neuroscience. In this study, we recruited 36 healthy college or graduate students as subjects and divided them into groups, with 10 to 14 subjects in each group. We performed 5 Hz and 20 Hz repeated transcranial magnetic stimulation and sham stimulation on the Crus II subregion of the cerebellum in different groups, then let them complete the 2-back working memory task before and after the stimulation. We simultaneously recorded the electroencephalogram in the experiment and analyzed the data. We found that after repeated transcranial magnetic stimulation of the cerebellum at 5 Hz and 20 Hz, the N170 and P300 event-related potential components in the prefrontal cortex showed significant differences compared to those in the sham stimulation group. Using phase-locked values to construct brain networks and conduct further analysis, we discovered that stimulation frequencies of 5 Hz and 20 Hz had significant effects on the local and global efficiency of brain networks in comparison to the sham stimulation group. The results showed that repeated transcranial magnetic stimulation on cerebellar targets can effectively affect the subjects’ working memory tasks. Repeated transcranial magnetic stimulation at 5 Hz and 20 Hz could enhance the excitatory responses of the frontal lobes. After stimulation at 5 Hz and 20 Hz, the efficiency of the brain network significantly improved. MDPI 2023-08-03 /pmc/articles/PMC10452734/ /pubmed/37626514 http://dx.doi.org/10.3390/brainsci13081158 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yao, Jiangnan
Song, Bo
Shi, Jingping
Yin, Kuiying
Du, Wentao
Effects of Repetitive Transcranial Magnetic Stimulation at the Cerebellum on Working Memory
title Effects of Repetitive Transcranial Magnetic Stimulation at the Cerebellum on Working Memory
title_full Effects of Repetitive Transcranial Magnetic Stimulation at the Cerebellum on Working Memory
title_fullStr Effects of Repetitive Transcranial Magnetic Stimulation at the Cerebellum on Working Memory
title_full_unstemmed Effects of Repetitive Transcranial Magnetic Stimulation at the Cerebellum on Working Memory
title_short Effects of Repetitive Transcranial Magnetic Stimulation at the Cerebellum on Working Memory
title_sort effects of repetitive transcranial magnetic stimulation at the cerebellum on working memory
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452734/
https://www.ncbi.nlm.nih.gov/pubmed/37626514
http://dx.doi.org/10.3390/brainsci13081158
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