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Pre-Operative SARS-CoV-2 Testing in Asymptomatic Heart Transplantation Recipients
Introduction: From the start of the coronavirus disease 2019 (COVID-19) pandemic, international guidelines have recommended pre-operative screening for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) before heart transplantation (HTx). Due to the changing prevalence of COVID-19, the cha...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452735/ https://www.ncbi.nlm.nih.gov/pubmed/37626599 http://dx.doi.org/10.3390/biomedicines11082103 |
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author | Zwetsloot, Peter-Paul Smit, Wouter L. Van der Kaaij, Niels P. Szymanski, Mariusz K. Van der Meer, Manon G. Van Laake, Linda W. Troelstra, Annet Wegdam-Blans, Marjolijn C. A. Oerlemans, Marish I. F. J. |
author_facet | Zwetsloot, Peter-Paul Smit, Wouter L. Van der Kaaij, Niels P. Szymanski, Mariusz K. Van der Meer, Manon G. Van Laake, Linda W. Troelstra, Annet Wegdam-Blans, Marjolijn C. A. Oerlemans, Marish I. F. J. |
author_sort | Zwetsloot, Peter-Paul |
collection | PubMed |
description | Introduction: From the start of the coronavirus disease 2019 (COVID-19) pandemic, international guidelines have recommended pre-operative screening for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) before heart transplantation (HTx). Due to the changing prevalence of COVID-19, the chances of false positive results have increased. Because of increased immunity in the population and evolution of SARS-CoV-2 to current Omicron variants, associated mortality and morbidity have decreased. We set out to investigate the yield and side effects of SARS-CoV-2 screening in our center. Methods: We performed a retrospective cohort study in the University Medical Center Utrecht. The study period was from March 2019 to January 2023. All data from patients who underwent HTx were collected, including all pre-operative and post-operative SARS-CoV-2 tests. Furthermore, all clinical SARS-CoV-2 tests for the indication of potential HTx were screened. Results: In the period under study, 51 patients underwent HTx. None of the recipients reported any symptoms of a viral infection. Fifty HTx recipients were screened for SARS-CoV-2. Forty-nine out of fifty patients tested negative. One patient had a false positive result, potentially delaying the HTx procedure. There were no cancelled HTx procedures due to a true positive SARS-CoV-2 test result. Conclusion: Pre-operative SARS-CoV-2 screening in asymptomatic HTx recipients did not lead to any true positive cases. In 2% of the cases, screening resulted in a false positive test result. With the current Omicron variants, in combination with a low-prevalence situation, we propose to abandon pre-operative SARS-CoV-2 screening and initiate a symptom-driven approach for the general viral testing of patients who are called in for a potential HTx. |
format | Online Article Text |
id | pubmed-10452735 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104527352023-08-26 Pre-Operative SARS-CoV-2 Testing in Asymptomatic Heart Transplantation Recipients Zwetsloot, Peter-Paul Smit, Wouter L. Van der Kaaij, Niels P. Szymanski, Mariusz K. Van der Meer, Manon G. Van Laake, Linda W. Troelstra, Annet Wegdam-Blans, Marjolijn C. A. Oerlemans, Marish I. F. J. Biomedicines Communication Introduction: From the start of the coronavirus disease 2019 (COVID-19) pandemic, international guidelines have recommended pre-operative screening for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) before heart transplantation (HTx). Due to the changing prevalence of COVID-19, the chances of false positive results have increased. Because of increased immunity in the population and evolution of SARS-CoV-2 to current Omicron variants, associated mortality and morbidity have decreased. We set out to investigate the yield and side effects of SARS-CoV-2 screening in our center. Methods: We performed a retrospective cohort study in the University Medical Center Utrecht. The study period was from March 2019 to January 2023. All data from patients who underwent HTx were collected, including all pre-operative and post-operative SARS-CoV-2 tests. Furthermore, all clinical SARS-CoV-2 tests for the indication of potential HTx were screened. Results: In the period under study, 51 patients underwent HTx. None of the recipients reported any symptoms of a viral infection. Fifty HTx recipients were screened for SARS-CoV-2. Forty-nine out of fifty patients tested negative. One patient had a false positive result, potentially delaying the HTx procedure. There were no cancelled HTx procedures due to a true positive SARS-CoV-2 test result. Conclusion: Pre-operative SARS-CoV-2 screening in asymptomatic HTx recipients did not lead to any true positive cases. In 2% of the cases, screening resulted in a false positive test result. With the current Omicron variants, in combination with a low-prevalence situation, we propose to abandon pre-operative SARS-CoV-2 screening and initiate a symptom-driven approach for the general viral testing of patients who are called in for a potential HTx. MDPI 2023-07-26 /pmc/articles/PMC10452735/ /pubmed/37626599 http://dx.doi.org/10.3390/biomedicines11082103 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Zwetsloot, Peter-Paul Smit, Wouter L. Van der Kaaij, Niels P. Szymanski, Mariusz K. Van der Meer, Manon G. Van Laake, Linda W. Troelstra, Annet Wegdam-Blans, Marjolijn C. A. Oerlemans, Marish I. F. J. Pre-Operative SARS-CoV-2 Testing in Asymptomatic Heart Transplantation Recipients |
title | Pre-Operative SARS-CoV-2 Testing in Asymptomatic Heart Transplantation Recipients |
title_full | Pre-Operative SARS-CoV-2 Testing in Asymptomatic Heart Transplantation Recipients |
title_fullStr | Pre-Operative SARS-CoV-2 Testing in Asymptomatic Heart Transplantation Recipients |
title_full_unstemmed | Pre-Operative SARS-CoV-2 Testing in Asymptomatic Heart Transplantation Recipients |
title_short | Pre-Operative SARS-CoV-2 Testing in Asymptomatic Heart Transplantation Recipients |
title_sort | pre-operative sars-cov-2 testing in asymptomatic heart transplantation recipients |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452735/ https://www.ncbi.nlm.nih.gov/pubmed/37626599 http://dx.doi.org/10.3390/biomedicines11082103 |
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