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The Molecular Mechanisms of HLA-G Regulatory Function on Immune Cells during Early Pregnancy

Human leukocyte antigen-G (HLA-G) is a non-classical human major histocompatibility complex (MHC-I) molecule with the membrane-bound and soluble types. HLA-G is primarily expressed by extravillous cytotrophoblast cells located at the maternal–fetal interface during pregnancy and is essential in esta...

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Detalles Bibliográficos
Autores principales: Mao, Jia, Feng, Ying, Zhu, Xiaofeng, Ma, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452754/
https://www.ncbi.nlm.nih.gov/pubmed/37627278
http://dx.doi.org/10.3390/biom13081213
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author Mao, Jia
Feng, Ying
Zhu, Xiaofeng
Ma, Fang
author_facet Mao, Jia
Feng, Ying
Zhu, Xiaofeng
Ma, Fang
author_sort Mao, Jia
collection PubMed
description Human leukocyte antigen-G (HLA-G) is a non-classical human major histocompatibility complex (MHC-I) molecule with the membrane-bound and soluble types. HLA-G is primarily expressed by extravillous cytotrophoblast cells located at the maternal–fetal interface during pregnancy and is essential in establishing immune tolerance. This review provides a comprehensive understanding of the multiple molecular mechanisms by which HLA-G regulates the immune function of NK cells. It highlights that HLA-G binds to microRNA to suppress NK cell cytotoxicity and stimulate the secretion of growth factors to support fetal growth. The interactions between HLA-G and NK cells also activate senescence signaling, promoting spiral artery remodeling and maintaining the balance of maternal–fetal immune responses. In addition, HLA-G can inhibit the function of decidual T cells, dendritic cells, and macrophages. Overall, the interaction between trophoblast cells and immune cells mediated by HLA-G plays a crucial role in understanding immune regulation at the maternal–fetal interface and offers insights into potential treatments for pregnancy-related diseases.
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spelling pubmed-104527542023-08-26 The Molecular Mechanisms of HLA-G Regulatory Function on Immune Cells during Early Pregnancy Mao, Jia Feng, Ying Zhu, Xiaofeng Ma, Fang Biomolecules Review Human leukocyte antigen-G (HLA-G) is a non-classical human major histocompatibility complex (MHC-I) molecule with the membrane-bound and soluble types. HLA-G is primarily expressed by extravillous cytotrophoblast cells located at the maternal–fetal interface during pregnancy and is essential in establishing immune tolerance. This review provides a comprehensive understanding of the multiple molecular mechanisms by which HLA-G regulates the immune function of NK cells. It highlights that HLA-G binds to microRNA to suppress NK cell cytotoxicity and stimulate the secretion of growth factors to support fetal growth. The interactions between HLA-G and NK cells also activate senescence signaling, promoting spiral artery remodeling and maintaining the balance of maternal–fetal immune responses. In addition, HLA-G can inhibit the function of decidual T cells, dendritic cells, and macrophages. Overall, the interaction between trophoblast cells and immune cells mediated by HLA-G plays a crucial role in understanding immune regulation at the maternal–fetal interface and offers insights into potential treatments for pregnancy-related diseases. MDPI 2023-08-03 /pmc/articles/PMC10452754/ /pubmed/37627278 http://dx.doi.org/10.3390/biom13081213 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mao, Jia
Feng, Ying
Zhu, Xiaofeng
Ma, Fang
The Molecular Mechanisms of HLA-G Regulatory Function on Immune Cells during Early Pregnancy
title The Molecular Mechanisms of HLA-G Regulatory Function on Immune Cells during Early Pregnancy
title_full The Molecular Mechanisms of HLA-G Regulatory Function on Immune Cells during Early Pregnancy
title_fullStr The Molecular Mechanisms of HLA-G Regulatory Function on Immune Cells during Early Pregnancy
title_full_unstemmed The Molecular Mechanisms of HLA-G Regulatory Function on Immune Cells during Early Pregnancy
title_short The Molecular Mechanisms of HLA-G Regulatory Function on Immune Cells during Early Pregnancy
title_sort molecular mechanisms of hla-g regulatory function on immune cells during early pregnancy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452754/
https://www.ncbi.nlm.nih.gov/pubmed/37627278
http://dx.doi.org/10.3390/biom13081213
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