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The Molecular Mechanisms of HLA-G Regulatory Function on Immune Cells during Early Pregnancy
Human leukocyte antigen-G (HLA-G) is a non-classical human major histocompatibility complex (MHC-I) molecule with the membrane-bound and soluble types. HLA-G is primarily expressed by extravillous cytotrophoblast cells located at the maternal–fetal interface during pregnancy and is essential in esta...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452754/ https://www.ncbi.nlm.nih.gov/pubmed/37627278 http://dx.doi.org/10.3390/biom13081213 |
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author | Mao, Jia Feng, Ying Zhu, Xiaofeng Ma, Fang |
author_facet | Mao, Jia Feng, Ying Zhu, Xiaofeng Ma, Fang |
author_sort | Mao, Jia |
collection | PubMed |
description | Human leukocyte antigen-G (HLA-G) is a non-classical human major histocompatibility complex (MHC-I) molecule with the membrane-bound and soluble types. HLA-G is primarily expressed by extravillous cytotrophoblast cells located at the maternal–fetal interface during pregnancy and is essential in establishing immune tolerance. This review provides a comprehensive understanding of the multiple molecular mechanisms by which HLA-G regulates the immune function of NK cells. It highlights that HLA-G binds to microRNA to suppress NK cell cytotoxicity and stimulate the secretion of growth factors to support fetal growth. The interactions between HLA-G and NK cells also activate senescence signaling, promoting spiral artery remodeling and maintaining the balance of maternal–fetal immune responses. In addition, HLA-G can inhibit the function of decidual T cells, dendritic cells, and macrophages. Overall, the interaction between trophoblast cells and immune cells mediated by HLA-G plays a crucial role in understanding immune regulation at the maternal–fetal interface and offers insights into potential treatments for pregnancy-related diseases. |
format | Online Article Text |
id | pubmed-10452754 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104527542023-08-26 The Molecular Mechanisms of HLA-G Regulatory Function on Immune Cells during Early Pregnancy Mao, Jia Feng, Ying Zhu, Xiaofeng Ma, Fang Biomolecules Review Human leukocyte antigen-G (HLA-G) is a non-classical human major histocompatibility complex (MHC-I) molecule with the membrane-bound and soluble types. HLA-G is primarily expressed by extravillous cytotrophoblast cells located at the maternal–fetal interface during pregnancy and is essential in establishing immune tolerance. This review provides a comprehensive understanding of the multiple molecular mechanisms by which HLA-G regulates the immune function of NK cells. It highlights that HLA-G binds to microRNA to suppress NK cell cytotoxicity and stimulate the secretion of growth factors to support fetal growth. The interactions between HLA-G and NK cells also activate senescence signaling, promoting spiral artery remodeling and maintaining the balance of maternal–fetal immune responses. In addition, HLA-G can inhibit the function of decidual T cells, dendritic cells, and macrophages. Overall, the interaction between trophoblast cells and immune cells mediated by HLA-G plays a crucial role in understanding immune regulation at the maternal–fetal interface and offers insights into potential treatments for pregnancy-related diseases. MDPI 2023-08-03 /pmc/articles/PMC10452754/ /pubmed/37627278 http://dx.doi.org/10.3390/biom13081213 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mao, Jia Feng, Ying Zhu, Xiaofeng Ma, Fang The Molecular Mechanisms of HLA-G Regulatory Function on Immune Cells during Early Pregnancy |
title | The Molecular Mechanisms of HLA-G Regulatory Function on Immune Cells during Early Pregnancy |
title_full | The Molecular Mechanisms of HLA-G Regulatory Function on Immune Cells during Early Pregnancy |
title_fullStr | The Molecular Mechanisms of HLA-G Regulatory Function on Immune Cells during Early Pregnancy |
title_full_unstemmed | The Molecular Mechanisms of HLA-G Regulatory Function on Immune Cells during Early Pregnancy |
title_short | The Molecular Mechanisms of HLA-G Regulatory Function on Immune Cells during Early Pregnancy |
title_sort | molecular mechanisms of hla-g regulatory function on immune cells during early pregnancy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452754/ https://www.ncbi.nlm.nih.gov/pubmed/37627278 http://dx.doi.org/10.3390/biom13081213 |
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