Cargando…

Advancements in Biosensors Based on the Assembles of Small Organic Molecules and Peptides

Over the past few decades, molecular self-assembly has witnessed tremendous progress in a variety of biosensing and biomedical applications. In particular, self-assembled nanostructures of small organic molecules and peptides with intriguing characteristics (e.g., structure tailoring, facile process...

Descripción completa

Detalles Bibliográficos
Autores principales: Deng, Dehua, Chang, Yong, Liu, Wenjing, Ren, Mingwei, Xia, Ning, Hao, Yuanqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452798/
https://www.ncbi.nlm.nih.gov/pubmed/37622859
http://dx.doi.org/10.3390/bios13080773
_version_ 1785095761162141696
author Deng, Dehua
Chang, Yong
Liu, Wenjing
Ren, Mingwei
Xia, Ning
Hao, Yuanqiang
author_facet Deng, Dehua
Chang, Yong
Liu, Wenjing
Ren, Mingwei
Xia, Ning
Hao, Yuanqiang
author_sort Deng, Dehua
collection PubMed
description Over the past few decades, molecular self-assembly has witnessed tremendous progress in a variety of biosensing and biomedical applications. In particular, self-assembled nanostructures of small organic molecules and peptides with intriguing characteristics (e.g., structure tailoring, facile processability, and excellent biocompatibility) have shown outstanding potential in the development of various biosensors. In this review, we introduced the unique properties of self-assembled nanostructures with small organic molecules and peptides for biosensing applications. We first discussed the applications of such nanostructures in electrochemical biosensors as electrode supports for enzymes and cells and as signal labels with a large number of electroactive units for signal amplification. Secondly, the utilization of fluorescent nanomaterials by self-assembled dyes or peptides was introduced. Thereinto, typical examples based on target-responsive aggregation-induced emission and decomposition-induced fluorescent enhancement were discussed. Finally, the applications of self-assembled nanomaterials in the colorimetric assays were summarized. We also briefly addressed the challenges and future prospects of biosensors based on self-assembled nanostructures.
format Online
Article
Text
id pubmed-10452798
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104527982023-08-26 Advancements in Biosensors Based on the Assembles of Small Organic Molecules and Peptides Deng, Dehua Chang, Yong Liu, Wenjing Ren, Mingwei Xia, Ning Hao, Yuanqiang Biosensors (Basel) Review Over the past few decades, molecular self-assembly has witnessed tremendous progress in a variety of biosensing and biomedical applications. In particular, self-assembled nanostructures of small organic molecules and peptides with intriguing characteristics (e.g., structure tailoring, facile processability, and excellent biocompatibility) have shown outstanding potential in the development of various biosensors. In this review, we introduced the unique properties of self-assembled nanostructures with small organic molecules and peptides for biosensing applications. We first discussed the applications of such nanostructures in electrochemical biosensors as electrode supports for enzymes and cells and as signal labels with a large number of electroactive units for signal amplification. Secondly, the utilization of fluorescent nanomaterials by self-assembled dyes or peptides was introduced. Thereinto, typical examples based on target-responsive aggregation-induced emission and decomposition-induced fluorescent enhancement were discussed. Finally, the applications of self-assembled nanomaterials in the colorimetric assays were summarized. We also briefly addressed the challenges and future prospects of biosensors based on self-assembled nanostructures. MDPI 2023-07-29 /pmc/articles/PMC10452798/ /pubmed/37622859 http://dx.doi.org/10.3390/bios13080773 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Deng, Dehua
Chang, Yong
Liu, Wenjing
Ren, Mingwei
Xia, Ning
Hao, Yuanqiang
Advancements in Biosensors Based on the Assembles of Small Organic Molecules and Peptides
title Advancements in Biosensors Based on the Assembles of Small Organic Molecules and Peptides
title_full Advancements in Biosensors Based on the Assembles of Small Organic Molecules and Peptides
title_fullStr Advancements in Biosensors Based on the Assembles of Small Organic Molecules and Peptides
title_full_unstemmed Advancements in Biosensors Based on the Assembles of Small Organic Molecules and Peptides
title_short Advancements in Biosensors Based on the Assembles of Small Organic Molecules and Peptides
title_sort advancements in biosensors based on the assembles of small organic molecules and peptides
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452798/
https://www.ncbi.nlm.nih.gov/pubmed/37622859
http://dx.doi.org/10.3390/bios13080773
work_keys_str_mv AT dengdehua advancementsinbiosensorsbasedontheassemblesofsmallorganicmoleculesandpeptides
AT changyong advancementsinbiosensorsbasedontheassemblesofsmallorganicmoleculesandpeptides
AT liuwenjing advancementsinbiosensorsbasedontheassemblesofsmallorganicmoleculesandpeptides
AT renmingwei advancementsinbiosensorsbasedontheassemblesofsmallorganicmoleculesandpeptides
AT xianing advancementsinbiosensorsbasedontheassemblesofsmallorganicmoleculesandpeptides
AT haoyuanqiang advancementsinbiosensorsbasedontheassemblesofsmallorganicmoleculesandpeptides