Metabolic Heterogeneity, Plasticity, and Adaptation to “Glutamine Addiction” in Cancer Cells: The Role of Glutaminase and the GTωA [Glutamine Transaminase—ω-Amidase (Glutaminase II)] Pathway

SIMPLE SUMMARY: Many types of cancer cells utilize the common amino acid l-glutamine to maintain their metabolic demands for energy and the nitrogen required for DNA synthesis. Versatility to control energy metabolism from l-glutamine (anaplerosis) is promoted by the use of two distinct pathways. Th...

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Detalles Bibliográficos
Autores principales: Cooper, Arthur J. L., Dorai, Thambi, Pinto, John T., Denton, Travis T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452834/
https://www.ncbi.nlm.nih.gov/pubmed/37627015
http://dx.doi.org/10.3390/biology12081131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452834/
https://www.ncbi.nlm.nih.gov/pubmed/37627015
http://dx.doi.org/10.3390/biology12081131

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