Proteomic Mapping of the Interactome of KRAS Mutants Identifies New Features of RAS Signalling Networks and the Mechanism of Action of Sotorasib

SIMPLE SUMMARY: Cancer is caused by changes in DNA called mutations that alter the way proteins work. We know that RAS proteins are one of the most commonly mutated proteins in cancer cells. These proteins work like a light switch and mutant RAS remain in the ON position sending signals to the cell...

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Detalles Bibliográficos
Autores principales: Nolan, Aoife, Raso, Cinzia, Kolch, Walter, von Kriegsheim, Alex, Wynne, Kieran, Matallanas, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452836/
https://www.ncbi.nlm.nih.gov/pubmed/37627169
http://dx.doi.org/10.3390/cancers15164141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452836/
https://www.ncbi.nlm.nih.gov/pubmed/37627169
http://dx.doi.org/10.3390/cancers15164141

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