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Proteomic Mapping of the Interactome of KRAS Mutants Identifies New Features of RAS Signalling Networks and the Mechanism of Action of Sotorasib
SIMPLE SUMMARY: Cancer is caused by changes in DNA called mutations that alter the way proteins work. We know that RAS proteins are one of the most commonly mutated proteins in cancer cells. These proteins work like a light switch and mutant RAS remain in the ON position sending signals to the cell...
Autores principales: | Nolan, Aoife, Raso, Cinzia, Kolch, Walter, von Kriegsheim, Alex, Wynne, Kieran, Matallanas, David |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452836/ https://www.ncbi.nlm.nih.gov/pubmed/37627169 http://dx.doi.org/10.3390/cancers15164141 |
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