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Recent Advances in the Production of Pharmaceuticals Using Selective Laser Sintering

Selective laser sintering (SLS) is an additive manufacturing process that has shown promise in the production of medical devices, including hip cups, knee trays, dental crowns, and hearing aids. SLS-based 3D-printed dosage forms have the potential to revolutionise the production of personalised drug...

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Autores principales: Balasankar, Athinarayanan, Anbazhakan, Kandasamy, Arul, Velusamy, Mutharaian, Velankadu Natrayan, Sriram, Ganesan, Aruchamy, Kanakaraj, Oh, Tae Hwan, Ramasundaram, Subramaniyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452903/
https://www.ncbi.nlm.nih.gov/pubmed/37622935
http://dx.doi.org/10.3390/biomimetics8040330
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author Balasankar, Athinarayanan
Anbazhakan, Kandasamy
Arul, Velusamy
Mutharaian, Velankadu Natrayan
Sriram, Ganesan
Aruchamy, Kanakaraj
Oh, Tae Hwan
Ramasundaram, Subramaniyan
author_facet Balasankar, Athinarayanan
Anbazhakan, Kandasamy
Arul, Velusamy
Mutharaian, Velankadu Natrayan
Sriram, Ganesan
Aruchamy, Kanakaraj
Oh, Tae Hwan
Ramasundaram, Subramaniyan
author_sort Balasankar, Athinarayanan
collection PubMed
description Selective laser sintering (SLS) is an additive manufacturing process that has shown promise in the production of medical devices, including hip cups, knee trays, dental crowns, and hearing aids. SLS-based 3D-printed dosage forms have the potential to revolutionise the production of personalised drugs. The ability to manipulate the porosity of printed materials is a particularly exciting aspect of SLS. Porous tablet formulations produced by SLS can disintegrate orally within seconds, which is challenging to achieve with traditional methods. SLS also enables the creation of amorphous solid dispersions in a single step, rather than the multi-step process required with conventional methods. This review provides an overview of 3D printing, describes the operating mechanism and necessary materials for SLS, and highlights recent advances in SLS for biomedical and pharmaceutical applications. Furthermore, an in-depth comparison and contrast of various 3D printing technologies for their effectiveness in tissue engineering applications is also presented in this review.
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spelling pubmed-104529032023-08-26 Recent Advances in the Production of Pharmaceuticals Using Selective Laser Sintering Balasankar, Athinarayanan Anbazhakan, Kandasamy Arul, Velusamy Mutharaian, Velankadu Natrayan Sriram, Ganesan Aruchamy, Kanakaraj Oh, Tae Hwan Ramasundaram, Subramaniyan Biomimetics (Basel) Review Selective laser sintering (SLS) is an additive manufacturing process that has shown promise in the production of medical devices, including hip cups, knee trays, dental crowns, and hearing aids. SLS-based 3D-printed dosage forms have the potential to revolutionise the production of personalised drugs. The ability to manipulate the porosity of printed materials is a particularly exciting aspect of SLS. Porous tablet formulations produced by SLS can disintegrate orally within seconds, which is challenging to achieve with traditional methods. SLS also enables the creation of amorphous solid dispersions in a single step, rather than the multi-step process required with conventional methods. This review provides an overview of 3D printing, describes the operating mechanism and necessary materials for SLS, and highlights recent advances in SLS for biomedical and pharmaceutical applications. Furthermore, an in-depth comparison and contrast of various 3D printing technologies for their effectiveness in tissue engineering applications is also presented in this review. MDPI 2023-07-27 /pmc/articles/PMC10452903/ /pubmed/37622935 http://dx.doi.org/10.3390/biomimetics8040330 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Balasankar, Athinarayanan
Anbazhakan, Kandasamy
Arul, Velusamy
Mutharaian, Velankadu Natrayan
Sriram, Ganesan
Aruchamy, Kanakaraj
Oh, Tae Hwan
Ramasundaram, Subramaniyan
Recent Advances in the Production of Pharmaceuticals Using Selective Laser Sintering
title Recent Advances in the Production of Pharmaceuticals Using Selective Laser Sintering
title_full Recent Advances in the Production of Pharmaceuticals Using Selective Laser Sintering
title_fullStr Recent Advances in the Production of Pharmaceuticals Using Selective Laser Sintering
title_full_unstemmed Recent Advances in the Production of Pharmaceuticals Using Selective Laser Sintering
title_short Recent Advances in the Production of Pharmaceuticals Using Selective Laser Sintering
title_sort recent advances in the production of pharmaceuticals using selective laser sintering
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452903/
https://www.ncbi.nlm.nih.gov/pubmed/37622935
http://dx.doi.org/10.3390/biomimetics8040330
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