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Multicellular Complex Tumor Spheroid Response to DNA Repair Inhibitors in Combination with DNA-damaging Drugs

Multicellular spheroids comprised of malignant cells, endothelial cells, and mesenchymal stem cells served as an in vitro model of human solid tumors to investigate the potentiation of DNA-damaging drugs by pharmacologic modulation of DNA repair pathways. The DNA-damaging drugs, topotecan, trabected...

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Detalles Bibliográficos
Autores principales:	Dexheimer, Thomas S., Coussens, Nathan P., Silvers, Thomas, Wright, John, Morris, Joel, Doroshow, James H., Teicher, Beverly A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452929/ https://www.ncbi.nlm.nih.gov/pubmed/37637936 http://dx.doi.org/10.1158/2767-9764.CRC-23-0193

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