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From Molecules to Imaging: Assessment of Placental Hypoxia Biomarkers in Placental Insufficiency Syndromes

Placental hypoxia poses significant risks to both the developing fetus and the mother during pregnancy, underscoring the importance of early detection and monitoring. Effectively identifying placental hypoxia and evaluating the deterioration in placental function requires reliable biomarkers. Molecu...

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Autores principales: Al Darwish, Fatimah M., Meijerink, Lotte, Coolen, Bram F., Strijkers, Gustav J., Bekker, Mireille, Lely, Titia, Terstappen, Fieke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452979/
https://www.ncbi.nlm.nih.gov/pubmed/37626890
http://dx.doi.org/10.3390/cells12162080
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author Al Darwish, Fatimah M.
Meijerink, Lotte
Coolen, Bram F.
Strijkers, Gustav J.
Bekker, Mireille
Lely, Titia
Terstappen, Fieke
author_facet Al Darwish, Fatimah M.
Meijerink, Lotte
Coolen, Bram F.
Strijkers, Gustav J.
Bekker, Mireille
Lely, Titia
Terstappen, Fieke
author_sort Al Darwish, Fatimah M.
collection PubMed
description Placental hypoxia poses significant risks to both the developing fetus and the mother during pregnancy, underscoring the importance of early detection and monitoring. Effectively identifying placental hypoxia and evaluating the deterioration in placental function requires reliable biomarkers. Molecular biomarkers in placental tissue can only be determined post-delivery and while maternal blood biomarkers can be measured over time, they can merely serve as proxies for placental function. Therefore, there is an increasing demand for non-invasive imaging techniques capable of directly assessing the placental condition over time. Recent advancements in imaging technologies, including photoacoustic and magnetic resonance imaging, offer promising tools for detecting and monitoring placental hypoxia. Integrating molecular and imaging biomarkers may revolutionize the detection and monitoring of placental hypoxia, improving pregnancy outcomes and reducing long-term health complications. This review describes current research on molecular and imaging biomarkers of placental hypoxia both in human and animal studies and aims to explore the benefits of an integrated approach throughout gestation.
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spelling pubmed-104529792023-08-26 From Molecules to Imaging: Assessment of Placental Hypoxia Biomarkers in Placental Insufficiency Syndromes Al Darwish, Fatimah M. Meijerink, Lotte Coolen, Bram F. Strijkers, Gustav J. Bekker, Mireille Lely, Titia Terstappen, Fieke Cells Review Placental hypoxia poses significant risks to both the developing fetus and the mother during pregnancy, underscoring the importance of early detection and monitoring. Effectively identifying placental hypoxia and evaluating the deterioration in placental function requires reliable biomarkers. Molecular biomarkers in placental tissue can only be determined post-delivery and while maternal blood biomarkers can be measured over time, they can merely serve as proxies for placental function. Therefore, there is an increasing demand for non-invasive imaging techniques capable of directly assessing the placental condition over time. Recent advancements in imaging technologies, including photoacoustic and magnetic resonance imaging, offer promising tools for detecting and monitoring placental hypoxia. Integrating molecular and imaging biomarkers may revolutionize the detection and monitoring of placental hypoxia, improving pregnancy outcomes and reducing long-term health complications. This review describes current research on molecular and imaging biomarkers of placental hypoxia both in human and animal studies and aims to explore the benefits of an integrated approach throughout gestation. MDPI 2023-08-17 /pmc/articles/PMC10452979/ /pubmed/37626890 http://dx.doi.org/10.3390/cells12162080 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Al Darwish, Fatimah M.
Meijerink, Lotte
Coolen, Bram F.
Strijkers, Gustav J.
Bekker, Mireille
Lely, Titia
Terstappen, Fieke
From Molecules to Imaging: Assessment of Placental Hypoxia Biomarkers in Placental Insufficiency Syndromes
title From Molecules to Imaging: Assessment of Placental Hypoxia Biomarkers in Placental Insufficiency Syndromes
title_full From Molecules to Imaging: Assessment of Placental Hypoxia Biomarkers in Placental Insufficiency Syndromes
title_fullStr From Molecules to Imaging: Assessment of Placental Hypoxia Biomarkers in Placental Insufficiency Syndromes
title_full_unstemmed From Molecules to Imaging: Assessment of Placental Hypoxia Biomarkers in Placental Insufficiency Syndromes
title_short From Molecules to Imaging: Assessment of Placental Hypoxia Biomarkers in Placental Insufficiency Syndromes
title_sort from molecules to imaging: assessment of placental hypoxia biomarkers in placental insufficiency syndromes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452979/
https://www.ncbi.nlm.nih.gov/pubmed/37626890
http://dx.doi.org/10.3390/cells12162080
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