Cargando…

Vat Photopolymerization 3D Printing of Hydrogels with Re-Adjustable Swelling

Vat photopolymerization typically prints highly crosslinked networks. Printing hydrogels, which are also networks but with a high swelling capacity in water and therefore with low crosslinking density, is a challenge for this technique. However, it may be of interest in medicine and in other areas,...

Descripción completa

Detalles Bibliográficos
Autores principales: Liz-Basteiro, Pedro, Reviriego, Felipe, Martínez-Campos, Enrique, Reinecke, Helmut, Elvira, Carlos, Rodríguez-Hernández, Juan, Gallardo, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452991/
https://www.ncbi.nlm.nih.gov/pubmed/37623055
http://dx.doi.org/10.3390/gels9080600
_version_ 1785095809452212224
author Liz-Basteiro, Pedro
Reviriego, Felipe
Martínez-Campos, Enrique
Reinecke, Helmut
Elvira, Carlos
Rodríguez-Hernández, Juan
Gallardo, Alberto
author_facet Liz-Basteiro, Pedro
Reviriego, Felipe
Martínez-Campos, Enrique
Reinecke, Helmut
Elvira, Carlos
Rodríguez-Hernández, Juan
Gallardo, Alberto
author_sort Liz-Basteiro, Pedro
collection PubMed
description Vat photopolymerization typically prints highly crosslinked networks. Printing hydrogels, which are also networks but with a high swelling capacity in water and therefore with low crosslinking density, is a challenge for this technique. However, it may be of interest in medicine and in other areas, since it would allow for the preparation of this type of 3D-shaped material. In this work, an approach for printing hydrogels via vat photopolymerization that uses a mixture of stable and hydrolysable crosslinkers has been evaluated so that an initial highly crosslinked network can be printed, although after hydrolysis it becomes a network with low crosslinking. This approach has been studied with PEO/PEG-related formulations, that is, with a PEG-dimethacrylate as a stable crosslinker, a PEO-related derivative carrying β-aminoesters as a degradable crosslinker, and PEG-methyl ether acrylate and hydroxyethyl acrylate as monofunctional monomers. A wide family of formulations has been studied, maintaining the weight percentage of the crosslinkers at 15%. Resins have been studied in terms of viscosity, and the printing process has been evaluated through the generation of Jacobs working curves. It has been shown that this approach allows for the printing of pieces of different shapes and sizes via vat photopolymerization, and that these pieces can re-ajust their water content in a tailored fashion through treatments in different media (PBS or pH 10 buffer).
format Online
Article
Text
id pubmed-10452991
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104529912023-08-26 Vat Photopolymerization 3D Printing of Hydrogels with Re-Adjustable Swelling Liz-Basteiro, Pedro Reviriego, Felipe Martínez-Campos, Enrique Reinecke, Helmut Elvira, Carlos Rodríguez-Hernández, Juan Gallardo, Alberto Gels Article Vat photopolymerization typically prints highly crosslinked networks. Printing hydrogels, which are also networks but with a high swelling capacity in water and therefore with low crosslinking density, is a challenge for this technique. However, it may be of interest in medicine and in other areas, since it would allow for the preparation of this type of 3D-shaped material. In this work, an approach for printing hydrogels via vat photopolymerization that uses a mixture of stable and hydrolysable crosslinkers has been evaluated so that an initial highly crosslinked network can be printed, although after hydrolysis it becomes a network with low crosslinking. This approach has been studied with PEO/PEG-related formulations, that is, with a PEG-dimethacrylate as a stable crosslinker, a PEO-related derivative carrying β-aminoesters as a degradable crosslinker, and PEG-methyl ether acrylate and hydroxyethyl acrylate as monofunctional monomers. A wide family of formulations has been studied, maintaining the weight percentage of the crosslinkers at 15%. Resins have been studied in terms of viscosity, and the printing process has been evaluated through the generation of Jacobs working curves. It has been shown that this approach allows for the printing of pieces of different shapes and sizes via vat photopolymerization, and that these pieces can re-ajust their water content in a tailored fashion through treatments in different media (PBS or pH 10 buffer). MDPI 2023-07-25 /pmc/articles/PMC10452991/ /pubmed/37623055 http://dx.doi.org/10.3390/gels9080600 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liz-Basteiro, Pedro
Reviriego, Felipe
Martínez-Campos, Enrique
Reinecke, Helmut
Elvira, Carlos
Rodríguez-Hernández, Juan
Gallardo, Alberto
Vat Photopolymerization 3D Printing of Hydrogels with Re-Adjustable Swelling
title Vat Photopolymerization 3D Printing of Hydrogels with Re-Adjustable Swelling
title_full Vat Photopolymerization 3D Printing of Hydrogels with Re-Adjustable Swelling
title_fullStr Vat Photopolymerization 3D Printing of Hydrogels with Re-Adjustable Swelling
title_full_unstemmed Vat Photopolymerization 3D Printing of Hydrogels with Re-Adjustable Swelling
title_short Vat Photopolymerization 3D Printing of Hydrogels with Re-Adjustable Swelling
title_sort vat photopolymerization 3d printing of hydrogels with re-adjustable swelling
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452991/
https://www.ncbi.nlm.nih.gov/pubmed/37623055
http://dx.doi.org/10.3390/gels9080600
work_keys_str_mv AT lizbasteiropedro vatphotopolymerization3dprintingofhydrogelswithreadjustableswelling
AT reviriegofelipe vatphotopolymerization3dprintingofhydrogelswithreadjustableswelling
AT martinezcamposenrique vatphotopolymerization3dprintingofhydrogelswithreadjustableswelling
AT reineckehelmut vatphotopolymerization3dprintingofhydrogelswithreadjustableswelling
AT elviracarlos vatphotopolymerization3dprintingofhydrogelswithreadjustableswelling
AT rodriguezhernandezjuan vatphotopolymerization3dprintingofhydrogelswithreadjustableswelling
AT gallardoalberto vatphotopolymerization3dprintingofhydrogelswithreadjustableswelling