Relevance of ATM Status in Driving Sensitivity to DNA Damage Response Inhibitors in Patient-Derived Xenograft Models

SIMPLE SUMMARY: The inactivation of DNA damage response (DDR) pathways provides new opportunities to target cancers. One of the key DDR kinases is ATM which is reported to be mutated across a wide range of solid and haematological cancers. There is contrasting evidence on how ATM alterations in pati...

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Detalles Bibliográficos
Autores principales: Karmokar, Ankur, Sargeant, Rebecca, Hughes, Adina M., Baakza, Hana, Wilson, Zena, Talbot, Sara, Bloomfield, Sarah, Leo, Elisabetta, Jones, Gemma N., Likhatcheva, Maria, Tobalina, Luis, Dean, Emma, Cadogan, Elaine B., Lau, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453052/
https://www.ncbi.nlm.nih.gov/pubmed/37627223
http://dx.doi.org/10.3390/cancers15164195

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