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NTCP Calculations of Five Different Irradiation Techniques for the Treatment of Thymoma

This study provided normal tissue complication probability (NTCP) calculations from photon radiotherapy techniques in eleven patients with thymoma. Five plans were created for each participant using three-dimensional conformal radiotherapy (3D-CRT), five-field intensity modulated radiotherapy (5F-IM...

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Autores principales: Mazonakis, Michalis, Kachris, Stefanos, Tolia, Maria, Damilakis, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453123/
https://www.ncbi.nlm.nih.gov/pubmed/37623042
http://dx.doi.org/10.3390/curroncol30080561
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author Mazonakis, Michalis
Kachris, Stefanos
Tolia, Maria
Damilakis, John
author_facet Mazonakis, Michalis
Kachris, Stefanos
Tolia, Maria
Damilakis, John
author_sort Mazonakis, Michalis
collection PubMed
description This study provided normal tissue complication probability (NTCP) calculations from photon radiotherapy techniques in eleven patients with thymoma. Five plans were created for each participant using three-dimensional conformal radiotherapy (3D-CRT), five-field intensity modulated radiotherapy (5F-IMRT), seven-field IMRT (7F-IMRT), and volumetric modulated arc therapy with full arcs (FA-VMAT) and partial arcs (PA-VMAT). The target coverage, homogeneity index and conformation number for the planning target volume (PTV) and dosimetric parameters for the organs-at-risk (OARs) were taken from the fifty-five generated plans. The patient-specific NTCP of the lungs, heart and esophagus was calculated with an in-house software tool using differential dose-volume histograms and the equivalent uniform dose model. The PTV dose metrics from 3D-CRT were inferior to those from IMRT and VMAT plans. The dose constraints for the OARs were met in all treatment plans. The NTCP range of the lungs, heart and esophagus was 0.34–0.49%, 0.03–0.06% and 0.08–0.10%, respectively. The NTCPs of the heart for the incidence of peridarditis from IMRT and VMAT were significantly smaller than those from conformal treatment (p < 0.05). The 7F-IMRT was significantly superior to FA-VMAT in reducing the NTCP of the lungs and the risk of pneumonitis (p = 0.001). Similar superiority of 5F-IMRT over PA-VMAT for lung protection was found (p = 0.009). The presented results may be employed in the selection of the appropriate irradiation technique for restricting the complications in the adjacent OARs.
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spelling pubmed-104531232023-08-26 NTCP Calculations of Five Different Irradiation Techniques for the Treatment of Thymoma Mazonakis, Michalis Kachris, Stefanos Tolia, Maria Damilakis, John Curr Oncol Article This study provided normal tissue complication probability (NTCP) calculations from photon radiotherapy techniques in eleven patients with thymoma. Five plans were created for each participant using three-dimensional conformal radiotherapy (3D-CRT), five-field intensity modulated radiotherapy (5F-IMRT), seven-field IMRT (7F-IMRT), and volumetric modulated arc therapy with full arcs (FA-VMAT) and partial arcs (PA-VMAT). The target coverage, homogeneity index and conformation number for the planning target volume (PTV) and dosimetric parameters for the organs-at-risk (OARs) were taken from the fifty-five generated plans. The patient-specific NTCP of the lungs, heart and esophagus was calculated with an in-house software tool using differential dose-volume histograms and the equivalent uniform dose model. The PTV dose metrics from 3D-CRT were inferior to those from IMRT and VMAT plans. The dose constraints for the OARs were met in all treatment plans. The NTCP range of the lungs, heart and esophagus was 0.34–0.49%, 0.03–0.06% and 0.08–0.10%, respectively. The NTCPs of the heart for the incidence of peridarditis from IMRT and VMAT were significantly smaller than those from conformal treatment (p < 0.05). The 7F-IMRT was significantly superior to FA-VMAT in reducing the NTCP of the lungs and the risk of pneumonitis (p = 0.001). Similar superiority of 5F-IMRT over PA-VMAT for lung protection was found (p = 0.009). The presented results may be employed in the selection of the appropriate irradiation technique for restricting the complications in the adjacent OARs. MDPI 2023-08-19 /pmc/articles/PMC10453123/ /pubmed/37623042 http://dx.doi.org/10.3390/curroncol30080561 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mazonakis, Michalis
Kachris, Stefanos
Tolia, Maria
Damilakis, John
NTCP Calculations of Five Different Irradiation Techniques for the Treatment of Thymoma
title NTCP Calculations of Five Different Irradiation Techniques for the Treatment of Thymoma
title_full NTCP Calculations of Five Different Irradiation Techniques for the Treatment of Thymoma
title_fullStr NTCP Calculations of Five Different Irradiation Techniques for the Treatment of Thymoma
title_full_unstemmed NTCP Calculations of Five Different Irradiation Techniques for the Treatment of Thymoma
title_short NTCP Calculations of Five Different Irradiation Techniques for the Treatment of Thymoma
title_sort ntcp calculations of five different irradiation techniques for the treatment of thymoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453123/
https://www.ncbi.nlm.nih.gov/pubmed/37623042
http://dx.doi.org/10.3390/curroncol30080561
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